Elimination of excretion of ibuprofen and its metabolites in horses - Publication - Bridge of Knowledge

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Elimination of excretion of ibuprofen and its metabolites in horses

Abstract

Analytical procedure based on application of gas chromatography-mass spectrometry (GC-MS) at the step of detection, identification and quantitation of ibuprofen (IBU) and detection of its metabolites – 1-hydroxyibuprofen (1-OH IBU) and carboxyibuprofen (CBX IBU) in horse urine by selected ion monitoring mode after sample preparation covering extraction at pH 3-4 and methylation has been used. The ions at m/z 161, 220 (methylated ibuprofen), 178, 119 (methylated 1-hydroxyibuprofen) and 145, 264 (methylated carboxyibuprofen) was monitored to indicate the presence of investigated compounds in horse urine. The method was successfully applied to urine samples taken from two horses H1 and H2 that had been given a single oral dose of 0.9 and 1.1 mg/kg of ibuprofen respectively. The results of excretion of ibuprofen and its metabolites were reported.

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Category:
Conference activity
Type:
publikacja w wydawnictwie zbiorowym recenzowanym (także w materiałach konferencyjnych)
Title of issue:
Proceedings of the 11th International Students Conference Modern Analytical Chemistry strony 206 - 212
Language:
English
Publication year:
2015
Bibliographic description:
Waraksa E., Wójtowicz M., Kwiatkowska D., Namieśnik J.: Elimination of excretion of ibuprofen and its metabolites in horses// Proceedings of the 11th International Students Conference Modern Analytical Chemistry/ Praga: Charles Universitety in Prague, 2015, s.206-212
Verified by:
Gdańsk University of Technology

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