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Search results for: ŻUCHWA
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Angiopoietin-like growth factor-derived peptides as biological activators of adipose-derived mesenchymal stromal cells
PublicationAdipose-derived mesenchymal stromal cells (AD-MSCs) are an essential issue in modern medicine. Extensive preclinical and clinical studies have shown that mesenchymal stromal/stem cells, including AD-MSCs, have specific properties (ability to differentiate into other cells, recruitment to the site of injury) of particular importance in the regenerative process. Ongoing research aims to elucidate factors supporting AD-MSC culture...
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Przetwarzanie Rozproszone 2022/2023
e-Learning Courses{mlang pl}Przetwarzanie równoległe i rozproszone{mlang}{mlang en}Concurrent and Distributed Processing{mlang}
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Techniki wytwarzania, PG_00055442,W/L,MTR, sem. 04, letni 23/24
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Stratus Generation and emission of high-power electromagnetic pulses system for UAV activity counteraction.
ProjectsProject realized in Katedra Elektrotechniki according to DOB-SZAFIR/02/B/004/04/2021 agreement from 2023-07-31
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Truncation of Huia versabilis Bowman-Birk inhibitor increases its selectivity, matriptase-1 inhibitory activity and proteolytic stability
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2022/2023 - Seminarium Dyplomowe Magisterskie KASK
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Metody badawcze w informatyce 2021/2022
e-Learning CoursesPrzedmiot "metody badawcze w informatyce" uczy, czym są badania naukowe, jak je prowadzić, jak zbierać dane badawcze, analizować dane, opracowywać wyniki oraz raportować badania. Omawia wiele metod badawczych takich jak: systematyczny przegląd literatury (SLR), wywiady, ankiety, grupy fokusowe, eksperymenty, action research i inne.
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Interleukin 12 and indomethacin exert a synergistic, angiogenesis-dependent antitumor activity in mice
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Lactoferrin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity
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Lactoferricin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity
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Lactoferricin B Combined with Antibiotics Exhibits Leukemic Selectivity and Antimicrobial Activity
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Peptide conjugates of lactoferricin analogues and antimicrobials—Design, chemical synthesis, evaluation of antimicrobial activity and mammalian cytotoxicity
PublicationEight new peptide conjugates composed of modified bovine lactoferricin truncated analogues (LFcinB) and oneof the three antimicrobials — ciprofloxacin (CIP), levofloxacin (LVX), and fluconazole (FLC) — were synthesized. Four different linkers were applied to connect a peptide and an antimicrobial agent. The FLC-containing peptidic conjugates were synthesized using the “click chemistry” method. This novel approach is reported here...
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Analysis of the Link between the Redox State and Enzymatic Activity of the HtrA (DegP) Protein from Escherichia coli
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Antimicrobial Activity of Chimera Peptides Composed of Human Neutrophil Peptide 1 (HNP-1) Truncated Analogues and Bovine Lactoferrampin
PublicationThree chimera peptides composed of bovine lactoferrampin and the analogue of truncated human neutrophil peptide 1 were synthesized by the solid-phase method. In two compounds peptide chains were connected via isopeptide bond, whereas in the third one disulfide bridge served as a linker. All three chimeras displayed significantly higher antimicrobial activity than the constituent peptides as well as their equimolar mixtures. The...
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Conjugates of Ciprofloxacin and Levofloxacin with Cell-Penetrating Peptide Exhibit Antifungal Activity and Mammalian Cytotoxicity
PublicationSeven conjugates composed of well-known fluoroquinolone antibacterial agents, ciprofloxacin (CIP) or levofloxacin (LVX), and a cell-penetrating peptide transportan 10 (TP10-NH2) were synthesised. The drugs were covalently bound to the peptide via an amide bond, methylenecarbonyl moiety, or a disulfide bridge. Conjugation of fluoroquinolones to TP10-NH2 resulted in congeners demonstrating antifungal in vitro activity against human...
