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Search results for: ŻUCHWA
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Antimicrobial Activity of Chimera Peptides Composed of Human Neutrophil Peptide 1 (HNP-1) Truncated Analogues and Bovine Lactoferrampin
PublicationThree chimera peptides composed of bovine lactoferrampin and the analogue of truncated human neutrophil peptide 1 were synthesized by the solid-phase method. In two compounds peptide chains were connected via isopeptide bond, whereas in the third one disulfide bridge served as a linker. All three chimeras displayed significantly higher antimicrobial activity than the constituent peptides as well as their equimolar mixtures. The...
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Analysis of the Link between the Redox State and Enzymatic Activity of the HtrA (DegP) Protein from Escherichia coli
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Conjugates of Ciprofloxacin and Levofloxacin with Cell-Penetrating Peptide Exhibit Antifungal Activity and Mammalian Cytotoxicity
PublicationSeven conjugates composed of well-known fluoroquinolone antibacterial agents, ciprofloxacin (CIP) or levofloxacin (LVX), and a cell-penetrating peptide transportan 10 (TP10-NH2) were synthesised. The drugs were covalently bound to the peptide via an amide bond, methylenecarbonyl moiety, or a disulfide bridge. Conjugation of fluoroquinolones to TP10-NH2 resulted in congeners demonstrating antifungal in vitro activity against human...
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Premature cardiovascular mortality in lymphoma patients treated with (R)-CHOP regimen — A national multicenter study
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Acute decompensated heart failure as a reason of premature chemotherapy discontinuation may be independent of a lifetime doxorubicin dose in lymphoma patients with cardiovascular disorders
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Platformy technologiczne inż. stac. - 2021/22
e-Learning Coursesstudia inżynierskie stacjonarne, kierunek Informatyka, sem. 4
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Dynamics of Oxidative Damage at Early Stages of Estrogen-dependant Carcinogenesis
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Effective Drug Concentration and Selectivity Depends on Fraction of Primitive Cells
PublicationPoor efficiency of chemotherapeutics in the eradication of Cancer Stem Cells (CSCs) has been driving the search for more active and specific compounds. In this work, we show how cell density-dependent stage culture profiles can be used in drug development workflows to achieve more robust drug activity (IC50 and EC50) results. Using flow cytometry and light microscopy, we characterized the cytological stage profiles of the HL-60-,...
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Przetwarzanie Rozproszone 2023/2024
e-Learning Courses{mlang pl}Przetwarzanie równoległe i rozproszone{mlang}{mlang en}Concurrent and Distributed Processing{mlang}
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Clinical Relevance of Gut Microbiota Alterations under the Influence of Selected Drugs—Updated Review
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Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice
PublicationThe ear pinna is a complex tissue consisting of the dermis, cartilage, muscles, vessels, and nerves. Ear pinna healing is a model of regeneration in mammals. In some mammals, including rabbits, punch wounds in the ear pinna close spontaneously; in common-use laboratory mice, they remain for life. Agents inducing ear pinna healing are potential regenerative drugs. We tested the effects of selected bioactive agents on 2 mm ear pinna...
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Efficacy of high-dose corticosteroid-based treatment for chronic lymphocytic leukemia patients with p53 abnormalities in the era of B-cell receptor inhibitors
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Efficacy of daratumumab monotherapy in real-world heavily pretreated patients with relapsed or refractory multiple myeloma
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Polish Lymphoma Research Group Experience With Bexarotene in the Treatment of Cutaneous T-Cell Lymphoma
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Dual-Activity Fluoroquinolone-Transportan 10 Conjugates offer alternative Leukemia therapy during Hematopoietic Cell Transplantation
PublicationHematopoietic cell transplantation (HCT) is often considered a last resort leukemia treatment, fraught with limited success due to microbial infections, a leading cause of mortality in leukemia patients. To address this critical issue, we explored a novel approach by synthesizing antileukemic agents containing antibacterial substances. This innovative strategy involves conjugating fluoroquinolone antibiotics, such as ciprofloxacin...
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PTD4 Peptide Increases Neural Viability in an In Vitro Model of Acute Ischemic Stroke
PublicationIschemic stroke is a disturbance in cerebral blood flow caused by brain tissue ischemia and hypoxia. We optimized a multifactorial in vitro model of acute ischemic stroke using rat primary neural cultures. This model was exploited to investigate the pro-viable activity of cell-penetrating peptides: arginine-rich Tat(49–57)-NH2 (R49KKRRQRRR57-amide) and its less basic analogue, PTD4 (Y47ARAAARQARA57-amide). Our model included glucose...
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Platformy technologiczne inż. stac. - 2022/23
e-Learning Coursesstudia inżynierskie stacjonarne, kierunek Informatyka, sem. 4
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Przetwarzanie Rozproszone 2021/2022
e-Learning Courses{mlang pl}Przetwarzanie równoległe i rozproszone{mlang}{mlang en}Concurrent and Distributed Processing{mlang}
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A vector-enzymatic DNA fragment amplification-expression technology for construction of artificial, concatemeric DNA, RNA and proteins for novel biomaterials, biomedical and industrial applications
PublicationA DNA fragment amplification/expression technology for the production of new generation biomaterials for scientific, industrial and biomedical applications is described. The technology enables the formation of artificial Open Reading Frames (ORFs) encoding concatemeric RNAs and proteins. It recruits the Type IIS SapI restriction endonuclease (REase) for an assembling of DNA fragments in an ordered head-to-tail-orientation. The...
