Wyniki wyszukiwania dla: UMBRELLAS

• Molecular Umbrella as A Nanocarrier for Antifungals

  Publikacja

  • A. S. Skwarecki
  • D. Martynow
  • M. J. Milewska
  • S. Milewski

  - MOLECULES - Rok 2021

  A molecular umbrella composed of two O‐sulfated cholic acid residues was applied for the construction of conjugates with cispentacin, containing a “trimethyl lock” (TML) or o‐dithiobenzylcarbamoyl moiety as a cleavable linker. Three out of five conjugates demonstrated antifungal in vitro activity against C. albicans and C. glabrata but not against C. krusei, with MIC90 values in the 0.22–0.99 mM range and were not hemolytic. Antifungal...

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• Molecular Umbrellas Modulate the Selective Toxicity of Polyene Macrolide Antifungals

  Publikacja

  • A. S. Skwarecki
  • K. Skarbek
  • D. Martynow
  • M. Serocki
  • I. Bylińska
  • M. J. Milewska
  • S. Milewski

  - BIOCONJUGATE CHEMISTRY - Rok 2018

  Antifungal polyene macrolide antibiotics Amphotericin B (AmB) and Nystatin (NYS) were conjugated through the ω-amino acid linkers with diwalled “molecular umbrellas” composed of spermidine-linked deoxycholic or cholic acids. The presence of “umbrella” substituents modulated biological properties of the antibiotics, especially their selective toxicity. Some of the AmB-umbrella conjugates demonstrated antifungal in vitro activity...

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• Analytical data on molecular umbrella: cispentacin and molecular umbrella: fluorescent probe conjugates

  Dane Badawcze

  open access

  • S. Milewski
  • A. Skwarecki
  • M. Milewska

  Analytical data (NMR, MS, FTIR) for nine conjugates of molecular umbrella with cispentacin, Lys(Mca) or Nap-NH2. The conjugates have been rationally designed as potential antifungal agents. 1H NMR and 13C NMR spectra were obtained at 500 MHz Varian Unity Plus spectrometer and the deuterated solvents were used as internal locks. High-resolution mass...

• Piotr Lorens prof. dr hab. inż. arch.

  Osoby

  Katedra Urbanistyki i Planowania Regionalnego

  Piotr Lorens – prof. dr hab. inż. arch., prof. nzw. Politechniki Gdańskiej. Po ukończeniu studiów w 1994 roku podjął pracę w Zakładzie Rozwoju Miasta na Wydziale Architektury Politechniki Gdańskiej. Uzyskawszy Stypendium Fulbrighta wyjechał na staż do USA, gdzie w latach 1996-1997 ukończył Special Program for Urban and Regional Studies na Massachusetts Institute of Technology oraz International Training Program na Harvard University...

• New Materiality-towards ‘Media Environments

  Publikacja

  • K. Życzkowska
  • B. Konarzewska

  - Procedia Engineering - Rok 2016

  Article presents media solutions providing new materiality of architectural spaces. Media solutions in architecture evolve in new forms. Articlepresentsboth the developmentof new technological solutionsas well as new ways of application of media solutions in relation toarchitectural form. The aim of the article is to show technical aspects of new materiality - intelligent materials, allowing transmission of changeable visual content...

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• Antimicrobial molecular nanocarrier–drug conjugates

  Publikacja

  • A. S. Skwarecki
  • S. Milewski
  • M. Schielmann
  • M. J. Milewska

  - Nanomedicine-Nanotechnology Biology and Medicine - Rok 2016

  Many antimicrobial drugs are poorly active against pathogenic microbes causing intracellular infections, such as Mycobacterium tuberculosis or Plasmodium falciparum. On the other hand, several known antimicrobial agents are not effective enough because of their limited cellular penetration. A common feature of both challenges is the inability of an active agent to cross the biological membrane(s). One of the possible approaches...

