Search results for: melanoma
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Transplantable Melanomas in Hamsters and Gerbils as Models for Human Melanoma. Sensitization in Melanoma Radiotherapy—From Animal Models to Clinical Trials
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Melanoma Management
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MELANOMA RESEARCH
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The role of melanin pigment in melanoma
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Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management
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Proteomic profile of melanoma cell‐derived small extracellular vesicles in patients’ plasma: a potential correlate of melanoma progression
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Intelligent system supporting diagnosis of malignant melanoma
PublicationMalignant melanomas are the most deadly type of skin cancers. Early diagnosis is a key for successful treatment and survival. The paper presents the system for supporting the process of diagnosis of skin lesions in order to detect a malignant melanoma. The paper describes the development process of an intel-ligent system purposed for the diagnosis of malignant melanoma. Presented sys-tem can be used as a decision support system...
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Common variants of DNA repair genes and malignant melanoma
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New vitamin D analogs as potential therapeutics in melanoma
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XPD Common Variants and their Association with Melanoma and Breast Cancer Risk
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Proteomic Analysis of Proton Beam Irradiated Human Melanoma Cells
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Liquid Biopsy in Melanoma: Significance in Diagnostics, Prediction and Treatment Monitoring
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The assessment of students’ knowledge regarding melanoma and sun-protection habits
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MC1R common variants, CDKN2A and their association with melanoma and breast cancer risk
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ELECTROCHEMOTHERAPY COMBINED WITH STANDARD AND CO2 LASER SURGERIES IN CANINE ORAL MELANOMA
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On the role of classical and novel forms of vitamin D in melanoma progression and management
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Melanoma skin cancer detection using mask-RCNN with modified GRU model
PublicationIntroduction: Melanoma Skin Cancer (MSC) is a type of cancer in the human body; therefore, early disease diagnosis is essential for reducing the mortality rate. However, dermoscopic image analysis poses challenges due to factors such as color illumination, light reflections, and the varying sizes and shapes of lesions. To overcome these challenges, an automated framework is proposed in this manuscript. Methods: Initially, dermoscopic...
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Fluorescence Imaging Using Methylene Blue Sentinel Lymph Node Biopsy in Melanoma
PublicationIntroduction: Fluorescence imaging of sentinel node biopsy in melanoma is a novel method. Both indocyanine green (ICG) and methylene blue (MB) have fl uorescent properties. The aim of this study was to present, for the fi rst time in a clinical series of patients, the possible usage of MB as a fl uorescent dye for sentinel node biopsy during surgery for melanoma. Material and methods: Twenty patients with...
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Novel therapeutic compound acridine–retrotuftsin action on biological forms of melanoma and neuroblastoma
PublicationPURPOSE: As a continuation of our search for anticancer agents, we have synthesized a new acridine-retrotuftsin analog HClx9-[Arg(NO2)-Pro-Lys-Thr-OCH3]-1-nitroacridine (named ART) and have evaluated its activity against melanoma and neuroblastoma lines. Both tumors develop from cells (melanocytes, neurons) of neuroectodermal origin, and both are tumors with high heterogeneity and unsatisfactory susceptibility to chemotherapies....
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Anticancer properties of ester derivatives of betulin in human metastatic melanoma cells (Me-45)
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The effects of p53 gene inactivation on mutant proteome expression in a human melanoma cell model
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An Insight into the Proteome of Uveal Melanoma-Derived Ectosomes Reveals the Presence of Potentially Useful Biomarkers
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Similarities and Differences in the Protein Composition of Cutaneous Melanoma Cells and Their Exosomes Identified by Mass Spectrometry
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Graphene-encapsulated iron nanoparticles as a non-viral vector for gene delivery into melanoma cells
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Polymer-free cubosomes for simultaneous bioimaging and photodynamic action of photosensitizers in melanoma skin cancer cells
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Antitumor Effects of Vitamin D Analogs on Hamster and Mouse Melanoma Cell Lines in Relation to Melanin Pigmentation
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Mass Spectrometry-Based Proteomic Characterization of Cutaneous Melanoma Ectosomes Reveals the Presence of Cancer-Related Molecules
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DEEP CONVOLUTIONAL NEURAL NETWORKS AS A DECISION SUPPORT TOOL IN MEDICAL PROBLEMS – MALIGNANT MELANOMA CASE STUDY
PublicationThe paper presents utilization of one of the latest tool from the group of Machine learning techniques, namely Deep Convolutional Neural Networks (CNN), in process of decision making in selected medical problems. After the survey of the most successful applications of CNN in solving medical problems, the paper focuses on the very difficult problem of automatic analyses of the skin lesions. The authors propose the CNN structure...
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Low prevalence of CDKN2A/ARF mutations among early-onset cancers of breast, pancreas and malignant melanoma in Poland
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DIAGNOSIS OF MALIGNANT MELANOMA BY NEURAL NETWORK ENSEMBLE-BASED SYSTEM UTILISING HAND-CRAFTED SKIN LESION FEATURES
PublicationMalignant melanomas are the most deadly type of skin cancer but detected early have high chances for successful treatment. In the last twenty years, the interest of automated melanoma recognition detection and classification dynamically increased partially because of public datasets appearing with dermatoscopic images of skin lesions. Automated computer-aided skin cancer detection in dermatoscopic images is a very challenging task...
