Medical-Grade PCL Based Polyurethane System for FDM 3D Printing—Characterization and Fabrication - Publication - Bridge of Knowledge

Your account

login

Search

Medical-Grade PCL Based Polyurethane System for FDM 3D Printing—Characterization and Fabrication

Abstract

The widespread use of three-dimensional (3D) printing technologies in medicine has contributed to the increased demand for 3D printing materials. In addition, new printing materials that are appearing in the industry do not provide a detailed material characterization. In this paper, we present the synthesis and characterization of polycaprolactone (PCL) based medical-grade thermoplastic polyurethanes, which are suitable for forming in a filament that is dedicated to Fused Deposition Modeling 3D (FDM 3D)printers. For this purpose, we synthesized polyurethane that is based on PCL and 1,6-hexamethylene diisocyanate (HDI) with a different isocyanate index NCO:OH (0.9:1, 1.1:1). Particular characteristics of synthesized materials included, structural properties (FTIR, Raman), thermal (differential scanning calorimetry (DSC), thermogravimetric analysis (TGA)), mechanical and surfaces (contact angle) properties. Moreover, pre-biological tests in vitro and degradation studies were also performed. On the basis of the conducted tests, a material with more desirable properties S-TPU(PCL)0.9 was selected and the optimization of filament forming via melt-extrusion process was described. The initial biological test showed the biocompatibility of synthesized S-TPU(PCL)0.9 with respect to C2C12 cells. It was noticed that the process of thermoplastic polyurethanes (TPU) filaments forming by extrusion was significantly influenced by the appropriate ratio between the temperature profile, rotation speed, and dosage ratio.

Citations

  • 7 6

    CrossRef

  • 0

    Web of Science

  • 8 4

    Scopus

Authors (6)

Cite as

Full text

download paper
downloaded 67 times
Publication version
Accepted or Published Version
License
Creative Commons: CC-BY open in new tab

