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Search results for: ALZHEIMER'S DISEASE.
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An Overview of Several Inhibitors for Alzheimer’s Disease: Characterization and Failure
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Oxidative stress and oxidative DNA damage is characteristic for mixed Alzheimer disease/vascular dementia
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Are advanced glycation end-products specific biomarkers for Alzheimer's disease?
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Vitamin D receptor gene polymorphisms in Alzheimer's disease patients
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Cognitive Abilities of Alzheimers Disease Transgenic Mice are Modulated by Social Context and Circadian Rhythm
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Analysis of Serum of Patients With Alzheimer’s Disease for the Level of Advanced Glycation End Products
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Investigating the disease‐modifying properties of sclerotiorin in Alzheimer's therapy using acetylcholinesterase inhibition
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SYNTHESIS OF PHOSPHORUS TACRINE ANALOGUES AS A NEW POTENTIAL ANTI-ALZHEIMER’S DISEASE AGENTS
PublicationA series of novel phosphorus tacrine derivatives was obtained in three steps, including synthesis of 9-chlorotacrine, connection of 9-chlorotacrine with hexamethylenediamine, 1,8-diaminooctane and 1,12-diaminododecane linkers and reaction of obtained tacrine diamine analogues with corresponding acid ester to give nine tacrine organophosphorus compounds. All of the obtained final structures were characterized by 1H NMR, 13C NMR,...
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Investigating the disease- modifying properties of sclerotiorin in Alzheimer's therapy using acetylcholinesterase inhibition
PublicationAlzheimer's disease (AD) is a progressive neurodegenerative disorder caused due to the damage and loss of neurons in specific brain regions. It is the most common form of dementia observed in older people. The symptoms start with memory loss and gradually cause the inability to speak and do day-to-day activities. The cost of caring for those affected individuals is huge and is probably beyond most developing countries capability....
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Tackling Alzheimer's disease: Hypothetical synergism between anti-inflammatory and anti-diabetic agents
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Ovocystatin Induced Changes in Expression of Alzheimer’s Disease Relevant Proteins in APP/PS1 Transgenic Mice
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Errorless Learning as a method of neuropsychological rehabilitation of individuals suffering from dementia in the course of Alzheimer’s disease
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Detection of Alzheimer's disease using Otsu thresholding with tunicate swarm algorithm and deep belief network
PublicationIntroduction: Alzheimer’s Disease (AD) is a degenerative brain disorder characterized by cognitive and memory dysfunctions. The early detection of AD is necessary to reduce the mortality rate through slowing down its progression. The prevention and detection of AD is the emerging research topic for many researchers. The structural Magnetic Resonance Imaging (sMRI) is an extensively used imaging technique in detection of AD, because...
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Selected mice models based on APP, MAPT and presenilin gene mutations in research on the pathogenesis of Alzheimer’s disease
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Design of new cholinesterase inhibitors based on phosphorus analogs of tacrine as potential anti-Alzheimer’s disease agents
PublicationBased on the analysis of the determined free binding energy (using the AutoDock Vina 1.1.2 docking program), the most potent cholinesterase inhibitors were selected. Moreover, studies of 3D visualization of the results of molecular modeling led to the identification of potential sites for the interaction of new potential inhibitors with amino acid residues building active sites of investigated cholinesterases.
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Design, synthesis and biological evaluation of novel N-phosphorylated and O-phosphorylated tacrine derivatives as potential drugs against Alzheimer’s disease
PublicationIn this work, we designed, synthesised and biologically investigated a novel series of 14N- and O-phosphorylated tacrine derivatives as potential anti-Alzheimer’s disease agents. In the reaction of 9-chlorotacrine and corresponding diamines/aminoalkylalcohol we obtained diamino and aminoalkylhydroxy tacrine derivatives. Next, the compounds were acid to give final products 6–13 and 16–21 that were characterised by 1H, 13 C, 31P...
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Gastroesophageal Reflux Disease in Children with Interstitial Lung Disease
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Therapeutic Potential of Multifunctional Tacrine Analogues
PublicationTacrine is a potent inhibitor of cholinesterases (acetylcholinesterase and butyrylcholinesterase) that shows limiting clinical application by liver toxicity. In spite of this, analogues of tacrine are considered as a model inhibitor of cholinesterases in the therapy of Alzheimer’s disease. The interest in these compounds is mainly related to a high variety of their structure and biological properties. In the present review, we...
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cGMP level in idiopathic Parkinson’s disease patients with and without cardiovascular disease – A pilot study
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Diverse Expression of Selected SMN Complex Proteins in Humans with Sporadic Amyotrophic Lateral Sclerosis and in a Transgenic Rat Model of Familial Form of the Disease
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Depression and anxiety in cardiovascular disease
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Sleep disorders in Parkinson's disease
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Kikuchi-Fujimoto disease: State of the art
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Oxylipins in Plant Protection/Disease Management
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Markov Model of Disease Development and Recovery
PublicationMarkov models are commonly used to simulate diseases and allow modeling of multiple health states and outcomes. Starting with the well known Le Bras multistate model (cascading failure model) with time-independent transitions we will see how simple Markov mortality models may be pressed into the service of survival and event history analysis. We will focus on more complex models which will be able to take into account remission,...
