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Search results for: TRICHOBLASTIC TUMOUR
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Significance of Dermoscopy in Association with Clinical Features in Differentiation of Basal Cell Carcinoma and Benign Trichoblastic Tumours
PublicationBackground: Although basal cell carcinoma (BCC) can, in the majority of cases, be diagnosed based on clinical and dermoscopic assessment, a potential overlap with benign adnexal skin tumours seems to exist, including trichoblastic tumours (TT). Methods: Retrospective analysis of clinical and dermoscopic features of benign TT and BCC cases was performed to develop a diagnostic algorithm with a potential utility in clinical practice....
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Wilms’ tumour-the reality of tissue analysis in the Polish Paediatric Solid Tumours Group
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Identification of High-Risk Stage II Colorectal Tumors by Combined Analysis of the NDRG1 Gene Expression and the Depth of Tumor Invasion
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Complete tumour regressions induced by vaccination with IL-12 gene-transduced tumour cells in combination with IL-15 in a melanoma model in mice
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Folliculotropic mycosis fungoides coexisting with pancreatic neuroendocrine tumour
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Deep convolutional neural network for predicting kidney tumour malignancy
PublicationPurpose: According to the statistics, up to 15-20% of removed solid kidney tumors turn out to be benign in postoperative histopathological examination, despite having been identified as malignant by a radiologist. The aim of the research was to limit the number of unnecessary nephrectomies of benign tumors. Methods or Background: We propose a machine-aided diagnostic system for kidney...
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Regarding the “Tumour spillage of the pleomorphic adenoma of the parotid gland: A proposal for intraoperative measures”
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A Robust Method for Sample Preparation of Gastrointestinal Stromal Tumour for LC/MS Untargeted Metabolomics
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The significance of VEGF-C/VEGFR-2 interaction in the neovascularization and prognosis of nephroblastoma (Wilms' tumour)
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The potential anti-tumor activity of neoteric solvents
PublicationCiecze jonowe stały się obiektem zainteresowania naukowców. Znajdują one coraz to szersze zastosowanie. Dlatego też ważne jest określenie ich właściwości Eko-toksycznych. Aktywność anty-nowotworowa i cytotoksyczna cieczy jonowych stała się zatem ważnym aspektem badań. Artykuł podsumowuje najnowsze wyniki badań nad cytotoksycznością tych rozpuszczalników
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Volatile organic compounds in gastrointestinal stromal tumour tissue originating from patient-derived xenografts
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Potentiation of the anti-tumour effects of Photofrin®-based photodynamic therapy by localized treatment with G-CSF
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Loss of DRO1/CCDC80 in the tumor microenvironment promotes carcinogenesis
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Image Segmentation of MRI image for Brain Tumor Detection
Publicationthis research work presents a new technique for brain tumor detection by the combination of Watershed algorithm with Fuzzy K-means and Fuzzy C-means (KIFCM) clustering. The MATLAB based proposed simulation model is used to improve the computational simplicity, noise sensitivities, and accuracy rate of segmentation, detection and extraction from MR...
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Vitreous humour – routine or alternative material for analysis in forensic medicine
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Spectrum of Epithelial-Mesenchymal Transition Phenotypes in Circulating Tumour Cells from Early Breast Cancer Patients
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Gemcitabine Peptide-Based Conjugates and Their Application in Targeted Tumor Therapy
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Clinical Relevance of Circulating Tumor Cells in Prostate Cancer Management
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Current Challenges in Targeting Tumor Desmoplasia to Improve the Efficacy of Immunotherapy
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Holistic Approach to the Diagnosis and Treatment of Patients with Tumor Metastases to the Spine
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Recent advances in 3D bioprinted tumor models for personalized medicine
PublicationCancerous tumors are among the most fatal diseases worldwide, claiming nearly 10 million lives in 2020. Due to their complex and dynamic nature, modeling tumors accurately is a challenging task. Current models suffer from inadequate translation between in vitro and in vivo results, primarily due to the isotropic nature of tumors and their microenvironment's relationship. To address these limitations, hydrogel-based 3D bioprinting...
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Defect in Mitochondrial NADH-Dehydrogenase Genes in Canine Mast Cell Tumours
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Molecular differences in mitochondrial DNA genomes of dogs with malignant mammary tumours
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Molecular Diagnostics of Brain Tumours by Measuring the 5-Methylcytosine Level in Their DNA
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Higher platelet counts correlate to tumour progression and can be induced by intratumoural stroma in non-metastatic breast carcinomas
PublicationBackground Platelets support tumour progression. However, their prognostic significance and relation to circulating tumour cells (CTCs) in operable breast cancer (BrCa) are still scarcely known and, thus, merit further investigation. Methods Preoperative platelet counts (PCs) were compared with clinical data, CTCs, 65 serum cytokines and 770 immune-related transcripts obtained using the NanoString technology. Results High normal...
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Cadmium, arsenic, selenium and iron– Implications for tumor progression in breast cancer
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Progress in targeting tumor cells by using drug-magnetic nanoparticles conjugate.