Keywords

Details

Category:
Articles
Type:
artykuł w czasopiśmie wyróżnionym w JCR
Published in:
Materials no. 12, edition 6, pages 1 - 18,
ISSN: 1996-1944
Language:
English
Publication year:
2019
Bibliographic description:
Haryńska A., Kucińska-Lipka J., Sulowska A., Gubańska I., Kostrzewa M., Janik H.: Medical-Grade PCL Based Polyurethane System for FDM 3D Printing—Characterization and Fabrication// Materials. -Vol. 12, iss. 6 (2019), s.1-18
DOI:
Digital Object Identifier (open in new tab) 10.3390/ma12060887
Bibliography: test
  1. Salentijn, G.I.J.; Oomen, P.E.; Grajewski, M.; Verpoorte, E. Fused Deposition Modeling 3D Printing for (Bio)analytical Device Fabrication: Procedures, Materials, and Applications. Anal. Chem. 2017, 89, 7053-7061. [CrossRef] [PubMed] open in new tab
  2. Skowyra, J.; Pietrzak, K.; Alhnan, M.A. Fabrication of extended-release patient-tailored prednisolone tablets via fused deposition modelling (FDM) 3D printing. Eur. J. Pharm. Sci. 2015, 68, 11-17. [CrossRef] open in new tab
  3. Mohseni, M.; Hutmacher, D.W.; Castro, N.J. Independent evaluation of medical-grade bioresorbable filaments for fused deposition modelling/fused filament fabrication of tissue engineered constructs. Polymers 2018, 10, 40. [CrossRef] open in new tab
  4. Okwuosa, T.C.; Stefaniak, D.; Arafat, B.; Isreb, A.; Wan, K.-W.; Alhnan, M.A. A Lower Temperature FDM 3D Printing for the Manufacture of Patient-Specific Immediate Release Tablets. Pharm. Res. 2016, 33, 2704-2712. [CrossRef] [PubMed] open in new tab
  5. Jung, S.Y.; Lee, S.J.; Kim, H.Y.; Park, H.S.; Wang, Z.; Kim, H.J.; Yoo, J.J.; Chung, S.M.; Kim, H.S. 3D printed polyurethane prosthesis for partial tracheal reconstruction: A pilot animal study. Biofabrication 2016, 8, 045015. [CrossRef] open in new tab
  6. Hung, K.C.; Tseng, C.S.; Hsu, S.H. Synthesis and 3D Printing of biodegradable polyurethane elastomer by a water-based process for cartilage tissue engineering applications. Adv. Healthc. Mater. 2014, 3, 1578-1587. [CrossRef] open in new tab
  7. Armentano, I.; Bitinis, N.; Fortunati, E.; Mattioli, S.; Rescignano, N.; Verdejo, R.; Lopez-Manchado, M.A.; Kenny, J.M. Multifunctional nanostructured PLA materials for packaging and tissue engineering. Prog. Polym. Sci. 2013, 38, 1720-1747. [CrossRef] open in new tab
  8. Seyednejad, H.; Ghassemi, A.H.; van Nostrum, C.F.; Vermonden, T. Functional aliphatic polyesters for biomedical and pharmaceutical applications. J. Control. Release 2011, 152, 168-176. [CrossRef] open in new tab
  9. Gogolewski, S.; Pennings, A.J. An artificial skin based on biodegradable mixtures of polylactides and polyurethanes for full-thickness skin wound covering. Die Makromol. Chemie Rapid Commun. 1983, 4, 675-680. [CrossRef] open in new tab
  10. Gogolewski, S.; Walpoth, B.; Rheiner, P. Polyurethane microporous membranes as pericardial substitutes. Colloid Polym. Sci. 1987, 265, 971-977. [CrossRef] open in new tab
  11. Gogolewski, S.; Galletti, G.; Ussia, G. Polyurethane vascular prostheses in pigs. Colloid Polym. Sci. 1987, 265, 774-778. [CrossRef] open in new tab
  12. Qiu, K.; Zhao, Z.; Haghiashtiani, G.; Guo, S.-Z.; He, M.; Su, R.; Zhu, Z.; Bhuiyan, D.B.; Murugan, P.; Meng, F.; et al. 3D Printed Organ Models with Physical Properties of Tissue and Integrated Sensors. Adv. Mater. Technol. 2017, 3, 1700235. [CrossRef] [PubMed] open in new tab
  13. Guelcher, S.A.; Gallagher, K.M.; Didier, J.E.; Klinedinst, D.B.; Doctor, J.S.; Goldstein, A.S.; Wilkes, G.L.; Beckman, E.J.; Hollinger, J.O. Synthesis of biocompatible segmented polyurethanes from aliphatic diisocyanates and diurea diol chain extenders. Acta Biomater. 2005, 1, 471-484. [CrossRef] [PubMed] open in new tab
  14. Tatai, L.; Moore, T.G.; Adhikari, R.; Malherbe, F.; Jayasekara, R.; Griffiths, I.; Gunatillake, P.A. Thermoplastic biodegradable polyurethanes: The effect of chain extender structure on properties and in-vitro degradation. Biomaterials 2007, 28, 5407-5417. [CrossRef] [PubMed] open in new tab
  15. Da Silva, G.R.; da Silva-Cunha, A.; Behar-Cohen, F.; Ayres, E.; Oréfice, R.L. Biodegradation of polyurethanes and nanocomposites to non-cytotoxic degradation products. Polym. Degrad. Stab. 2010, 95, 491-499. [CrossRef] open in new tab
  16. Haryńska, A.; Gubanska, I.; Kucinska-Lipka, J.; Janik, H. Fabrication and Characterization of Flexible Medical-Grade TPU Filament for Fused Deposition Modeling 3DP Technology. Polymers 2018, 10, 1304. [CrossRef] open in new tab
  17. Xiao, J.; Gao, Y. The manufacture of 3D printing of medical grade TPU. Prog. Addit. Manuf. 2017, 2, 117-123. [CrossRef] open in new tab
  18. Du, J.; Zhu, T.; Yu, H.; Zhu, J.; Sun, C.; Wang, J.; Chen, S.; Wang, J.; Guo, X. Potential applications of three-dimensional structure of silk fibroin/poly(ester-urethane) urea nanofibrous scaffold in heart valve tissue engineering. Appl. Surf. Sci. 2018, 447, 269-278. [CrossRef] open in new tab
