Wyniki wyszukiwania dla: EPIGENETIC DRUGS

• Disposition of Drugs of Abuse and Their Metabolites in Wastewater as a Method of the Estimation of Drug Consumption

  Publikacja

  • E. Daghir
  • M. J.

  - Current Drug Metabolism - Rok 2010

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• Methods for Elucidation of DNA-Anticancer Drug Interactions and Their Applications in the Development of New Drugs

  Publikacja

  • M. Misiak
  • F. Mantegazza
  • G. Beretta

  - CURRENT PHARMACEUTICAL DESIGN - Rok 2016

  DNA damaging agents including anthracyclines, camptothecins and platinum drugs are among most frequently used drugs in the chemotherapeutic routine. Due to their relatively low selectivity for cancer cells, administration is associated with adverse side effects, whereas the inherent genotoxicity of these drugs is associated with risk of developing secondary cancers. Development of new drugs, which could be spared of these drawbacks...

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• The role of epigenetics in regeneration

  Publikacja

  • J. Podolak-Popinigis
  • B. Górnikiewicz

  - Rok 2013

  Complex changes in chromatin structure and at the transcriptional level occur from the creation of a single parental gamete throughout fertilization, embryo development and the life of an adult organism. Epigenetic changes, such as methylation and hydroxymethylation of DNA or histone methylation and acetylation, are an important part of these processes. Epigenetic regulation has an essential influence on gene expression level. DNA...

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• Genetic and Epigenetic Aspects of Atopic Dermatitis

  Publikacja

  • B. Nedoszytko
  • E. Reszka
  • D. Gutowska-Owsiak
  • M. Trzeciak
  • M. Lange
  • J. Jarczak
  • M. Niedoszytko
  • E. Jablonska
  • J. Romantowski
  • D. Strapagiel... i 6 innych

  - INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - Rok 2020

  Atopic dermatitis is a heterogeneous disease, in which the pathogenesis is associated with mutations in genes encoding epidermal structural proteins, barrier enzymes, and their inhibitors; the role of genes regulating innate and adaptive immune responses and environmental factors inducing the disease is also noted. Recent studies point to the key role of epigenetic changes in the development of the disease. Epigenetic modifications...

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• Genetics & Epigenetics

  Czasopisma

  ISSN: 1179-237X

• Epigenetics & Chromatin

  Czasopisma

  ISSN: 1756-8935

• EPIGENETICS-US

  Czasopisma

  ISSN: 1559-2294 , eISSN: 1559-2308

• Epigenetics Insights

  Czasopisma

  ISSN: 2516-8657

• Environmental Epigenetics

  Czasopisma

  ISSN: 2058-5888

• Glutathione-mediated conjugation of anticancer drugs: an overview of reaction mechanisms and biological significance for drug detoxification and bioactivation.

  Publikacja

  • A. Potęga

  - MOLECULES - Rok 2022

  The effectiveness of many anticancer drugs depends on the creation of specific metabolites that may alter their therapeutic or toxic properties. One significant route of biotransformation is a conjugation of electrophilic compounds with reduced glutathione, which can be non-enzymatic and/or catalyzed by glutathione-dependent enzymes. Glutathione usually combines with anticancer drugs and/or their metabolites to form more polar...

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