Chitosan-Nanogold and Chitosan-Nanozinc Electrodeposited Coatings for Biomedical Applications - Publikacja - MOST Wiedzy

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Chitosan-Nanogold and Chitosan-Nanozinc Electrodeposited Coatings for Biomedical Applications

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Bacterial infections represent a significant challenge to the success rate of both short- and long-term titanium implants.Consequently, there is a persistent need for effective strategies to prevent such infections. In this study, chitosan-based coatingsmodified with gold or zinc nanoparticles, recognized for their antibacterial properties, were electrophoretically deposited (EPD)onto the Ti13Zr13Nb alloy and thoroughly characterized. The effects of EPD voltage, surfactant use, and metallic nanoparticletype and concentration were investigated with regard to the microstructure and properties of the obtained chitosan-based coat-ings. Incorporating metallic nanoparticles into the chitosan matrix increased surface roughness (from 54 nm to even 146 nm),particularly at higher EPD voltages, resulting in a composite structure containing nanometal clusters. The addition of gold nano-particles reduced the thickness of the coatings (from 3.90 μm for the chitosan coating with Tween20–3.43 μm); zinc had no effect.Reducing the deposition voltage from 20 V to 10 V resulted in a thickness reduction of around 50% for all tested modifications.The improvement in plastic deformation resistance (indicated by the H 3/E 2 ratio) was demonstrated for gold and zinc coatingsdeposited at lower voltages (from 0.34 MPa for the chitosan coating with Tween20 to 1.00 MPa for the gold half and 1.78 MPa forthe zinc coating). A twofold increase in voltage resulted in a significant enhancement of coating adhesion—by approximately177% for gold-added coatings and 138% for zinc-added coatings. Biological responses were dependent upon the types and con-centrations of nanometals. Nanogold induced erythrocyte hemolysis, whereas nanozinc exhibited no adverse effects. Notably,gold-doped coatings demonstrated antibacterial efficacy against Staphylococcus aureus, while zinc-doped counterparts did not.Both nanometals, however, demonstrated reduced cytocompatibility at higher concentrations. Biological response tests indicatedthat 2-fold and 4-fold dilutions of the extracted medium do not show cytotoxicity for gold and zinc nanoparticles, respectively.These findings highlight the considerable extent to which coating parameters can be modified by adjusting selected EPD processparameters.

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Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS nr 113,
ISSN: 1552-4973
Język:
angielski
Rok wydania:
2025
Opis bibliograficzny:
Bartmański M., Wekwejt M., Urbanowicz K., Mielewczyk-Gryń A., Gajowiec G., Pałubicka A., Michno A., Serafin P. K., Koszałka P.: Chitosan-Nanogold and Chitosan-Nanozinc Electrodeposited Coatings for Biomedical Applications// JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS -,iss. 113/4 (2025), s.1-17
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1002/jbm.b.35571
Źródła finansowania:
Weryfikacja:
Politechnika Gdańska

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