Determination of pharmaceuticals in fish: method optimization and occurrence in different species from Mediterranean rivers

Belinda Huerta; Anna Jakimska-Nagórska; Meritxell Gros; Sara Rodriguez-Mozaz; Damia Barcelo

Determination of pharmaceuticals in fish: method optimization and occurrence in different species from Mediterranean rivers

Abstract

The multi-residue analytical method developed, based on accelerated solvent extraction, gel permeation chromatography purification and UPLC-MS/MS analysis allowed the simultaneous determination of 21 pharmaceuticals. Recoveries obtained for most of the target compounds were higher than 50%. The application of UPLC-MS/MS operating in the MRM mode, with two transitions monitored for each compound, provided good sensitivity and selectivity. The method presented detection limits in the low ng/g range for the three fish species, thus providing a reliable and robust tool that can be used for routine analysis of multi-class pharmaceuticals in fish tissues. Anti-inflammatories, psychiatric drugs and β-blockers were found in fish samples from the most polluted sites of Mediterranean rivers in the range of 0.6-15 ng/g.

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Category:: Conference activity
Type:: publikacja w wydawnictwie zbiorowym recenzowanym (także w materiałach konferencyjnych)
Title of issue:: 8th Annual LC/MS/MS Workshop on Environmental Applications and Food Safety, Barcelona, Spain, 2-4 July 2012 strony 58 - 62
Language:: English
Publication year:: 2012
Bibliographic description:: Huerta B., Jakimska A., Gros M., Rodriguez-Mozaz S., Barcelo D.: Determination of pharmaceuticals in fish: method optimization and occurrence in different species from Mediterranean rivers// 8th Annual LC/MS/MS Workshop on Environmental Applications and Food Safety, Barcelona, Spain, 2-4 July 2012/ Spain: , 2012, s.58-62
Verified by:: Gdańsk University of Technology