Wyniki wyszukiwania dla: PHARMACOLOGICAL REGENERATION

• Discovery of small-molecule regenerative drugs using a model of complex tissue injury in mice. Transcriptomic responses of neurodevelopmental genes during pharmacologically induced regeneration

  Publikacja

  • P. Sosnowski

  - Rok 2021

  Despite significant development in regenerative medicine, there is a deficit of effective therapies for wound healing and tissue regeneration. Research performed using animal wound models allows for a better understanding of this complex process, searching for compounds with pro-regenerative properties, and assessing their efficacy and safety. Unfortunately, the lack of adequate preclinical models proves to be an issue as no animal...

• Epigenetic inhibitor zebularine activates ear pinna wound closure in the mouse

  Publikacja

  • P. Sass
  • P. Sosnowski
  • J. Podolak-Popinigis
  • B. Górnikiewicz
  • J. Kamińska
  • M. Deptuła
  • E. Nowicka
  • A. Wardowska
  • J. Ruczyński
  • P. Rekowski... i 12 innych

  - EBioMedicine - Rok 2019

  Background:Most studies on regenerative medicine focus on cell-based therapies and transplantations.Small-molecule therapeutics, though proved effective in different medical conditions, have not been extensivelyinvestigated in regenerative research. It is known that healing potential decreases with development and devel-opmental changes are driven by epigenetic mechanisms, which suggests epigenetic repression of regenerativecapacity.Methods:We...

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