Wyniki wyszukiwania dla: NHBE

• Cytotoxicity of anthraquinone derivatives (Compound 1-9) towards NHBE normal cells

  Dane Badawcze

  open access

  • N. Maciejewska

  This study presents absorbance values of formazan product (converted from MTT) which corresponds to the cytotoxicity of anthraquinone derivatives (Compound 1-9) towards NHBE normal cells.

• Confocal microscopy analysis of DNA DSB in telomerase negative cells after exposure to TXT2 and TXT4

  Dane Badawcze

  open access

  • N. Maciejewska

  The data sets contain confocal microscopic images showing the γ-H2AX with TRF2 after treatment of NHBE and U2OS cell lines with TXT2 and TXT4 in equitoxic concentrations. Images were acquired with an LSM 800 inverted laser scanning confocal microscope (Carl Zeiss; Dresden, Germany) equipped with an Airyscan detector using a ×63 1.4 NA Plan Apochromat...

• Teloxantron inhibits the processivity of telomerase with preferential DNA damage on telomeres

  Publikacja

  • N. Maciejewska
  • M. Olszewski
  • J. Jurasz
  • M. Bagiński
  • S. Maryna
  • Z. Viktor
  • M. Folini
  • N. Zaffaroni

  - Cell Death and Disease - Rok 2022

  Telomerase reactivation is one of the hallmarks of cancer, which plays an important role in cellular immortalization and the development and progression of the tumor. Chemical telomerase inhibitors have been shown to trigger replicative senescence and apoptotic cell death both in vitro and in vivo. Due to its upregulation in various cancers, telomerase is considered a potential target in cancer therapy. In this study, we identified...

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