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Data regarding a new, vector-enzymatic DNA fragment amplification-expression technology for the construction of artificial, concatemeric DNA, RNA and proteins, as well as biological effects of selected polypeptides obtained using this method
PublicationApplications of bioactive peptides and polypeptides are emerging in areas such as drug development and drug delivery systems. These compounds are bioactive, biocompatible and represent a wide range of chemical properties, enabling further adjustments of obtained biomaterials. However, delivering large quantities of peptide derivatives is still challenging. Several methods have been developed for the production of concatemers –...
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2022/2023 - Egzamin dyplomowy w trybie zdalnym – KASK
e-Learning Coursesegzaminy dyplomowe dla studiów I i II stopnia w KASK
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Epigenetic inhibitor zebularine activates ear pinna wound closure in the mouse
PublicationBackground:Most studies on regenerative medicine focus on cell-based therapies and transplantations.Small-molecule therapeutics, though proved effective in different medical conditions, have not been extensivelyinvestigated in regenerative research. It is known that healing potential decreases with development and devel-opmental changes are driven by epigenetic mechanisms, which suggests epigenetic repression of regenerativecapacity.Methods:We...
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Immunophenotyping and transcriptional profiling of in vitro cultured human adipose tissue derived stem cells
PublicationAdipose-derived stem cells (ASCs) have become an important research model in regenerative medicine. However, there are controversies regarding the impact of prolonged cell culture on the ASCs phenotype and their differentiation potential. Hence, we studied 10 clinical ASCs replicates from plastic and oncological surgery patients, in six-passage FBS supplemented cultures. We quantified basic mesenchymal cell surface marker transcripts...
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Development of a Peptide Derived from Platelet-Derived Growth Factor (PDGF-BB) into a Potential Drug Candidate for the Treatment of Wounds
PublicationObjective: This study evaluated the use of novel peptides derived from platelet-derived growth factor (PDGF-BB) as potential wound healing stimulants. One of the compounds (named PDGF2) was subjected for further research after cytotoxicity and proliferation assays on human skin cells. Further investigation included evaluation of: migration and chemotaxis of skin cells, immunological and allergic safety, the transcriptional analyses...
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Concurrent DNA Copy-Number Alterations and Mutations in Genes Related to Maintenance of Genome Stability in Uninvolved Mammary Glandular Tissue from Breast Cancer Patients
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Cladribine Combined with Low-Dose Cytarabine as Frontline Treatment for Unfit Elderly Acute Myeloid Leukemia Patients: Results from a Prospective Multicenter Study of Polish Adult Leukemia Group (PALG)
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2023 Historia odkryć i wynalazków (PG_00038532)
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Kompozycja farmaceutyczna zawierająca zebularynę oraz środek leczniczy do regeneracji ran
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Koncert Zimowy
EventsNajpiękniejsze polskie kolędy i pastorałki w wykonaniu Kuby Jurzyka, Pauliny Grochowskiej (wokale), Golden Gate String Quartet i Jana Jareckiego (piano). Nie zabraknie największych świątecznych zagranicznych hitów.
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Forum Magisterskich Studiów Uzupełniających
e-Learning CoursesForum do dokonywania bieżących uzgodnień, wymiany dokumentacji, ankietyzacji i wymiany opinii NA z wydziału ETI i z PG prowadzących zajęcia na st. niest. II st. kier Informatyka oraz starostów grup studenckich tych studiów.
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Peptyd RDKVYR lub jego farmaceutycznie dopuszczalna sól do zastosowania w procesie regeneracji tkanki złożonej i gojenia się ran u ssaków
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Wektory powielająco-ekspresyjne
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Związki chemiczne o działaniu przeciwuszkodzeniowym i/lub neuroprotekcyjnym
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Nowy związek peptydowy jako czynnik stymulujący gojenie ran i rekonstrukcję skóry
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Peptyd, będący fragmentem płytkopochodnego czynnika wzrostu do zastosowania jako środek leczniczy do podania na skórę w zaburzeniech naskóreka do stymulacji odbudowy naskórka
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Kurs przygotowawczy do matury
e-Learning CoursesProgram kursu z fizyki: Wielkości fizyczne, wektory i skalary, pomiary wielkości fizycznych, metodologia sporządzania tabel i wykresów, niepewności pomiarowe, planowanie prostych eksperymentów. Podstawowe pojęcia kinematyki punktu materialnego, układ odniesienia, wektor wodzący, tor ruchu, równanie ruchu, ruch prostoliniowy, ruch krzywoliniowy, droga, przemieszczenie, prędkość średnia, prędkość chwilowa, szybkość, przyspieszenie...
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Projekt grupowy II (luty 2023)
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Projekt grupowy II (październik 2023) - kurs uzupełniający
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Projekt grupowy I (wrzesień 2022)
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Projekt grupowy I (październik 2023)
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Projekt grupowy II (luty 2024)
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40th EASD Annual Meeting of the European Association for the Study of Diabetes
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