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Development of potential candidate reference materials for drugs in bottom sediment, cod and herring tissues
Abstract
Regular use of a reference material and participation in a proficiency testing program can improve the reliability of analytical data. This paper presents the preparation of candidate reference materials for the drugs metoprolol, propranolol, carbamazepine, naproxen, and acenocoumarol in freshwater bottom sediment and cod and herring tissues. These reference materials are not available commercially. Drugs (between 7 ng/g and 32 ng/g) were added to the samples, and the spiked samples were freezedried, pulverized, sieved, homogenized, bottled, and sterilized by g-irradiation to prepare the candidate materials. Procedures for extraction and liquid chromatography coupled with tandem mass spectrometry were developed to determine the drugs of interest in the studied material. Each target drug was quantified using two analytical procedures, and the results obtained from these two procedures were in good agreement with each other. Stability and homogeneity assessments were performed, and the relative uncertainties due to instability (for an expiration date of 12 months) and inhomogeneity were 10 e25% and 4.0e6.8%, respectively. These procedures will be useful in the future production of reference materials.
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Authors (12)
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Irena Baranowska Prof. dr hab.
- Silesian University of Technology
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Bogusław Buszewski
- Nicolaus Copernicus University Faculty of Chemistry
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Sylwia Magiera
- Silesian University of Technology Department of Inorganic, Analytical Chemistry and Electrochemistry
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Halina Polkowska-Motrenko
- Institute of Nuclear Chemistry and Technology Warsaw
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Paweł Kościelniak
- Jagiellonian University Faculty of Chemistry
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Aneta Woźniakiewicz
- Jagiellonian University Faculty of Chemistry
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Zbigniew Samczyński
- Institute of Nuclear Chemistry and Technology Warsaw
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Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
CHEMOSPHERE
no. 169,
pages 181 - 187,
ISSN: 0045-6535 - Language:
- English
- Publication year:
- 2017
- Bibliographic description:
- Baranowska, I., Buszewski B., Namieśnik J., Konieczka P., Magiera S., Polkowska-Motrenko H., Kościelniak P., Gadzała-Kopciuch R., Woźniakiewicz A., Samczyński Z., Kochańska K., Rutkowska M.: Development of potential candidate reference materials for drugs in bottom sediment, cod and herring tissues// CHEMOSPHERE. -Vol. 169, (2017), s.181-187
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.chemosphere.2016.11.062
- Verified by:
- Gdańsk University of Technology
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