Wyszukiwarka
Wyniki wyszukiwania dla: ANDROGEN RECEPTOR
Znaleźliśmy mało wyników, wypróbuj alternatywnej metody wyszukiwania.
Filtry
wszystkich: 7
wybranych: 1
Filtry wybranego katalogu
Wyniki wyszukiwania dla: ANDROGEN RECEPTOR
-
Anticancer Imidazoacridinone C-1311 is Effective in Androgen-Dependent and Androgen-Independent Prostate Cancer Cells
PublikacjaAndrogen receptor (AR) plays a crutial role in prostate cancer (PCa) development and metastasis. Here, we reported potent anti-PCa activity of a small molecule imidazoacridinone C-1311. In AR-positive PCa cells, C-1311 was found to inhibit the transcriptional activity of AR uncovering a novel mechanism that may be relevant for its anticancer effect. Mechanistically, C-1311 decreased AR binding to prostate-specific antigen (PSA)...