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Fermentacja metanowa kapusty białej oraz osadu nadmiernego
PublicationW pracy przedstawiono wyniki badań fermentacji metanowej biomasy kapusty białej i osadu nadmiernego pobranego z oczyszczalni ścieków Saur Neptun Gdańsk S.A. Proces fermentacji prowadzono w warunkach mokrych, w sposób quaziciągły, w temperaturze 37°C. Zaobserwowano, że poddając fermentacji beztlenowej wsad zawierający kapustę białą oraz osad nadmierny można uzyskać biogaz o średnim składzie 50% metanu i 50% ditlenku węgla. Podczas...
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FERMENTACJA METANOWA MODELOWEGO WSADU KOMUNALNYCH ODPADÓW ORGANICZNYCH
PublicationFermentacja metanowa frakcji organicznej odpadów komunalnych pozwala na efektywny odzysk węgla z odpadów. Procesem beztlenowym jest zasadniczo fermentacja metanowa mezofilowa, jak i termofilowa, jednakże w procesie fermentacji termofilowej redukcja związków organicznych, niszczenie patogenów oraz produkcja biogazu zachodzi z większą wydajnością. Odpady komunalne charakteryzują się wysoką heterogenicznością składu, co może przyczyniać...
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Antiproliferative Activity of Double Point Modified Analogs of 1,25-Dihydroxyvitamin D2 Against Human Malignant Melanoma Cell Lines
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Photo-conversion of two epimers (20R and 20S) of pregna-5,7-diene-3β, 17α, 20-triol and their bioactivity in melanoma cells
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Synthesis and photochemical transformation of 3β,21-dihydroxypregna-5,7-dien-20-one to novel secosteroids that show anti-melanoma activity
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KO-FERMENTACJA METANOWA JAKO ALTERNATYWNA METODA ZAGOSPODAROWANIA ZANIECZYSZCZONEJ BIOMASY
PublicationJedną z przyczyn ograniczonego stosowania fitoremediacji jest powstawanie zanieczyszczonej biomasy, dla której wciąż nie opracowano odpowiedniej technologii zagospodarowania lub unieszkodliwiania. W pracy przedstawiono sposób redukcji objętości biomasy, powstającej w wyniku fitoremediacji, metodą fermentacji metanowej. Głównym zagadnieniem jest intensyfikacja produkcji biogazu w procesie ko-fermentacji dwóch lub większej liczby...
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Complete tumour regressions induced by vaccination with IL-12 gene-transduced tumour cells in combination with IL-15 in a melanoma model in mice
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Antiproliferative activity of side-chain truncated vitamin D analogs (PRI-1203 and PRI-1204) against human malignant melanoma cell lines
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Designing a High-sensitivity Microscale Triple-band Biosensor based on Terahertz MTMs to provide a perfect absorber for Non-Melanoma Skin Cancer diagnostic
PublicationNon-melanoma skin cancer (NMSC) is among the most prevalent forms of cancer originating in the top layer of the skin, with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) being its primary categories. While both types are highly treatable, the success of treatment hinges on early diagnosis. Early-stage NMSC detection can be achieved through clinical examination, typically involving visual inspection. An alternative,...
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Pigment Cell & Melanoma Research
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Melanoma, metastatic - Male, 48 - Tissue image [6120730031838031]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.
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Pulse-Modulated Radio-Frequency Alternating-Current-Driven Atmospheric-Pressure Glow Discharge for Continuous-Flow Synthesis of Silver Nanoparticles and Evaluation of Their Cytotoxicity toward Human Melanoma Cells
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Chloroacridine derivatives as potential anticancer agents which may act as tricarboxylic acid cycle enzyme inhibitors
PublicationThe chloroacridines affect biological forms of melanoma in different ways. Amelanotic (Ab) melanoma (with inhibited melanogenesis and higher malignancy) was particularly sensitive to the action of the chloroacridines. The Ab melanoma cells died through apoptosis and through death without caspase activation. Diminished activity of TAC enzymes was noticed among Ab melanoma cells together with ATP/NAD depletion, especially in the...
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Synthesis and Biological Evaluation of Acridine/Acridone Analogs as Potential Anticancer Agents
PublicationAcridine and acridone analogues were prepared by Ullmann condensation and then cyclization reaction. As a result of nucleophilic substitution reaction 1-nitro-9-phenoxyacridine or 1-chloro-4-nitro-9(10H)-acridone with the corresponding peptides, the planned acridine derivatives (10a-c, 12, 17-a-d, 19) have been obtained. The cytotoxic activity of the newly obtained analogs were evaluated against melanotic (Ma) and amelanotic (Ab)...
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Melanoma, metastatic - Male, 48 - Tissue image [6120730031831681]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.
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Melanoma, metastatic - Male, 48 - Tissue image [612073003183831]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.
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Melanoma, metastatic - Male, 48 - Tissue image [6120730031832641]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.
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Melanoma, metastatic - Male, 48 - Tissue image [6120730031838471]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.
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Melanoma, metastatic - Male, 48 - Tissue image [612073003183651]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.
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Melanoma, metastatic - Male, 48 - Tissue image [6120730031835241]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.