PublicationTo limit the cytotoxicity of anticancer drugs against healthy cells, an appropriate carrier should be synthesized to deliver the drug to the tumor tissue only. A good solution is to anchor a magnetic nanoparticle to the molecule of the drug and to use a properly directed external magnetic field. We have shown that the improved by us synthesis of the conjugate of doxorubicin with iron-oxide magnetic nanoparticles allows a substantial...
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Naturally-derived hydrogels for 3D pancreatic tumor models: A short review
PublicationStatistics suggest a high proportion of mortality rate by pancreatic cancer, which is a solid tumor characterized by high heterogeneity and the presence of a complex extracellular matrix. The very low effectiveness of pancreatic cancer treatment roots in the high metastatic potential and drug resistance of this tumor. Therefore, the quest for efficient cellular models enabling precise mimicking in vivo conditions, and anticancer...
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ColorNephroNet: Kidney tumor malignancy prediction using medical image colorization
PublicationRenal tumor malignancy classification is one of the crucial tasks in urology, being a primary factor included in the decision of whether to perform kidney removal surgery (nephrectomy) or not. Currently, tumor malignancy prediction is determined by the radiological diagnosis based on computed tomography (CT) images. However, it is estimated that up to 16% of nephrectomies could have been avoided because the tumor that had been...
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Segmentation-Based BI-RADS Ensemble Classification of Breast Tumours in Ultrasound Images
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Foetal haemoglobin-blood cells (F-cells) as a feature of embryonic tumours (blastomas)
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The aberrant overexpression of vimentin is linked to a more aggressive status in tumours of the gastrointestinal tract
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Segmentation-Based BI-RADS ensemble classification of breast tumours in ultrasound images
PublicationBackground: The development of computer-aided diagnosis systems in breast cancer imaging is exponential. Since 2016, 81 papers have described the automated segmentation of breast lesions in ultrasound images using arti- ficial intelligence. However, only two papers have dealt with complex BI-RADS classifications. Purpose: This study addresses the automatic classification of breast lesions into binary classes (benign vs. ma- lignant)...
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Keratin 7 expression in lymph node metastases but not in the primary tumour correlates with distant metastases and poor prognosis in colon carcinoma
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Modulation of CYP3A4 activity and induction of apoptosis, necrosis and senescence by the anti-tumour imidazoacridinone C-1311 in human hepatoma cells
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Analysis of Mitochondrial Genome from Labrador (Canis lupus familiaris) with Mammary Gland Tumour Reveals Novel Mutations and Polymorphisms
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Influence of narrowband ultraviolet B phototherapy on serum tumour necrosis factor-like weak inducer of apoptosis (TWEAK) in patients with psoriasis
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Capecitabine and temozolomide combination for treatment of high-grade, well-differentiated neuroendocrine tumour and poorly-differentiated neuroendocrine carcinoma — retrospective analysis
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Combined anticancer therapy with imidazoacridinone analogue C‐1305 and paclitaxel in human lung and colon cancer xenografts—Modulation of tumour angiogenesis
PublicationThe acridanone derivative 5-dimethylaminopropylamino- 8- hydroxytriazoloacridinone (C-1305) has been described as a potent inhibitor of cancer cell growth. Its mechanism of action in in vitro conditions was attributed, among others, to its ability to bind and stabilize the microtubule network and subsequently exhibit its tumour- suppressive effects in synergy with paclitaxel (PTX). Therefore, the objective of the present study...
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Adoptive Cell Therapy—Harnessing Antigen-Specific T Cells to Target Solid Tumours
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Stromal expression of ALDH1 in human breast carcinomas indicates reduced tumor progression
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Regarding the concurrent presence of secretory carcinoma and Warthin’s tumor in the ipsilateral parotid gland
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Overcome the tumor immunotherapy resistance by combination of the HDAC6 inhibitors with antitumor Immunomodulatory agents.
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Total DNA methylation as a biomarker of DNA damage and tumor malignancy in intracranial meningiomas
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Comparison of Selected Neural Network Models Used for Automatic Liver Tumor Segmentation
PublicationAutomatic and accurate segmentation of liver tumors is crucial for the diagnosis and treatment of hepatocellular carcinoma or metastases. However, the task remains challenging due to imprecise boundaries and significant variations in the shape, size, and location of tumors. The present study focuses on tumor segmentation as a more critical aspect from a medical perspective, compared to liver parenchyma segmentation, which is the...
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Comparison of the ability to induce apoptosis by acridine derivatives in solid tumor and leukemia cells
PublicationW pracy wykazano różną wrażliwość komórek nowotworowych do ulegania apoptozie pod wpływem pochodnych akrydyny.
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Evaluation of survivin splice variants in pituitary tumors
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A Novel Divisive iK-Means Algorithm with Region-Driven Feature Selection as a Tool for Automated Detection of Tumour Heterogeneity in MALDI IMS Experiments
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Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study
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Detection of circulating tumor cells by means of machine learning using Smart-Seq2 sequencing
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