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Determination of cyanide in urine and saliva samples by ion chromatography with pulsed amperometric detection
Abstract
Commonly known as a highly toxic chemical, cyanide is also an essential reagent for many industrial processes. It naturally occurs in plant seeds as a cyanogenic glycosides. Another relatively common mode of cyanide exposure is inhalation of environmental tobacco smoke. This study concerns importance to determine cyanide ion in human biological samples. Urine and saliva samples were collected healthy volunteers exposed to tobacco smoke (active smokers) and environmental tobacco smoke (passive smokers). Chromatographic separation was achieved with an anion-exchange column and separated ions were detected by a pulsed amperometric detector. The method produced linear response in a specific concentration range of cyanide ion. The limit of detection was estimated at 0.1 µg/dm3 and 0.5 µg/dm3 for urine and saliva samples, respectively. Cyanide ion concentrations in samples ranged from not detected (below LOD) to 12.88 µg/dm3. The comparison of results of biological samples analyses show an increasing trend in cyanide concentration that may suggest that environmental tobacco might have an impact on human health.
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Authors (4)
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Sylwia Narkowicz dr inż.
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- Accepted or Published Version
- DOI:
- Digital Object Identifier (open in new tab) 10.1007/s00706-017-1977-x
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- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
MONATSHEFTE FUR CHEMIE
no. 148,
edition 9,
pages 1645 - 1649,
ISSN: 0026-9247 - Language:
- English
- Publication year:
- 2017
- Bibliographic description:
- Jaszczak E., Narkowicz, S., Namieśnik J., Polkowska Ż.: Determination of cyanide in urine and saliva samples by ion chromatography with pulsed amperometric detection// MONATSHEFTE FUR CHEMIE. -Vol. 148, iss. 9 (2017), s.1645-1649
- DOI:
- Digital Object Identifier (open in new tab) 10.1007/s00706-017-1977-x
- Verified by:
- Gdańsk University of Technology
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