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Cancer-selective, single agent chemoradiosensitising gold nanoparticles

Abstract

Two nanometre gold nanoparticles (AuNPs), bearing sugar moieties and/or thiol-polyethylene glycol-amine (PEG-amine), were synthesised and evaluated for their in vitro toxicity and ability to radiosensitise cells with 220 kV and 6 MV X-rays, using four cell lines representing normal and cancerous skin and breast tissues. Acute 3 h exposure of cells to AuNPs, bearing PEG-amine only or a 50:50 ratio of alpha-galactose derivative and PEG-amine resulted in selective uptake and toxicity towards cancer cells at unprecedentedly low nanomolar concentrations. Chemotoxicity was prevented by co-administration of N-acetyl cysteine antioxidant, or partially prevented by the caspase inhibitor Z-VAD-FMK. In addition to their intrinsic cancer-selective chemotoxicity, these AuNPs acted as radiosensitisers in combination with 220 kV or 6 MV X-rays. The ability of AuNPs bearing simple ligands to act as cancer-selective chemoradiosensitisers at low concentrations is a novel discovery that holds great promise in developing low-cost cancer nanotherapeutics.

Citations

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Authors (11)

  • Photo of  Sophie Grellet

    Sophie Grellet

    • The Open University School of Life, Health & Chemical Sciences
  • Photo of  Konstantina Tzelepi

    Konstantina Tzelepi

    • The Open University School of Life, Health & Chemical Sciences
  • Photo of  Meike Roskamp

    Meike Roskamp

    • Midatech Pharma
  • Photo of  Phil Williams

    Phil Williams

    • Midatech Pharma
  • Photo of  Aquila Sharif

    Aquila Sharif

    • GenesisCare, Milton Keynes Medical Centre
  • Photo of  Richard Slade-Carter

    Richard Slade-Carter

    • GenesisCare, Milton Keynes Medical Centre
  • Photo of  Peter Goldie

    Peter Goldie

    • Northampton General Hospital NHS Trust, Radiotherapy Department,
  • Photo of  Nicky Whilde

    Nicky Whilde

    • Northampton General Hospital NHS Trust, Radiotherapy Department,
  • Photo of  Nigel J. Mason

    Nigel J. Mason

    • The Open University School of Physical Sciences
  • Photo of  Jon Golding

    Jon Golding

    • The Open University School of Life, Health & Chemical Sciences

Keywords

Details

Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
PLOS ONE no. 12, edition 7, pages 1 - 21,
ISSN: 1932-6203
Language:
English
Publication year:
2017
Bibliographic description:
Grellet S., Tzelepi K., Roskamp M., Williams P., Sharif A., Slade-Carter R., Goldie P., Whilde N., Śmiałek-Telega M., Mason N., Golding J.: Cancer-selective, single agent chemoradiosensitising gold nanoparticles// PLOS ONE. -Vol. 12, iss. 7 (2017), s.1-21
DOI:
Digital Object Identifier (open in new tab) 10.1371/journal.pone.0181103
Verified by:
Gdańsk University of Technology

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