Identification of novel psychoactive substances 25B-NBOMe and 4-CMC in biological material using HPLC-Q-TOF-MS and their quantification in blood using UPLC–MS/MS in case of severe intoxications - Publication - Bridge of Knowledge

Your account

login

Search

Identification of novel psychoactive substances 25B-NBOMe and 4-CMC in biological material using HPLC-Q-TOF-MS and their quantification in blood using UPLC–MS/MS in case of severe intoxications

Abstract

This paper describes cases of poisoning caused by new psychoactive substances such as: 25BNBOMe (2-(4-bromo-2,5-dimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine) and 4-CMC (1-(4-chlorophenyl)-2-(methylamino)-1-propanone). The analytical procedure includes rapid and selective method for the extraction and determination of 4-CMC and 25B-NBOMe in blood samples using UPLC–MS/MS technique. To the best of our knowledge,this is thefirst report,thatinvolves a fully validated method for quantification of new-designer drug – 4-CMC in postmortem blood samples. The biological material was also analyzed with the use of routine analytical methods: immunochemical techniques, gas chromatography with flame ionization detection and gas chromatography with electron impact mass spectrometry. The results of real samples analyses correspond to possible toxicological effects: death resulting from 25B-NBOMe - mediated hallucinations (661 ng/mL of 25B-NBOMe and 0.887 ng/mL of 4- CMC), fatal overdose of 25B-NBOMe and 4-CMC (66.5 ng/mL of 25B-NBOMe and 2.14 ng/mL of 4-CMC) and non-fatal intoxication of these drugs (38.4 ng/mL of 25B NBOMe and 0.181 ng/mL of 4-CMC). Additionally, O-demethylathed O, O-bis-demethylathed and glucuronidated metabolites of 25B-NBOMe in biological specimens were detected.

Citations

  • 3 2

    CrossRef

  • 0

    Web of Science

  • 4 0

    Scopus

Authors (7)

Cite as

Full text

full text is not available in portal

Keywords

Details

Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES no. 1041-1042, pages 1 - 10,
ISSN: 1570-0232
Language:
English
Publication year:
2017
Bibliographic description:
Wiergowski M., Aszyk J., Kaliszan M., Wilczewska K., Sein Anand J., Kot-Wasik A., Jankowski Z.: Identification of novel psychoactive substances 25B-NBOMe and 4-CMC in biological material using HPLC-Q-TOF-MS and their quantification in blood using UPLC–MS/MS in case of severe intoxications// JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES. -Vol. 1041-1042, (2017), s.1-10
DOI:
Digital Object Identifier (open in new tab) 10.1016/j.jchromb.2016.12.018
Verified by:
Gdańsk University of Technology

seen 231 times

Recommended for you

Development and validation of a GC–MS/MS method for the determination of 11 amphetamines and 34 synthetic cathinones in whole blood

2020

Comparison of Two Methods for the Determination of Selected Pesticides in Honey and Honeybee Samples

2018

Blood concentrations of a new psychoactive substance 4-chloromethcathinone (4-CMC) determined in 15 forensic cases

2018

The Current State-of-the-Art in the Determination of Pharmaceutical Residues in Environmental Matrices Using Hyphenated Techniques

2014
Meta Tags