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• Synthetic strategies in construction of organic low molecular-weight carrier-drug conjugates

  Publikacja

  • A. S. Skwarecki
  • M. Nowak
  • M. J. Milewska

  - BIOORGANIC CHEMISTRY - Rok 2020

  Inefficient transportation of polar metabolic inhibitors through cell membranes of eukaryotic and prokaryotic cells precludes their direct use as drug candidates in chemotherapy. One of the possible solutions to this problem is application of the ‘Trojan horse’ strategy, i.e. conjugation of an active substance with a molecular carrier of organic or inorganic nature, facilitating membrane penetration. In this work, the synthetic...

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• Are Pair Trading Strategies Profitable During COVID-19 Period?

  Publikacja

  • M. K. Sohail
  • A. Raheman
  • J. Iqbal
  • M. I. Sindhu
  • A. Staar
  • M. Mushafiq
  • H. Afzal

  - Journal of Information & Knowledge Management - Rok 2022

  Pair trading strategy is a well-known profitable strategy in stock, forex, and commodity markets. As most of the world stock markets declined during COVID-19 period, therefore this study is going to observe whether this strategy is still profitable after COVID-19 pandemic. One of the powerful algorithms of DBSCAN under the umbrella of unsupervised machine learning is applied and three clusters were formed by using market and accounting...

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• Health Enhancing Physical Activity Policies in Poland: Findings from the HEPA PAT Survey

  Publikacja

  • A. Romanowska
  • A. Morawiak
  • C. Woods
  • L. Kelly
  • K. Volf
  • P. Gelius
  • S. Messing
  • S. Forberger
  • J. Lakerveld
  • N. R. Den Braver... i 2 innych

  - International Journal of Environmental Research and Public Health - Rok 2022

  Insufficient physical activity (PA) is one of major risk factors for serious diseases and premature mortality worldwide. Public policies to enhance PA across society are recognized as an effective tool against the problem. This paper presents the results of a comprehensive assessment of national-level PA policy approach in Poland. A standardized survey of Word Health Organization named the Health-Enhancing Physical Activity Policy...

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• Wilms tumor - Female, 4 - Tissue image [507073002620391]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [5070730026203541]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [5070730026207701]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [5070730026206891]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [507073002620741]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [5070730026207791]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [704024710495971]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [5070730026203471]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [5070730026201021]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [507073002620791]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [5070730026204941]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [5070730026203821]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [5070730026209831]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [5070730026209161]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [5070730026204341]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [5070730026204961]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [5070730026203061]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [5070730026201131]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [5070730026208671]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [5070730026205781]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [5070730026206171]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [5070730026204501]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [5070730026204841]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [5070730026206121]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [5070730026206691]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [5070730026204811]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [5070730026207141]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Wilms tumor - Female, 4 - Tissue image [5070730026201971]

  Dane Badawcze

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Spectroscopic studies on physicochemical properties of selected unsymmetrical bisacridine derivatives and NMR analysis of their interactions with the model sequence Pu22 aided by molecular dynamics

  Publikacja

  • M. Kosno

  - Rok 2024

  In recent years, new promising acridine derivatives have appeared, belonging to the unsymmetrical bisacridines (UAs) family with high anticancer activity. Both their physicochemical properties and their mechanism of action at the molecular level have not been thoroughly analyzed so far. Four derivatives were selected for the study, termed as: C-2028, C-2041, C-2045 and C-2053. The first aim of this work was to determine the protonation...

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• Magdalena Szuflita-Żurawska

  Osoby

  Politechnika Gdańska, Sekcja Informacji Naukowo-Technicznej, Biblioteka PG

  Magdalena Szuflita-Żurawska jest kierownikiem Sekcji Informacji Naukowo-Technicznej na Politechnice Gdańskiej oraz Liderem Centrum Kompetencji Otwartej Nauki przy Bibliotece Politechniki Gdańskiej. Jej główne zainteresowania badawcze koncentrują się w obszarze komunikacji naukowej oraz otwartych danych badawczych, a także motywacji i produktywności naukowej. Jest odpowiedzialna między innymi za prowadzenie szkoleń dla pracowników...