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• Mechanism of Binding of Antifungal Antibiotic Amphotericin B to Lipid Membranes: An Insight from Combined Single-Membrane Imaging, Microspectroscopy, and Molecular Dynamics

  Publikacja

  • E. Grela
  • M. Wieczór
  • R. Luchowski
  • J. Zielinska
  • A. Barzycka
  • W. Grudzinski
  • K. Nowak
  • P. Tarkowski
  • J. Czub
  • W. Gruszecki

  - MOLECULAR PHARMACEUTICS - Rok 2018

  Amphotericin B is a lifesaving polyene antibiotic used in the treatment of systemic mycoses. Unfortunately, the pharmacological applicability of this drug is limited because of its severe toxic side effects. At the same time, the lack of a well-defined mechanism of selectivity hampers the efforts to rationally design safer derivatives. As the drug primarily targets the biomembranes of both fungi and humans, new insights into the...

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