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Abstract
Two nanometre gold nanoparticles (AuNPs), bearing sugar moieties and/or thiol-polyethylene glycol-amine (PEG-amine), were synthesised and evaluated for their in vitro toxicity and ability to radiosensitise cells with 220 kV and 6 MV X-rays, using four cell lines representing normal and cancerous skin and breast tissues. Acute 3 h exposure of cells to AuNPs, bearing PEG-amine only or a 50:50 ratio of alpha-galactose derivative and PEG-amine resulted in selective uptake and toxicity towards cancer cells at unprecedentedly low nanomolar concentrations. Chemotoxicity was prevented by co-administration of N-acetyl cysteine antioxidant, or partially prevented by the caspase inhibitor Z-VAD-FMK. In addition to their intrinsic cancer-selective chemotoxicity, these AuNPs acted as radiosensitisers in combination with 220 kV or 6 MV X-rays. The ability of AuNPs bearing simple ligands to act as cancer-selective chemoradiosensitisers at low concentrations is a novel discovery that holds great promise in developing low-cost cancer nanotherapeutics.
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Authors (11)
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Sophie Grellet
- The Open University School of Life, Health & Chemical Sciences
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Konstantina Tzelepi
- The Open University School of Life, Health & Chemical Sciences
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Meike Roskamp
- Midatech Pharma
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Phil Williams
- Midatech Pharma
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Aquila Sharif
- GenesisCare, Milton Keynes Medical Centre
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Richard Slade-Carter
- GenesisCare, Milton Keynes Medical Centre
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Peter Goldie
- Northampton General Hospital NHS Trust, Radiotherapy Department,
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Nicky Whilde
- Northampton General Hospital NHS Trust, Radiotherapy Department,
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Nigel J. Mason
- The Open University School of Physical Sciences
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Jon Golding
- The Open University School of Life, Health & Chemical Sciences
Cite as
Full text
- Publication version
- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1371/journal.pone.0181103
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- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
PLOS ONE
no. 12,
edition 7,
pages 1 - 21,
ISSN: 1932-6203 - Language:
- English
- Publication year:
- 2017
- Bibliographic description:
- Grellet S., Tzelepi K., Roskamp M., Williams P., Sharif A., Slade-Carter R., Goldie P., Whilde N., Śmiałek-Telega M., Mason N., Golding J.: Cancer-selective, single agent chemoradiosensitising gold nanoparticles// PLOS ONE. -Vol. 12, iss. 7 (2017), s.1-21
- DOI:
- Digital Object Identifier (open in new tab) 10.1371/journal.pone.0181103
- Verified by:
- Gdańsk University of Technology
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