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Abstract
Drug interactions are often desirable particularly in medicine, when treatment of a patient requires using a mixture of drugs in specific doses to produce the adequate therapeutic effect. Unfortunately, interactions between drugs in the environment are not as desirable, despite the fact that drugs are present in the environment at low concentration levels [1]. Pharmaceuticals are present in the environment in a mixture of compounds, which are not inert towards each other, may contribute to the increase (phenomenon of synergism) or decrease (phenomenon of antagonism) of overall toxicity [2]. Pharmaceuticals namely: diclofenac (sodium salt), oxyteracycline hydrochloride, fluoxetine hydrochloride and chloramphenicol, were mixed with each other at different ratios of EC50 and tested using MICROTOX®. Results obtained show the highest toxicity exhibited by mixtures containing diclofenac.
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- Category:
- Conference activity
- Type:
- publikacja w wydawnictwie zbiorowym recenzowanym (także w materiałach konferencyjnych)
- Title of issue:
- Proceedings of the 11th International Students Conference :‘Modern Analytical Chemistry’. strony 213 - 218
- Language:
- English
- Publication year:
- 2015
- Bibliographic description:
- Wieczerzak M., Kudłak B., Namieśnik J.: Application of bioassays in studies on the impact of pharmaceuticals on the environment// Proceedings of the 11th International Students Conference :‘Modern Analytical Chemistry’./ ed. Karel Nesmerak Praga : Charles University in Prague, Faculty of Science, 2015, 2015, s.213-218
- Verified by:
- Gdańsk University of Technology
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