Wyniki wyszukiwania dla: THROMBIN

• Thermodynamic, Anticoagulant, and Antiproliferative Properties of Thrombin Binding Aptamer Containing Novel UNA Derivative

  Publikacja

  • W. Kotkowiak
  • J. Lisowiec-Wachnicka
  • J. Grynda
  • R. Kierzek
  • J. Wengel
  • A. Pasternak

  - Molecular Therapy-Nucleic Acids - Rok 2018

  Thrombin is a serine protease that plays a crucial role in hemostasis, fibrinolysis, cell proliferation, and migration. Thrombin binding aptamer (TBA) is able to inhibit the activity of thrombin molecule via binding to its exosite I. This 15-nt DNA oligonucleotide forms an intramolecular, antiparallel G-quadruplex structure with a chair-like conformation. In this paper, we report on our investigations on the influence of certain...

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• Denser plasma clot formation and impaired fibrinolysis in paroxysmal and persistent atrial fibrillation while on sinus rhythm: Association with thrombin generation, endothelial injury and platelet activation

  Publikacja

  • L. Drabik
  • P. Wołkow
  • A. Undas

  - THROMBOSIS RESEARCH - Rok 2015

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