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• General, Mild, and Metal-Free Functionalization of Indole and Its Derivatives Through Direct C3-Selenylation

  Publikacja

  • A. Hałuszczuk
  • N. Babul
  • Ł. Nierzwicki
  • W. Przychodzeń

  - EUROPEAN JOURNAL OF ORGANIC CHEMISTRY - Rok 2019

  A very mild method for the introduction of functionalized alkylselenyl group at C-3 position of the indole ring was developed. The proposed procedure consists of an electrophilic substitution of indole and its derivatives with bis(O,O-diisopropoxyphosphorothioyl) diselenide and subsequent cleavage of the P–Se bond with tetrabutylammonium fluoride in the presence of various electrophilic reagents. This method can be successfully...

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