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Catalog
Search results for: spółka akcyjna
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Spliced analogues of trypsin inhibitor SFTI‐1 and their application for tracing proteolysis and delivery of cargos inside the cells
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Determination of amino acids in urine of patients with prostate cancer and benign prostate growth
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Spotkanie informacyjne ws. naboru do programu Szkoły Startup
EventsZapraszamy na spotkanie informacyjne w związku z naborem do Szkoły Startup, które są dobrą okazją, aby dowiedzieć się więcej na temat programu oraz skonsultować się z kierownikiem projektu.
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Spotkanie informacyjne ws. naboru do programu Szkoły Startup
EventsZapraszamy na spotkanie informacyjne w związku z naborem do Szkoły Startup, które są dobrą okazją, aby dowiedzieć się więcej na temat programu oraz skonsultować się z kierownikiem projektu.
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Spotkanie informacyjne ws. naboru do programu Szkoły Startup
EventsSzkoła Startup zaprasza na spotkanie informacyjne na Politechnice Gdańskiej dotyczące otwartego naboru do drugiej edycji programu Startup School I, które odbędzie się w sali A.1.02 w budynku Hydromechaniki.
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Antibiotic-Based Conjugates Containing Antimicrobial HLopt2 Peptide: Design, Synthesis, Antimicrobial and Cytotoxic Activities
PublicationRecent studies have shown that modified human lactoferrin 20−31 fragment, named HLopt2, possesses antibacterial and antifungal activity. Thus, we decided to synthesize and evaluate the biological activity of a series of conjugates based on this peptide and one of the antimicrobials with proven antibacterial (ciprofloxacin, CIP, and levofloxacin, LVX) or antifungal (fluconazole, FLC) activity. The drugs were covalently connected...
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Synthesis, activity on NK-3 tachykinin receptor and conformational solution studies of scyliorhinin II analogs modified at position 16
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High prevalence of carriers of variant c.1528G>C of HADHA gene causing long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency (LCHADD) in the population of adult Kashubians from North Poland
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Zespół Katedry Rachunku Prawdopodobieństwa i Biomatematyki
Research Teams* modele ryzyka i ich zastosowania * probabilistyczne i grafowe metody w biologii * stochastyczne równania różniczkowe * statystyczna analiza danych * teoria grafów * teoria i zastosowania stochastycznych układów dynamicznych w biologii i medycynie
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2LIPP 2ND LIFE FOR POWER PLANTS
ProjectsProject realized in Zakład Systemów i Urządzeń Energetyki Cieplnej from 2022-12-13
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Design and synthesis of new substrates of HtrA2 protease
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PEGylated substrates of NSP4 protease: A tool to study protease specificity
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Relationship between copper(ii) complexes with FomA adhesin fragments ofF. nucleatumand colorectal cancer. Coordination pattern and ability to promote ROS production
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Synthesis of Novel Arginine Building Blocks with Increased Lipophilicity Compatible with Solid-Phase Peptide Synthesis
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Copper(II) complexes with Fusobacterium nucleatum adhesin FadA: Coordination pattern, physicochemical properties and reactivity
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Podatkowe determinanty sukcesu przedsiębiorcy
PublicationW rozdziale pierwszym omówiono różne definicje pojęcia „przedsiębiorczość” funkcjonujące w literaturze przedmiotu. Wskazano także istotę analizowanego zjawiska oraz uwarunkowania jego rozwoju. W drugim rozdziale omówiono kwestie związane z problematyką podatkową, z którą styka się niemal codziennie prawie każdy przedsiębiorca prowadzący działalność gospodarczą. Zaprezentowana tutaj między innymi możliwość wyboru formy prawnej i...
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Safe-by-Design Ligand-Coated ZnO Nanocrystals Engineered by an Organometallic Approach: Unique Physicochemical Properties and Low Toxicity toward Lung Cells
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Substrate specificity of human matriptase-2
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Anti-inflammatory Activity and Phytochemical Profile of Galinsoga Parviflora Cav.
