Gold nanoparticles for cancer radiotherapy: a review - Publikacja - MOST Wiedzy

Wyszukiwarka

Gold nanoparticles for cancer radiotherapy: a review

Abstrakt

Radiotherapy is currently used in around 50% of cancer treatments and relies on the deposition of energy directly into tumour tissue. Although it is generally effective, some of the deposited energy can adversely affect healthy tissue outside the tumour volume, especially in the case of photon radiation (gamma and X-rays). Improved radiotherapy outcomes can be achieved by employing ion beams due to the characteristic energy deposition curve which culminates in a localised, high radiation dose (in form of a Bragg peak). In addition to ion radiotherapy, novel sensitisers, such as nanoparticles, have shown to locally increase the damaging effect of both photon and ion radiation, when both are applied to the tumour area. Amongst the available nanoparticle systems, gold nanoparticles have become particularly popular due to several advantages: biocompatibility, well-established methods for synthesis in a wide range of sizes, and the possibility of coating of their surface with a large number of different molecules to provide partial control of, for example, surface charge or interaction with serum proteins. This gives a full range of options for design parameter combinations, in which the optimal choice is not always clear, partially due to a lack of understanding of many processes that take place upon irradiation of such complicated systems. In this review, we summarise the mechanisms of action of radiation therapy with photons and ions in the presence and absence of nanoparticles, as well as the influence of some of the core and coating design parameters of nanoparticles on their radiosensitisation capabilities.

Cytowania

  • 3 2 9

    CrossRef

  • 0

    Web of Science

  • 3 2 6

    Scopus

Autorzy (9)

  • Zdjęcie użytkownika  Kaspar Haume

    Kaspar Haume

    • The Open University Department of Physical Sciences
  • Zdjęcie użytkownika  Soraia Rosa

    Soraia Rosa

    • Queen’s University Belfast School of Medicine, Dentistry and Biomedical Sciences
  • Zdjęcie użytkownika  Sophie Grellet

    Sophie Grellet

    • The Open University Department of Life, Health and Chemical Sciences
  • Zdjęcie użytkownika  Karl Butterworth

    Karl Butterworth

    • Queen’s University Belfast .
  • Zdjęcie użytkownika  Andrey V. Solov’yov

    Andrey V. Solov’yov

    • MBN Research Center School of Medicine, Dentistry and Biomedical Sciences
  • Zdjęcie użytkownika  Kevin Prise

    Kevin Prise

    • Queen’s University Belfast School of Medicine, Dentistry and Biomedical Sciences
  • Zdjęcie użytkownika  Jon Golding

    Jon Golding

    • The Open University Department of Life, Health and Chemical Sciences
  • Zdjęcie użytkownika  Nigel J. Mason

    Nigel J. Mason

    • The Open University Department of Physical Sciences

Słowa kluczowe

Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
publikacja w in. zagranicznym czasopiśmie naukowym (tylko język obcy)
Opublikowano w:
Cancer Nanotechnology nr 7, strony 1 - 20,
ISSN: 1868-6958
Język:
angielski
Rok wydania:
2016
Opis bibliograficzny:
Haume K., Rosa S., Grellet S., Śmiałek-Telega M., Butterworth K., Solov’yov A., Prise K., Golding J., Mason N.. Gold nanoparticles for cancer radiotherapy: a review. Cancer Nanotechnology, 2016, Vol. 7, , s.1-20
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1186/s12645-016-0021-x
Weryfikacja:
Politechnika Gdańska

wyświetlono 116 razy

Publikacje, które mogą cię zainteresować

Meta Tagi