Investigation of an elutable N-propylphosphonic acid chitosan derivative composition with a chitosan matrix prepared from carbonic acid solution - Publication - Bridge of Knowledge

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Investigation of an elutable N-propylphosphonic acid chitosan derivative composition with a chitosan matrix prepared from carbonic acid solution

Abstract

Porous chitosan composites using CO2 dissolution procedure and including water soluble N-propylphosphonic chitosan derivative (p-CHI) were obtained and characterized. In contrast to the control material, composites containing modified chitosan distinguished by a rapid moisture absorption and good adhesion to the skin. The FTIR analysis confirmed the presence of propylphosphonic group in the structure of the polymer. The porosity of the materials was in the range 55–77% and decreased with increasong amount of modified chitosan in materials. Solubility of composites was dependent on the content of p-CHI in scaffolds (40%, 25% and 15%) and reached values 11%, 9% and 6,5%, respectively. The values of other parameters like swelling degree (30 g/g) good antioxidant and antimicrobial properties (almost 100% reduction of S.aureus, E.coli and C. albicans growth) and low in vitro cytotoxicity against fibroblasts were highly advantageous for possible biomedical applications of the composites.

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Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
CARBOHYDRATE POLYMERS no. 179, pages 196 - 206,
ISSN: 0144-8617
Language:
English
Publication year:
2018
Bibliographic description:
Mania S., Tylingo R., Augustin E., Gucwa K. M., Szwacki J., Staroszczyk H.: Investigation of an elutable N-propylphosphonic acid chitosan derivative composition with a chitosan matrix prepared from carbonic acid solution// CARBOHYDRATE POLYMERS. -Vol. 179, (2018), s.196-206
DOI:
Digital Object Identifier (open in new tab) 10.1016/j.carbpol.2017.09.082
Verified by:
Gdańsk University of Technology

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