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Search results for: PSORIASIS GENETICS, GWAS, EPIGENETIC CHANGES, MIRNA
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Pathogenesis of psoriasis in the “omic” era. Part II. Genetic, genomic and epigenetic changes in psoriasis
PublicationPsoriasis is a multifactorial disease in which genetic, environmental and epigenetic factors regulating gene expression play a key role. In the “genomic era”, genome-wide association studies together with target genotyping platforms performed in different ethnic populations have found more than 50 genetic susceptible markers associated with the risk of psoriasis which have been identified so far. Up till now, the strongest association...
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The hypoxia‐induced changes in miRNA‐mRNA in RNA ‐induced silencing complexes and HIF ‐2 induced miRNAs in human endothelial cells
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mRNA adenosine methylase (MTA) deposits m 6 A on pri-miRNAs to modulate miRNA biogenesis in Arabidopsis thaliana
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Genetics & Epigenetics
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Journal of Psoriasis and Psoriatic Arthritis
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Genetic and Epigenetic Aspects of Atopic Dermatitis
PublicationAtopic dermatitis is a heterogeneous disease, in which the pathogenesis is associated with mutations in genes encoding epidermal structural proteins, barrier enzymes, and their inhibitors; the role of genes regulating innate and adaptive immune responses and environmental factors inducing the disease is also noted. Recent studies point to the key role of epigenetic changes in the development of the disease. Epigenetic modifications...
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SiMiSnoRNA: Collection of siRNA, miRNA, and snoRNA database for RNA Interference
PublicationObjective:The discovery of sequence specific gene silencing which occurs due to the presence of double-stranded RNAs has considerable impact on biology, revealing an unknown level of regulation of gene expression. This process is known as RNA interference (RNAi) or RNA silencing in which RNA molecules inhibit gene expression, typically by causing the destruction of specific mRNA molecule. Two types of small RNA molecules - small...
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Proteomic and Metabolomic Changes in Psoriasis Preclinical and Clinical Aspects
PublicationSkin diseases such as psoriasis (Ps) and psoriatic arthritis (PsA) are immune-mediated inflammatory diseases. Overlap of autoinflammatory and autoimmune conditions hinders diagnoses and identifying personalized patient treatments due to different psoriasis subtypes and the lack of verified biomarkers. Recently, proteomics and metabolomics have been intensively investigated in a broad range of skin diseases with the main purpose...
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Nanosized zinc, epigenetic changes and its relationship with DMBA induced breast cancer in rats
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Epigenetic-Based Therapy—A Prospective Chance for Medulloblastoma Patients’ Recovery
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Ecological Genetics and Genomics
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Journal of Genetics and Genomics
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MOLECULAR GENETICS AND GENOMICS
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Charge Loss in Gas-Phase Multiply Negatively Charged Oligonucleotides
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The Role of miRNA in Papillary Thyroid Cancer in the Context of miRNA Let-7 Family
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Recent Insights into Plant miRNA Biogenesis: Multiple Layers of miRNA Level Regulation
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Psoriasis-Targets and Therapy
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Changes in Epigenetic Patterns Related to DNA Replication in Vicia faba Root Meristem Cells under Cadmium-Induced Stress Conditions
PublicationExperiments on Vicia faba root meristem cells exposed to 150 µM cadmium chloride (CdCl2) were undertaken to analyse epigenetic changes, mainly with respect to DNA replication stress. Histone modifications examined by means of immunofluorescence labeling included: (1) acetylation of histone H3 on lysine 56 (H3K56Ac), involved in transcription, S phase, and response to DNA damage during DNA biosynthesis; (2) dimethylation of histone...
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Human Genetics and Genomics Advances
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Psoriasis and cardiometabolic disorders
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Sleep disorders in psoriasis
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The role of lipids in psoriasis
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The role of epigenetics in regeneration
PublicationComplex changes in chromatin structure and at the transcriptional level occur from the creation of a single parental gamete throughout fertilization, embryo development and the life of an adult organism. Epigenetic changes, such as methylation and hydroxymethylation of DNA or histone methylation and acetylation, are an important part of these processes. Epigenetic regulation has an essential influence on gene expression level. DNA...
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Pathogenesis of psoriasis in the “omic” era. Part III. Metabolic disorders, metabolomics, nutrigenomics in psoriasis
PublicationPsoriasis is a systemic disease that is strictly connected with metabolic disorders (insulin resistance, atherogenic dyslipidemia, arterial hypertension, and cardiovascular diseases). It occurs more often in patients with a more severe course of the disease. Obesity is specially an independent risk factor and it is associated with a worse treatment outcome because of the high inflammatory activity of visceral fatty tissue and...
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Models in the Research Process of Psoriasis
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Selected aspects of apoptosis in psoriasis
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Posttranscriptional coordination of splicing and miRNA biogenesis in plants
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Epigenetics & Chromatin
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EPIGENETICS-US
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Epigenetics Insights
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Environmental Epigenetics
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Annual Review of Genomics and Human Genetics
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Aberrations in Lipid Expression and Metabolism in Psoriasis
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Serum irisin levels in patients with psoriasis
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Analysis of epigenetic clocks links yoga, sleep, education, reduced meat intake, coffee, and a SOCS2 gene variant to slower epigenetic aging
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Urinary Measurement of Epigenetic DNA Modifications: A Non-Invasive Assessment of the Whole-Body Epigenetic Status in Healthy Subjects and Colorectal Cancer Patients
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JOURNAL OF APPLIED GENETICS
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Jan Domaradzki dr hab.
PeopleDr Jan Domaradzki is an assistant professor of sociology and Head of the Laboratory of Health Sociology and Social Pathology at the Department of Social Sciences and Humanities, Poznan University of Medical Sciences, Poznań, Poland. He is a sociologist with an interest in medical sociology; sociology of genetics; social implications of a new genetics, medicalization and geneticization, social representations of biotechnology, social...
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A New Epigenetic Mechanism of Temozolomide Action in Glioma Cells
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A Single Mutation in a Tunnel to the Active Site Changes the Mechanism and Kinetics of Product Release in Haloalkane Dehalogenase LinB*
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The Role of miRNA-7 in the Biology of Cancer and Modulation of Drug Resistance
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Oxidative Stress as an Important Contributor to the Pathogenesis of Psoriasis
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Factors affecting response to biologic treatment in psoriasis
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GENETICS
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Inorganic membrane: a game changer for gas separation and purification
PublicationThis review explores the advancements and remaining challenges in inorganic membrane science, particularly focusing on their potential for industrial applications. It delves into the fundamental principles of inorganic membrane design, fabrication, and characterization techniques. The review also critically analyzes key challenges faced by inorganic membranes, such as physical aging, plasticization, defective formation, and fouling....
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Global DNA demethylation as an epigenetic marker of human brain metastases
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Paweł Huelle, Mina
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Diagnostic potential for a serum miRNA neural network for detection of ovarian cancer
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Unbalanced Sphingolipid Metabolism and Its Implications for the Pathogenesis of Psoriasis
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Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations
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