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Conservation of Farmland Birds Faces Different Challenges in Western and Central-Eastern Europe
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Methodology of Selecting the Optimal Receptor to Create an Electrochemical Immunosensor for Equine Arteritis Virus Protein Detection
PublicationThe study reports a methodology of selecting the optimal receptor to create an electrochemical immunosensor for equine arteritis virus (EAV) protein detection. The detection was based on antigen recognition by antibodies immobilized on gold electrodes. Modification steps were controlled by electrochemical impedance spectroscopy and cyclic voltammetry measurements. In order to obtain the impedance immunosensor with the best parameters,...
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Methodology of Selecting the Optimal Receptor to Create an Electrochemical Immunosensor for Equine Arteritis Virus Protein Detection
PublicationThe study reports a methodology of selecting the optimal receptor to create an electrochemical immunosensor for equine arteritis virus (EAV) protein detection. The detection was based on antigen recognition by antibodies immobilized on gold electrodes. Modification steps were controlled by electrochemical impedance spectroscopy and cyclic voltammetry measurements. In order to obtain the impedance immunosensor with the best parameters,...
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Solid-phase extraction using octadecyl-bonded silica modified with photosynthetic pigments from Spinacia oleracea L. for the preconcentration of lead(II) ions from aqueous samples
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Utilization of spent iron catalyst for ammonia synthesis
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Solution conformational study of Scyliorhinin I analogues with conformational constraints by two-dimensional NMR and theoretical conformational analysis
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Serum zinc level in depressed patients during zinc supplementation of imipramine treatment
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Chronic treatment with zinc hydroaspartate induces anti-inflammatory and anti-ulcerogenic activity in rats
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Investigation of Serine‐Proteinase‐Catalyzed Peptide Splicing in Analogues of Sunflower Trypsin Inhibitor 1 (SFTI‐1)
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Truncation of Huia versabilis Bowman-Birk inhibitor increases its selectivity, matriptase-1 inhibitory activity and proteolytic stability
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Peptide conjugates of lactoferricin analogues and antimicrobials—Design, chemical synthesis, evaluation of antimicrobial activity and mammalian cytotoxicity
PublicationEight new peptide conjugates composed of modified bovine lactoferricin truncated analogues (LFcinB) and oneof the three antimicrobials — ciprofloxacin (CIP), levofloxacin (LVX), and fluconazole (FLC) — were synthesized. Four different linkers were applied to connect a peptide and an antimicrobial agent. The FLC-containing peptidic conjugates were synthesized using the “click chemistry” method. This novel approach is reported here...
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Environmental tracers and groundwater residence time indicators reveal controls of arsenic accumulation rates beneath a rapidly developing urban area in Patna, India
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Lactoferrin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity
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Lactoferricin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity
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Lactoferricin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity
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Antimicrobial Activity of Chimera Peptides Composed of Human Neutrophil Peptide 1 (HNP-1) Truncated Analogues and Bovine Lactoferrampin
PublicationThree chimera peptides composed of bovine lactoferrampin and the analogue of truncated human neutrophil peptide 1 were synthesized by the solid-phase method. In two compounds peptide chains were connected via isopeptide bond, whereas in the third one disulfide bridge served as a linker. All three chimeras displayed significantly higher antimicrobial activity than the constituent peptides as well as their equimolar mixtures. The...
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Structural Factors Affecting Cytotoxic Activity of (E)-1-(Benzo[d ][1,3]oxathiol-6-yl)-3-phenylprop-2-en-1-one Derivatives
PublicationDerivatives of (E)-1-(5-alkoxybenzo[d][1,3]oxathiol-6-yl)-3-phenylprop-2-en-1-one (1) demonstrated exceptionally high in vitro cytotoxic activity, with IC50 values of the most active derivatives in the nanomolar range. To identify structural fragments necessary for the activity, several analogs deprived of selected fragments were prepared, and their cytotoxic activity was tested. It was found that the activity depends on combined effects...
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Conjugates of Ciprofloxacin and Levofloxacin with Cell-Penetrating Peptide Exhibit Antifungal Activity and Mammalian Cytotoxicity
PublicationSeven conjugates composed of well-known fluoroquinolone antibacterial agents, ciprofloxacin (CIP) or levofloxacin (LVX), and a cell-penetrating peptide transportan 10 (TP10-NH2) were synthesised. The drugs were covalently bound to the peptide via an amide bond, methylenecarbonyl moiety, or a disulfide bridge. Conjugation of fluoroquinolones to TP10-NH2 resulted in congeners demonstrating antifungal in vitro activity against human...
