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• Structural Factors Affecting Cytotoxic Activity of (E)-1-(Benzo[d ][1,3]oxathiol-6-yl)-3-phenylprop-2-en-1-one Derivatives

  Publikacja

  • M. T. Konieczny
  • A. Bułakowska
  • J. Polak
  • D. Pirska
  • W. Konieczny
  • P. Gryń
  • A. Składanowski
  • M. Sabisz
  • K. Lemke
  • A. Pieczykolan... i 3 innych

  - Chemical Biology & Drug Design - Rok 2014

  Derivatives of (E)-1-(5-alkoxybenzo[d][1,3]oxathiol-6-yl)-3-phenylprop-2-en-1-one (1) demonstrated exceptionally high in vitro cytotoxic activity, with IC50 values of the most active derivatives in the nanomolar range. To identify structural fragments necessary for the activity, several analogs deprived of selected fragments were prepared, and their cytotoxic activity was tested. It was found that the activity depends on combined effects...

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