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Genetic predisposition to inflammatory bowel disease
PublicationInflammatory bowel disease (IBD) is a chronic, incurable inflammatory disease of the digestive system. The two main disease entities included in the IBD are ulcerative colitis and Crohn's disease. According to epidemiological studies there are more and more new cases every year. In especially among the youngest patients with symptoms of malnutrition and growth inhibition to land up in hospitalwith cancer suspected. The purpose...
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Three episodes of Kawasaki disease including one after the Pneumo 23 vaccine in a child with a family history of Kawasaki disease
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Metabolomics in cardiovascular diseases
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Treatment of Autoinflammatory Diseases
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Vaccinations in rheumatic diseases
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Behçet’s Disease in a Polish Patient: A Case Report
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Diagnosis of preeclampsia in women with diabetic kidney disease
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Pertussis: History of the Disease and Current Prevention Failure
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Editorial(Hot Topic: Proteolysis in Health and Disease)
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Gastroesophageal Reflux Disease in Children with Cystic Fibrosis
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Arsenic causing gallbladder cancer disease in Bihar
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Different effect of smoking on genders in Crohn’s disease
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Antibody Cross-Reactivity in Serodiagnosis of Lyme Disease
PublicationLyme disease is a tick-borne disease caused by spirochetes belonging to the Borrelia burgdorferi sensu lato complex. The disease is characterized by a varied course; therefore, the basis for diagnosis is laboratory methods. Currently, a two-tiered serological test is recommended, using an ELISA as a screening test and a Western blot as a confirmatory test. This approach was introduced due to the relatively high number of false-positive...
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Chlorido(4-morpholinecarbodithioato-k2S,S')(triphenylphosphine)nickel(II)
PublicationPrzeprowadzono syntezę oraz wyznaczono strukturę związku [Ni(C5H8NOS2)Cl(C18H15P)]. Tytułowy kompleks chloro(morfolinoditiokarbaminiano-S,S')(trifenylofosfina)-nikiel(II) posiada nieznacznie zniekształcony płaski kwadratowy rdzeń NiClS2P.
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Chlorido(ethyldiphenylphosphine-P)(1-pyrrolidinecarbodithioato-S,S)nickel(II)
PublicationPrzedmiotem publikacji jest struktura krystaliczna tytułowego [NiCl{S2CN(CH2)4}Cl(C14H15P)]. Atom niklu jest w tym przypadku skoordynowany przez S,S-chelatującą resztę ditiokarbaminianową, cząsteczkę fosfiny, zaś geometrię koordynacyjną dopełnia atom chloru.
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Tris(1-pyrrolidinylcarbodithioato-S,S')-cobalt(III) chloroform disolvate
PublicationTytułowy kompleks tris(1-pirolidynoditiokarbaminiano-S,S')-kobalt(III), będący disolwatem chloroformu zawiera Co(III) oktaedrycznie skoordynowany przez trzy reszty ditiokarbaminowe. Molekuły chloroformu zaangażowane są w tworzenie cząsteczkami kompleksu oddziaływań typu C-H...S
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Wpływ wraków na środowisko na przykładzie s/s ''Stuttgart''
PublicationGłównym celem pracy doktorskiej była próba określenia charakteru i wielkości oddziaływania na środowisko zatopionego podczas II wojny światowej wraku statku s/s Stuttgart. W celu określenia stopnia zagrożenia dla środowiska wykonano analizy chemiczne i badania ekotoksykologiczne próbek wody morskiej, osadów powierzchniowych i rdzeni. Odpowiednio przygotowane próbki wody morskiej i osadów poddane zostały analizom w celu oznaczenia...
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Developing the s factor
PublicationWzory IMO na mnożnik s (p-wo przetrwania statku z zatopionym przedziałem) abstrahują od czasu przetrwania, jak i falowania. Pokazano związek 'pierwotnego' mnożnika s z czasem przetwania na danym falowaniu oraz pokazano w jaki sposób przetransformować mnożnik s odpowiadający półgodzinnym doświadczeniom przewracania statku na mnożnik odpowiadający dłuższym przebiegom doświadczeń. Wydłużenie czasu doświadczeń nie ma drastycznego wpływu....
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The Impact of Huntington Disease on Family Carers: a Literature Overview
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Tackling age-related disease: time for a step forward
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Pet Ownership and the Risk of Arterial Hypertension and Cardiovascular Disease
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The Global Burden of Disease Study 2015 and Blood Pressure
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Managing comorbid cardiovascular disease and sleep apnea with pharmacotherapy
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EDITORIALHypertension and cardiovascular disease: Is arterial stiffness the heart of the matter?
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Plasma Lipid Composition and Risk of Developing Cardiovascular Disease
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