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• Introduction of Pro and Its Analogues in the Conserved P1 Position of Trypsin Inhibitor SFTI-1 Retains Its Inhibitory Activity

  Publikacja

  • A. Legowska
  • D. Debowski
  • R. Lukajtis
  • E. Sztabkowska
  • A. Mizeria
  • K. Brzozowski
  • M. Wysocka
  • A. Lesner
  • K. Rolka

  - PROTEIN AND PEPTIDE LETTERS - Rok 2011

  A number of monocyclic SFTI-1 analogues modified in the conserved inhibitor P1 position by Pro, its L-hydroxyproline (Hyp) derivative as well as mimetics with different ring size were synthesized by the solid-phase method. Replacement of Ser6 by Pro, Hyp, and a four-member ring, L-azetidine-2-carboxylic acid (Aze), retained trypsin or chymotrypsin inhibitory activity. The determined association equilibrium constants of these analogues...

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