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Results from a Genome-Wide Association Study (GWAS) in Mastocytosis Reveal New Gene Polymorphisms Associated with WHO Subgroups
PublicationMastocytosis is rare disease in which genetic predisposition is not fully understood. The aim of this study was to analyze associations between mastocytosis and single nucleotide polymorphisms (SNPs) by a genome-wide association study (GWAS) approach. A total of 234 patients were enrolled in our study, including 141 with cutaneous mastocytosis (CM; 78 children and 63 adults) and 93 with systemic mastocytosis (SM, all adults)....
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Przemiany metaboliczne in vitro przeciwnowotworowej pochodnej imidazoakrydonu, C-1311, i jej wpływ na aktywność wybranych izoenzymów cytochromu P450
PublicationPrzedmiotem badań przedstawionych w niniejszej pracy jest aktywna przeciwnowotworowo pochodna należąca do grupy imidazoakrydonów, tj. C-1311, i jej analog 8-metoksylowy, związek C-1330, zsyntetyzowane w Katedrze Technologii Leków i Biochemii Politechniki Gdańskiej. Wstępne badania wykazały brak wyraźnej reaktywności C-1311 i C-1330 wobec wybranych rekombinantowych ludzkich izoenzymów cytochromu P450,...
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Effective Drug Concentration and Selectivity Depends on Fraction of Primitive Cells
PublicationPoor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has been driving the search for more active and specific compounds. In this work, we show how cell density-dependent stage culture profiles can be used in drug development workflows to achieve more robust drug activity (IC50 and EC50) results. Using flow cytometry and light microscopy, we characterized the cytological stage profiles of the HL-60-,...
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Substrate specificity of Staphylococcus aureus cysteine proteases – Staphopains A, B and C
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AIMS5.0 Artificial Intelligence in Manufacturing leading to Sustainability and Industry5.0
ProjectsProject realized in Department of Microwave and Antenna Engineering
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AIMS5.0 Artificial Intelligence in Manufacturing leading to Sustainability and Industry5.0
ProjectsProject realized in Department of Microwave and Antenna Engineering
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Fluorescent analogs of trypsin inhibitor SFTI-1 isolated from sunflower seeds-synthesis and applications
PublicationThis article describes the synthesis and enzymatic study of newly synthesized analogs of trypsin inhibitors SFTI-1 that were fluorescent labeled on their N-terminal amino groups. Two fluorescent derivatives of benzoxazole (3-[2-(4-diphenylaminophenyl) benzoxazol-5-yl]-L-alanine[(4NPh(2)) Ph] Box-Ala and 3-[2-(2', 4', 5'-trimethoxyphenyl) benzoxazol-5-yl]-l-alanine-[2,4,5-(OMe)3Ph] Box-Ala) were used as efficient fluorescent labels....
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START-UP HEROES
ProjectsProject realized in Department of Mechanics and Mechatronics according to 14/SH/2018 agreement
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Dual-Activity Fluoroquinolone-Transportan 10 Conjugates offer alternative Leukemia therapy during Hematopoietic Cell Transplantation
PublicationHematopoietic cell transplantation (HCT) is often considered a last resort leukemia treatment, fraught with limited success due to microbial infections, a leading cause of mortality in leukemia patients. To address this critical issue, we explored a novel approach by synthesizing antileukemic agents containing antibacterial substances. This innovative strategy involves conjugating fluoroquinolone antibiotics, such as ciprofloxacin...
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Biochemical and Structural Characterization of SplD Protease from Staphylococcus aureus
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AGRARSENSE Smart, digitalized components and systems for data-based Agriculture and Forestry
ProjectsProject realized in Department of Microwave and Antenna Engineering according to KDT/2021/7/AGRARSENSE/2023 agreement
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AGRARSENSE Smart, digitalized components and systems for data-based Agriculture and Forestry
ProjectsProject realized in Department of Microwave and Antenna Engineering
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O niezwykłych relacjach ludzi i algorytmów Google i FB
EventsDr hab. Jan Kreft, prof. uczelni (WZiE) opowie o niezwykłych relacjach ludzi i algorytmów Google'a i Facebooka. Omówi nową inkarnację władzy – społecznych algorytmów, które mają wpływ na każdą sferę życia społecznego.