Ion Chromatography with Pulsed Amperometric Detection for Determining Cyanide in Urine and Meconium Samples

Ewa Jaszczak-Wilke; Krystyna Kozioł; Bogumiła Kiełbratowska; Żaneta Polkowska

doi:10.3390/molecules26154672

Ion Chromatography with Pulsed Amperometric Detection for Determining Cyanide in Urine and Meconium Samples

Abstract

The parents’ addictions and eating habits have a significant influence on the child’s growth. The first stool of a newborn baby provides a large amount of information about xenobiotics transmitted by the mother’s body. The analytical technique used in the study is ion chromatography with pulsed amperometric detection (IC-PAD). The biological samples, which were obtained from women staying in a maternity ward and their partners, revealed cyanide concentrations in urine samples spanning 1.30–25.3 g L1. Meanwhile, the results of the meconium samples were in the range of 1.54 g L1 to 24.9 g L1. Under the optimized chromatographic conditions, the IC-PAD system exhibited satisfactory repeatability (R < 3%, n = 3) and good linearity in the range of 1–100 g L1. Thus, it proved to be an effective tool for monitoring trace cyanide concentration in a series of human body fluid matrices, including meconium. Based on the literature review, this is the first application of the IC-PAD analytical technique for the determination of cyanide ions in meconium samples.

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Authors (4)

Ewa Jaszczak-Wilke
Krystyna Kozioł dr
Bogumiła Kiełbratowska dr
- Department of Obstetrics, Medical University of Gdansk
Żaneta Polkowska prof. dr hab. inż.

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DOI:: Digital Object Identifier (open in new tab) 10.3390/molecules26154672
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Category:: Articles
Type:: artykuły w czasopismach
Published in:: MOLECULES no. 26,
ISSN: 1420-3049
Language:: English
Publication year:: 2021
Bibliographic description:: Jaszczak-Wilke E., Kozioł K., Kiełbratowska B., Polkowska Ż.: Ion Chromatography with Pulsed Amperometric Detection for Determining Cyanide in Urine and Meconium Samples// MOLECULES -Vol. 26,iss. 15 (2021), s.4672-
DOI:: Digital Object Identifier (open in new tab) 10.3390/molecules26154672
Verified by:: Gdańsk University of Technology