Chronic Rhinosinusitis—Microbiological Etiology, Potential Genetic Markers, and Diagnosis - Publikacja - MOST Wiedzy

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Chronic Rhinosinusitis—Microbiological Etiology, Potential Genetic Markers, and Diagnosis

Abstrakt

Chronic rhinosinusitis (CRS) is a significant public health problem. Bacterial colonization and impaired mucociliary clearance play a significant role in the inflammatory process. Several inflammatory pathways and host defense elements are altered in CRS, which may contribute to observed differences in the microbiome. To date, researching CRS has been difficult due to limited access to the studied tissue and a lack of available biomarkers. Ongoing scientific research is increasingly based on simple and objective analytical methods, including sensors, detection with PCR, and sequencing. Future research on microbiota and human factors should also include genomics, transcriptomics, and metabolomics approaches. This report analyzes the changes that occur in the paranasal sinuses of people with acute and chronic rhinosinusitis, the composition of the microbiota, the human genetic markers that may shed light on the predisposition to CRS, and the advantages and disadvantages of classical and molecular diagnostic methods, as well as addressing the difficulties of sinusitis treatment.

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Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach dostępnych w wersji elektronicznej [także online]
Opublikowano w:
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN: 1661-6596
Język:
angielski
Rok wydania:
2024
Opis bibliograficzny:
Michalik M., Krawczyk B., Chronic Rhinosinusitis—Microbiological Etiology, Potential Genetic Markers, and Diagnosis, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024,10.3390/ijms25063201
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.3390/ijms25063201
Źródła finansowania:
  • COST_FREE
Weryfikacja:
Politechnika Gdańska

wyświetlono 19 razy

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