Stable nanoconjugates of transferrin with alloyed quaternary nanocrystals Ag–In–Zn–S as a biological entity for tumor recognition - Publikacja - MOST Wiedzy

Twoje konto

zaloguj

Wyszukiwarka

Stable nanoconjugates of transferrin with alloyed quaternary nanocrystals Ag–In–Zn–S as a biological entity for tumor recognition

Abstrakt

One way to limit the negative effects of anti-tumor drugs on healthy cells is targeted therapy employing functionalized drug carriers. Here we present a biocompatible and stable nanoconjugate of transferrin anchored to Ag-In-Zn-S quantum dots modified with 11-mercaptoundecanoic acid (Tf-QD) as a drug carrier versus typical anticancer drug, doxorubicin. Detailed investigations of Tf-QD nanoconjugates without and with doxorubicin by fluorescence studies and cytotoxic measurements showed that the biological activity both the transferrin and doxorubicin was fully retained in the nanoconjugate. In particular, the intercalation capabilities of free doxorubicin versus ctDNA remained essentially intact upon its binding to the nanoconjugate. In order to evaluate these capabilities, we studied the binding constant of doxorubicin attached to Tf-QD with ctDNA as well as the binding site size on the ctDNA molecule. The binding constant slightly decreased compared to that of free doxorubicin while the binding site size, describing the number of consecutive DNA lattice residues involved in the binding, increased. It was also demonstrated that QD alone and in the form of nanoconjugate with Tf were not cytotoxic towards human non-small cell lung carcinoma (H460 cell line) and the tumor cell sensitivity of the DOX-Tf-QD nanoconjugate was comparable to that of doxorubicin alone.

Cytowania

  • 1 5

    CrossRef

  • 0

    Web of Science

  • 1 6

    Scopus

Autorzy (7)

Cytuj jako

Pełna treść

pobierz publikację
pobrano 51 razy
Wersja publikacji
Accepted albo Published Version
Licencja
Copyright (Royal Society of Chemistry 2018)

Słowa kluczowe

Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuł w czasopiśmie wyróżnionym w JCR
Opublikowano w:
NANOSCALE nr 10, wydanie 3, strony 1286 - 1296,
ISSN: 2040-3364
Język:
angielski
Rok wydania:
2018
Opis bibliograficzny:
Matysiak-Brynda E., Bujak P., Augustin E., Kowalczyk A., Mazerska Z., Pron A., Nowicka a.: Stable nanoconjugates of transferrin with alloyed quaternary nanocrystals Ag–In–Zn–S as a biological entity for tumor recognition// NANOSCALE. -Vol. 10, iss. 3 (2018), s.1286-1296
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1039/c7nr07819f
Weryfikacja:
Politechnika Gdańska

wyświetlono 149 razy

Publikacje, które mogą cię zainteresować

In vitro biological evaluation of a novel folic acid-targeted receptor quantum dot−β−cyclodextrin carrier for C-2028 unsymmetrical bisacridine in the treatment of human lung and prostate cancers

2024

Improved cytotoxicity and preserved level of cell death induced in colon cancer cells by doxorubicin after its conjugation with iron-oxide magnetic nanoparticles

2016

Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints

2010

Progress in targeting tumor cells by using drug-magnetic nanoparticles conjugate.

  • A. M. Nowicka,
  • A. Kowalczyk,
  • A. Jarzębińska
  • + 5 autorów
2013
Meta Tagi