Year 2017

• Daily diet containing canned products significantly increases serum concentrations of endocrine disruptor bisphenol A in young women

  Publication

  • A. Szybiak
  • A. Rutkowska
  • K. Wilczewska
  • A. Wasik
  • J. Namieśnik
  • D. Rachoń

  - Polish Archives of Internal Medicine - Year 2017

  Nowadays, exposure to environmental factors is considered to be one of the possible causes of several lifestyle diseases, such as obesity, type 2 diabetes, cardiovascular disease, and cancer. Particularly noteworthy are endocrine‑disrupting chemicals (EDCs), which affect the metabolism of hormones and interact with their receptors, thus exerting adverse health effects. One of the most ubiquitous EDC in daily life is bisphenol A...

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• Identification of novel psychoactive substances 25B-NBOMe and 4-CMC in biological material using HPLC-Q-TOF-MS and their quantification in blood using UPLC–MS/MS in case of severe intoxications

  Publication

  • M. Wiergowski
  • J. Aszyk
  • M. Kaliszan
  • K. Wilczewska
  • J. Sein Anand
  • A. Kot-Wasik
  • Z. Jankowski

  - JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES - Year 2017

  This paper describes cases of poisoning caused by new psychoactive substances such as: 25BNBOMe (2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine) and 4-CMC (1-(4-chlorophenyl)-2-(methylamino)-1-propanone). The analytical procedure includes rapid and selective method for the extraction and determination of 4-CMC and 25B-NBOMe in blood samples using UPLC–MS/MS technique. To the best of our knowledge,this is...

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Year 2016

• Troubleshooting of the determination of bisphenol A at ultra-trace levels by liquid chromatography and tandem mass spectrometry

  Publication

  • K. Wilczewska
  • J. Namieśnik
  • A. Wasik

  - ANALYTICAL AND BIOANALYTICAL CHEMISTRY - Year 2016

  Determination of trace amounts of bisphenol A (BPA) may cause problems mainly related to the presence of BPA in solvents (even in LC-MS grade), laboratory vessels, and plastic equipment used for sample preparation. Variable and sometimes significant amounts of BPA present in the background cause problems in obtaining good repeatability of measurements at the ultra-trace levels. Such observations (i.e., poor repeatability of results)...

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Year 2014

• Czy wiemy co łykamy? – Zanieczyszczenia w produktach farmaceutycznych i sposoby ich detekcji

  Publication

  • K. Wilczewska
  • A. Kot-Wasik
  • J. Namieśnik

  - Analityka: Nauka i Praktyka - Year 2014

  W skład produktów farmaceutycznych, obok substancji farmakologicznie czynnych wchodzą również różnego typu substancje pomocnicze. Istnieje niebezpieczeństwo, że w preparatach farmaceutycznych obecne są także zanieczyszczenia i produkty degradacji, które mogą negatywnie wpływać na skuteczność stosowanych leków, a jednocześnie stanowić zagrożenie dla zdrowia i życia człowieka. Z tego względu niezbędny jest monitoring składu produktów...

• Czy wiemy, co łykamy? Zanieczyszczenia obecne w produktach farmaceutycznych i sposoby ich detekcji

  Publication

  • K. Wilczewska
  • A. Kot-Wasik
  • J. Namieśnik

  - Analityka: Nauka i Praktyka - Year 2014

  Wykrycie oraz identyfikacja i ilościowe oznaczanie zanieczyszczeń obecnych w produktach farmacetycznych jest bezwzglednie konieczne, aby uchronić pacjenta przed nieprawidlowym dzialaniem i skutkami ubocznymi, które mogą wystąpić po spozyciu zanieczyszczonego leku. Z tego względu monitoring skladu produktów farmaceutycznych jest niezbędny.

• The potential role of bisphenol A in the pathogenesis of polycystic ovary syndrome

  Publication

  • A. Rutkowska
  • K. Wilczewska
  • Ł. Laczmański
  • J. Kuliczkowska
  • A. Lenarcik
  • A. Trzmiel-Bira
  • A. Brona
  • M. Kuligowska-Jakubowska
  • A. Konieczna
  • A. Kot-Wasik... and 4 others

  - Endocrine Abstracts - Year 2014

  Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, that lead to infertility, type 2 diabetes and coronary heart disease. Bisphenol A (BPA) is one of the most abundant chemicals produced worldwide and is used as a plasticizer in daily life. Nowadays it is also well know that it can interact with estrogen receptors, androgen receptors and peroxisome proliferatoractivated receptors g (PPARg)....

Year 2013

• LC-MS and LC-NMR as Complementary Techniques for the Determination of Pharmaceuticals in Dosage Formulations

  Publication

  • K. Wilczewska
  • A. Kot-Wasik
  • J. Namieśnik

  - CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY - Year 2013

  Pharmaceuticals contain not only pharmacologically active compounds but also a range of excipients. The danger exists that impurities may also be present in such drugs, which may adversely affect their efficacy and even endanger patient health and life. Monitoring the composition of pharmaceutical products is therefore essential. The trace amounts of such impurities in pharmaceuticals are often identified and determined with liquid...

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Year 2012

• Determination of impurities in pharmaceutical products using LC-MS

  Publication

  • K. Wilczewska

  - Year 2012

  Pharmaceutical products can be contaminated by residues of solvents, reagents (used for the synthesis) or degradation products. Impurities in drug may pose a risk to human health and life, therefore analysis and identification of impurities in pharmaceutical products is veryimportant and inevitable.High performance liquid chromatography coupled with mass spectrometry (MS) is very useful technique for identification impurities in...