Wyniki wyszukiwania dla: expression plasmids

• Human UDP-Glucuronosyltransferases: Effects of altered expression in breast and pancreatic cancer cell lines.

  Publikacja

  • C. Dates
  • T. Fahmi
  • S. Pyrek
  • A. Yao-Borengasser
  • B. Borowa-Mazgaj
  • S. M. Bratton
  • S. Kadlubar
  • P. Mackenzie
  • R. Haun
  • A. Radominska-Pandya

  - CANCER BIOLOGY & THERAPY - Rok 2015

  Increased aerobic glycolysis and de novo lipid biosynthesis are common characteristics of invasive cancers. UDP-glucuronosyltransferases (UGTs) are phase II drug metabolizing enzymes that in normal cells possess the ability to glucuronidate these lipids and speed their excretion; however, de-regulation of these enzymes in cancer cells can lead to an accumulation of bioactive lipids, which further fuels cancer progression. We hypothesize...

  Pełny tekst do pobrania w portalu

• Dissection of σE‐dependent cell lysis in Escherichia coli: roles of RpoE regulators RseA, RseB and periplasmic folding catalyst PpiD

  Publikacja

  • R. Noor
  • M. Murata
  • H. Nagamitsu
  • G. Klein-Raina
  • S. Raina
  • M. Yamada

  - GENES TO CELLS - Rok 2009

  To understand the mechanism of sigma(E)-dependent cell lysis, we examined the consequences of deletion derivatives of rpoE regulators rseA, rseB and rseC on sigma(E) transcription, on levels of free versus membrane-bound sigma(E) and on OMP-biogenesis limiting factor(s) that could impact cell lysis. RT-PCR showed that individual nonpolar DeltarseA and DeltarseB increased the rpoE expression to varying extents, with pronounced induction...

  Pełny tekst do pobrania w portalu