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The biological role of prolyl oligopeptidase and the procognitive potential of its peptidic inhibitors from food proteins

Abstrakt

Prolyl oligopeptidase (POP) is a conserved serine protease belonging to proline-specific peptidases. It has both enzymatic and non-enzymatic activity and is involved in numerous biological processes in the human body, playing a role in e.g., cellular growth and differentiation, inflammation, as well as the development of some neurodegenerative and neuropsychiatric disorders. This article describes the physiological and pathological aspects of POP activity and the state-of-art of its peptidic inhibitors originating from food proteins, with a particular focus on their potential as cognition-enhancing agents. Although some milk, meat, fish, and plant protein-derived peptides have the potential to be applied as natural, procognitive nutraceuticals, their effectiveness requires further evaluation, especially in clinical trials. We demonstrated that the important features of the most promising POP-inhibiting peptides are very short sequence, high content of hydrophobic amino acids, and usually the presence of proline residue.

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Wersja publikacji
Accepted albo Published Version
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1080/10408398.2023.2170973
Licencja
Creative Commons: CC-BY otwiera się w nowej karcie

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Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuły w czasopismach
Opublikowano w:
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION strony 1 - 14,
ISSN: 1040-8398
Język:
angielski
Rok wydania:
2023
Opis bibliograficzny:
Taraszkiewicz A., Sinkiewicz I., Sommer A., Staroszczyk H.: The biological role of prolyl oligopeptidase and the procognitive potential of its peptidic inhibitors from food proteins// CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION -, (2023), s.1-14
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1080/10408398.2023.2170973
Źródła finansowania:
Weryfikacja:
Politechnika Gdańska

wyświetlono 117 razy

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