Alicja Trocka - Publikacje - MOST Wiedzy

Alicja Trocka

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Doktorantka w Politechnika Gdanska
w Katedra Chemii Organicznej

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wszystkich: 4

Rok 2024

Meldrum’s acid assisted formation of tetrahydroquinolin‑2‑one derivatives a short synthetic pathway to the biologically useful scaffold
Publikacja
- Scientific Reports - Rok 2024
A new method for the preparation of tetrahydroquinolin-2-one derivatives is presented. This approach involves a two-step reaction between enaminones and acylating agents, immediately followed by electrophilic cyclization, all within a single synthesis procedure, eliminating the need to isolate intermediates. The entire process is facilitated by the use of acyl Meldrum’s acids which not only shortens the preparation time of the...

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Synthesis and biological evaluation of novel 3,6- amide and thioamide substituted- 2,3,4,9-tetrahydro-1H-carbazoles for anti-cancer activity
Publikacja
- A. Trocka
- A. Kallingal
- N. Maciejewska
- N. Magdalena
- A. Hromova
- S. Makowiec
- EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - Rok 2024
Herein, we report the synthesis of new compounds with demonstrated anticancer properties based on the 2,3,4,9- tetrahydro-1H-carbazole scaffold. The Fischer indolization method was used to close the heterocyclic motif. The synthesis method’s scope and limitations were thoroughly assessed through a series of experiments. Biological assays revealed that two thioamide compounds exhibited significant anticancer activity against MCF-7,...

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Rok 2022

Application of the 2-deoxyglucose scaffold as a new chiral probe for elucidation of the absolute configuration of secondary alcohols
Publikacja
- Scientific Reports - Rok 2022
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Application of the 2-deoxyglucose scaffold as a new chiral probe for elucidation of the absolute configuration of secondary alcohols
Publikacja
- Scientific Reports - Rok 2022
Herein, we present the application of 2-deoxy-D-glucose derivatives as chiral probes for elucidation of the absolute configuration of chiral secondary alcohols. The probes are attached to the studied molecules via glycosylation reaction and the resulting products are examined by a set of standard 2D NMR experiments. The absolute configuration of an oxymethine carbon atom binding the probe is established on a basis of a set of diagnostic...

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