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Premature cardiovascular mortality in lymphoma patients treated with (R)-CHOP regimen — A national multicenter study
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Acute decompensated heart failure as a reason of premature chemotherapy discontinuation may be independent of a lifetime doxorubicin dose in lymphoma patients with cardiovascular disorders
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Dynamics of Oxidative Damage at Early Stages of Estrogen-dependant Carcinogenesis
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Effective Drug Concentration and Selectivity Depends on Fraction of Primitive Cells
PublicationPoor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has been driving the search for more active and specific compounds. In this work, we show how cell density-dependent stage culture profiles can be used in drug development workflows to achieve more robust drug activity (IC50 and EC50) results. Using flow cytometry and light microscopy, we characterized the cytological stage profiles of the HL-60-,...
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Platformy technologiczne inż. stac. - 2021/22
e-Learning Coursesstudia inżynierskie stacjonarne, kierunek Informatyka, sem. 4
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Clinical Relevance of Gut Microbiota Alterations under the Influence of Selected Drugs—Updated Review
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Przetwarzanie Rozproszone 2023/2024
e-Learning Courses{mlang pl}Przetwarzanie równoległe i rozproszone{mlang}{mlang en}Concurrent and Distributed Processing{mlang}
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Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice
PublicationThe ear pinna is a complex tissue consisting of the dermis, cartilage, muscles, vessels, and nerves. Ear pinna healing is a model of regeneration in mammals. In some mammals, including rabbits, punch wounds in the ear pinna close spontaneously; in common-use laboratory mice, they remain for life. Agents inducing ear pinna healing are potential regenerative drugs. We tested the effects of selected bioactive agents on 2 mm ear pinna...
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Emerging Role of Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Disease—Insights from the 2022 ESC Guidelines
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Efficacy of high-dose corticosteroid-based treatment for chronic lymphocytic leukemia patients with p53 abnormalities in the era of B-cell receptor inhibitors
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Efficacy of daratumumab monotherapy in real-world heavily pretreated patients with relapsed or refractory multiple myeloma
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Polish Lymphoma Research Group Experience With Bexarotene in the Treatment of Cutaneous T-Cell Lymphoma
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MIKROBIOLOGIA OGÓLNA
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PTD4 Peptide Increases Neural Viability in an In Vitro Model of Acute Ischemic Stroke
PublicationIschemic stroke is a disturbance in cerebral blood flow caused by brain tissue ischemia and hypoxia. We optimized a multifactorial in vitro model of acute ischemic stroke using rat primary neural cultures. This model was exploited to investigate the pro-viable activity of cell-penetrating peptides: arginine-rich Tat(49–57)-NH2 (R49KKRRQRRR57-amide) and its less basic analogue, PTD4 (Y47ARAAARQARA57-amide). Our model included glucose...
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Dual-Activity Fluoroquinolone-Transportan 10 Conjugates offer alternative Leukemia therapy during Hematopoietic Cell Transplantation
PublicationHematopoietic cell transplantation (HCT) is often considered a last resort leukemia treatment, fraught with limited success due to microbial infections, a leading cause of mortality in leukemia patients. To address this critical issue, we explored a novel approach by synthesizing antileukemic agents containing antibacterial substances. This innovative strategy involves conjugating fluoroquinolone antibiotics, such as ciprofloxacin...
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Platformy technologiczne inż. stac. - 2022/23
e-Learning Coursesstudia inżynierskie stacjonarne, kierunek Informatyka, sem. 4
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Przetwarzanie Rozproszone 2021/2022
e-Learning Courses{mlang pl}Przetwarzanie równoległe i rozproszone{mlang}{mlang en}Concurrent and Distributed Processing{mlang}
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A vector-enzymatic DNA fragment amplification-expression technology for construction of artificial, concatemeric DNA, RNA and proteins for novel biomaterials, biomedical and industrial applications
PublicationA DNA fragment amplification/expression technology for the production of new generation biomaterials for scientific, industrial and biomedical applications is described. The technology enables the formation of artificial Open Reading Frames (ORFs) encoding concatemeric RNAs and proteins. It recruits the Type IIS SapI restriction endonuclease (REase) for an assembling of DNA fragments in an ordered head-to-tail-orientation. The...
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Data regarding a new, vector-enzymatic DNA fragment amplification-expression technology for the construction of artificial, concatemeric DNA, RNA and proteins, as well as biological effects of selected polypeptides obtained using this method
PublicationApplications of bioactive peptides and polypeptides are emerging in areas such as drug development and drug delivery systems. These compounds are bioactive, biocompatible and represent a wide range of chemical properties, enabling further adjustments of obtained biomaterials. However, delivering large quantities of peptide derivatives is still challenging. Several methods have been developed for the production of concatemers –...
