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• Changes in gene methylation patterns in neonatal murine hearts: Implications for the regenerative potential

  Publikacja

  • B. Górnikiewicz
  • A. Ronowicz
  • M. Krzemiński
  • P. Sachadyn

  - BMC GENOMICS - Rok 2016

  Background The neonatal murine heart is able to regenerate after severe injury; this capacity however, quickly diminishes and it is lost within the first week of life. DNA methylation is an epigenetic mechanism which plays a crucial role in development and gene expression regulation. Under investigation here are the changes in DNA methylation and gene expression patterns which accompany the loss of regenerative potential. Results The...

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• Genome-wide DNA methylation profiling of the regenerative MRL/MpJ mouse and two normal strains

  Publikacja

  • B. Górnikiewicz
  • A. Ronowicz
  • P. Madanecki
  • P. Sachadyn

  - EPIGENOMICS-UK - Rok 2017

  Aims We aimed to identify the pivotal differences in the DNA methylation profiles between the regeneration capable MRL/MpJ mouse and reference mouse strains. Materials and Methods Global DNA methylation profiling was performed in ear pinnae, bone marrow, spleen, liver, heart from uninjured adult females of the MRL/MpJ and C57BL/6J and BALB/c. Results and conclusion A number of differentially methylated regions distinguishing between...

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