Electron-Induced Decomposition of 5-Bromo-4-thiouracil and 5-Bromo-4-thio-2′-deoxyuridine: The Effect of the Deoxyribose Moiety on Dissociative Electron Attachment - Publikacja - MOST Wiedzy

Twoje konto

zaloguj

Wyszukiwarka

Electron-Induced Decomposition of 5-Bromo-4-thiouracil and 5-Bromo-4-thio-2′-deoxyuridine: The Effect of the Deoxyribose Moiety on Dissociative Electron Attachment

Abstrakt

When modified uridine derivatives are incorporated into DNA, radical species may form that cause DNA damage. This category of molecules has been proposed as radiosensitizers and is currently being researched. Here, we study electron attachment to 5-bromo-4-thiouracil (BrSU), a uracil derivative, and 5-bromo-4-thio-20 -deoxyuridine (BrSdU), with an attached deoxyribose moiety via the N-glycosidic (N1-C) bond. Quadrupole mass spectrometry was used to detect the anionic products of dissociative electron attachment (DEA), and the experimental results were supported by quantum chemical calculations performed at the M062X/aug-cc-pVTZ level of theory. Experimentally, we found that BrSU predominantly captures low-energy electrons with kinetic energies near 0 eV, though the abundance of bromine anions was rather low compared to a similar experiment with bromouracil. We suggest that, for this reaction channel, proton-transfer reactions in the transient negative ions limit the release of bromine anions.

Cytowania

  • 3

    CrossRef

  • 0

    Web of Science

  • 3

    Scopus

Autorzy (7)

Cytuj jako

Pełna treść

pobierz publikację
pobrano 72 razy
Wersja publikacji
Accepted albo Published Version
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.3390/ijms24108706
Licencja
Creative Commons: CC-BY otwiera się w nowej karcie

Słowa kluczowe

Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES nr 24,
ISSN: 1661-6596
Język:
angielski
Rok wydania:
2023
Opis bibliograficzny:
Izadi F., Szczyrba A., Datta M., Ciupak O., Demkowicz S., Rak J., Denifl S.: Electron-Induced Decomposition of 5-Bromo-4-thiouracil and 5-Bromo-4-thio-2′-deoxyuridine: The Effect of the Deoxyribose Moiety on Dissociative Electron Attachment// INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES -Vol. 24,iss. 10 (2023), s.8706-
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.3390/ijms24108706
Źródła finansowania:
Weryfikacja:
Politechnika Gdańska

wyświetlono 117 razy

Publikacje, które mogą cię zainteresować

Electron-Induced Decomposition of Uracil-5-yl O-(N,N-dimethylsulfamate): Role of Methylation in Molecular Stability

  • E. Arthur-Baidoo,
  • K. Falkiewicz,
  • L. Chomicz-Mańka
  • + 6 autorów
2021

Intramolecular Proton Transfer in the Radical Anion of Cytidine Monophosphate Sheds Light on the Sensitivities of Dry vs Wet DNA to Electron Attachment-Induced Damage

  • L. Chomicz-Mańka,
  • A. Czaja,
  • K. Falkiewicz
  • + 11 autorów
2023

5-Selenocyanato and 5-trifluoromethanesulfonyl derivatives of 2′-deoxyuridine: synthesis, radiation and computational chemistry as well as cytotoxicity

  • S. Makurat,
  • M. Zdrowowicz,
  • L. Chomicz-Mańka
  • + 6 autorów
2018

Dissociative Electron Attachment to 5-Iodo-4-thio-2′-deoxyuridine: A Potential Radiosensitizer of Hypoxic Cells

  • M. Saqib,
  • E. Arthur-Baidoo,
  • F. Izadi
  • + 5 autorów
2023
Meta Tagi