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Kardioonkologia w praktyce klinicznej
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Epigenetic inhibitor zebularine activates ear pinna wound closure in the mouse
PublicationBackground:Most studies on regenerative medicine focus on cell-based therapies and transplantations.Small-molecule therapeutics, though proved effective in different medical conditions, have not been extensivelyinvestigated in regenerative research. It is known that healing potential decreases with development and devel-opmental changes are driven by epigenetic mechanisms, which suggests epigenetic repression of regenerativecapacity.Methods:We...
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2022/2023 - Egzamin dyplomowy w trybie zdalnym – KASK
e-Learning Coursesegzaminy dyplomowe dla studiów I i II stopnia w KASK
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Pomoc psychologiczno-pedagogiczna Dz.U.2023 po. 1798 opracowanie Marcin Niedopytalski
PublicationPomoc psychologiczno-pedagogiczna w świetle Rozporządzenia Dz.U. 2023 poz. 1798 – analiza i perspektywyAutor: Marcin Niedopytalski Pomoc psychologiczno-pedagogiczna jest jednym z kluczowych elementów wspierania uczniów w polskim systemie edukacji. Rozporządzenie Ministra Edukacji Narodowej z dnia 9 sierpnia 2017 r., w brzmieniu ustalonym jednolitym tekstem opublikowanym w Dzienniku...
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Development of a Peptide Derived from Platelet-Derived Growth Factor (PDGF-BB) into a Potential Drug Candidate for the Treatment of Wounds
PublicationObjective: This study evaluated the use of novel peptides derived from platelet-derived growth factor (PDGF-BB) as potential wound healing stimulants. One of the compounds (named PDGF2) was subjected for further research after cytotoxicity and proliferation assays on human skin cells. Further investigation included evaluation of: migration and chemotaxis of skin cells, immunological and allergic safety, the transcriptional analyses...
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Immunophenotyping and transcriptional profiling of in vitro cultured human adipose tissue derived stem cells
PublicationAdipose-derived stem cells (ASCs) have become an important research model in regenerative medicine. However, there are controversies regarding the impact of prolonged cell culture on the ASCs phenotype and their differentiation potential. Hence, we studied 10 clinical ASCs replicates from plastic and oncological surgery patients, in six-passage FBS supplemented cultures. We quantified basic mesenchymal cell surface marker transcripts...
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Concurrent DNA Copy-Number Alterations and Mutations in Genes Related to Maintenance of Genome Stability in Uninvolved Mammary Glandular Tissue from Breast Cancer Patients
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Cladribine Combined with Low-Dose Cytarabine as Frontline Treatment for Unfit Elderly Acute Myeloid Leukemia Patients: Results from a Prospective Multicenter Study of Polish Adult Leukemia Group (PALG)
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2023 Historia odkryć i wynalazków (PG_00038532)
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Kompozycja farmaceutyczna zawierająca zebularynę oraz środek leczniczy do regeneracji ran
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Koncert Zimowy
EventsNajpiękniejsze polskie kolędy i pastorałki w wykonaniu Kuby Jurzyka, Pauliny Grochowskiej (wokale), Golden Gate String Quartet i Jana Jareckiego (piano). Nie zabraknie największych świątecznych zagranicznych hitów.
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Forum Magisterskich Studiów Uzupełniających
e-Learning CoursesForum do dokonywania bieżących uzgodnień, wymiany dokumentacji, ankietyzacji i wymiany opinii NA z wydziału ETI i z PG prowadzących zajęcia na st. niest. II st. kier Informatyka oraz starostów grup studenckich tych studiów.
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Peptyd RDKVYR lub jego farmaceutycznie dopuszczalna sól do zastosowania w procesie regeneracji tkanki złożonej i gojenia się ran u ssaków
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Wektory powielająco-ekspresyjne
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Związki chemiczne o działaniu przeciwuszkodzeniowym i/lub neuroprotekcyjnym
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Nowy związek peptydowy jako czynnik stymulujący gojenie ran i rekonstrukcję skóry
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