A review: Fabrication of porous polyurethane scaffolds

Helena Janik; Michalina Mallach

doi:10.1016/j.msec.2014.12.037

A review: Fabrication of porous polyurethane scaffolds

Abstract

The aim of tissue engineering is the fabrication of three-dimensional scaffolds that can be used for the reconstruction and regeneration of damaged or deformed tissues and organs. A wide variety of techniques have been developed to create either fibrous or porous scaffolds from polymers, metals, composite materials and ceramics. However, the most promising materials are biodegradable polymers due to their comprehensive mechanical properties, ability to control the rate of degradation and similarities to natural tissue structures. Polyurethanes (PUs) are attractive candidates for scaffold fabrication, since they are biocompatible, and have excellent mechanica properties and mechanical flexibility. PU can be applied to various methods of porous scaffold fabrication, among which are solvent casting/particulate leaching, thermally induced phase separation, gas foaming, emulsion freeze-drying and melt moulding. Scaffold properties obtained by these techniques, including pore size, interconnectivity and total porosity, all depend on the thermal processing parameters, and the porogen agent and solvents used. In this review, various polyurethane systems for scaffolds are discussed, aswell as methods of fabrication, including the latest developments, and their advantages and disadvantages.

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Category:: Articles
Type:: artykuł w czasopiśmie wyróżnionym w JCR
Published in:: Materials Science & Engineering C-Materials for Biological Applications no. 48, pages 586 - 591,
ISSN: 0928-4931
Language:: English
Publication year:: 2015
Bibliographic description:: Janik H., Marzec M.: A review: Fabrication of porous polyurethane scaffolds// Materials Science & Engineering C-Materials for Biological Applications. -Vol. 48, (2015), s.586-591
DOI:: Digital Object Identifier (open in new tab) 10.1016/j.msec.2014.12.037
Verified by:: Gdańsk University of Technology