  19. Barrioni, B.R.; De Carvalho, S.M.; Oréfice, R.L.; De Oliveira, A.A.R.; Pereira, M.D.M. Synthesis and characterization of biodegradable polyurethane films based on HDI with hydrolyzable crosslinked bonds and a homogeneous structure for biomedical applications. Mater. Sci. Eng. C 2015, 52, 22-30. [CrossRef] open in new tab
  20. Laube, T.; Weisser, J.; Berger, S.; Börner, S.; Bischoff, S.; Schubert, H.; Gajda, M.; Bräuer, R.; Schnabelrauch, M. In situ foamable, degradable polyurethane as biomaterial for soft tissue repair. Mater. Sci. Eng. C 2017, 78, 163-174. [CrossRef] open in new tab
  21. Chiono, V.; Mozetic, P.; Boffito, M.; Sartori, S.; Gioffredi, E.; Silvestri, A.; Rainer, A.; Giannitelli, S.M.; Trombetta, M.; Nurzynska, D.; et al. Polyurethane-based scaffolds for myocardial tissue engineering. Interface Focus 2014, 4, 1-11. [CrossRef] [PubMed] open in new tab
  22. Shahrousvand, M.; Hoseinian, M.S.; Ghollasi, M.; Karbalaeimahdi, A.; Salimi, A.; Tabar, F.A. Flexible magnetic polyurethane/Fe2O3 nanoparticles as organicinorganic nanocomposites for biomedical applications: Properties and cell behavior. Mater. Sci. Eng. C 2017, 74, 556-567. [CrossRef] [PubMed] open in new tab
  23. Lee, S.-Y.; Wu, S.-C.; Chen, H.; Tsai, L.-L.; Tzeng, J.-J.; Lin, C.-H.; Lin, Y.-M. Synthesis and Characterization of Polycaprolactone-Based Polyurethanes for the Fabrication of Elastic Guided Bone Regeneration Membrane. Biomed Res. Int. 2018, 2018, 1-13. [CrossRef] [PubMed] open in new tab
  24. Güney, A.; Gardiner, C.; McCormack, A.; Malda, J.; Grijpma, D. Thermoplastic PCL-b-PEG-b-PCL and HDI Polyurethanes for Extrusion-Based 3D-Printing of Tough Hydrogels. Bioengineering 2018, 5, 99. [CrossRef] [PubMed] open in new tab
  25. Fuenmayor, E.; Forde, M.; Healy, A.V.; Devine, D.M.; Lyons, J.G.; McConville, C.; Major, I. Material Considerations for Fused-Filament Fabrication of Solid Dosage Forms. Pharmaceutics 2018, 10, 44. [CrossRef] [PubMed] open in new tab
  26. Belter, J.T.; Dollar, A.M. Strengthening of 3D printed fused deposition manufactured parts using the fill compositing technique. PLoS ONE 2015, 10, e0122915. [CrossRef] [PubMed] open in new tab
  27. Zein, I.; Hutmacher, D.W.; Tan, K.C.; Teoh, S.H. Fused deposition modeling of novel scaffold architectures for tissue engineering applications. Biomaterials 2002, 23, 1169-1185. [CrossRef] open in new tab
  28. Puig, T.; Martin, J.; Polonio, E.; Guerra, A.; Rabionet, M.; Ciurana, J. Design of a Scaffold Parameter Selection System with Additive Manufacturing for a Biomedical Cell Culture. Materials 2018, 11, 1427.
  29. Ariadna, G.-P.; Marc, R.; Teresa, P.; Joaquim, C. Optimization of Poli(ε-caprolactone) Scaffolds Suitable for 3D Cancer Cell Culture. Procedia CIRP 2016, 49, 61-66. [CrossRef] open in new tab
  30. Kucinska-Lipka, J.; Marzec, M.; Gubanska, I.; Janik, H. Porosity and swelling properties of novel polyurethane-ascorbic acid scaffolds prepared by different procedures for potential use in bone tissue engineering. J. Elastomers Plast. 2017, 49, 440-456. [CrossRef] open in new tab
  31. Tanzi, M.C.; Verderio, P.; Lampugnani, M.G.; Resnati, M.; Dejana, E.; Sturani, E. Cytotoxicity of some catalysts commonly used in the synthesis of copolymers for biomedical use. J. Mater. Sci. Mater. Med. 1994, 5, 393-396. [CrossRef] open in new tab
  32. Heijkants, R.G.J.C.; Van Calck, R.V.; Van Tienen, T.G.; De Groot, J.H.; Buma, P.; Pennings, A.J.; Veth, R.P.H.; Schouten, A.J. Uncatalyzed synthesis, thermal and mechanical properties of polyurethanes based on poly(ε-caprolactone) and 1,4-butane diisocyanate with uniform hard segment. Biomaterials 2005, 26, 4219-4228. [CrossRef] open in new tab
  33. Kucińska-Lipka, J.; Malysheva, K.; Włodarczyk, D.; Korchynskyi, O.; Karczewski, J.; Kostrzewa, M.; Gubanska, I.; Janik, H. The Influence of Calcium Glycerophosphate (GPCa) Modifier on Physicochemical, Mechanical, and Biological Performance of Polyurethanes Applicable as Biomaterials for Bone Tissue Scaffolds Fabrication. Polymers 2017, 9, 329. [CrossRef] open in new tab
  34. Król, P.; Król, B.; Pielichowska, K.; Szałański, P.; Kobylarz, D. Polyurethanes modified by hydroxyapatite as biomaterials. Polimery 2015, 60, 559-571. [CrossRef] open in new tab
  35. Mucha, M.; Tylman, M.; Mucha, J. Crystallization kinetics of polycaprolactone in nanocomposites. Polimery 2015, 60, 686-692. [CrossRef] open in new tab
  36. Wurm, A.; Zhuravlev, E.; Eckstein, K.; Jehnichen, D.; Pospiech, D.; Androsch, R.; Wunderlich, B.; Schick, C. Crystallization and Homogeneous Nucleation Kinetics of Poly(ε-caprolactone) (PCL) with Different Molar Masses. Macromolecules 2012, 45, 3816-3828. [CrossRef] open in new tab
  37. Zhuravlev, E.; Schmelzer, J.W.P.; Wunderlich, B.; Schick, C. Kinetics of nucleation and crystallization in poly(ε-caprolactone) (PCL). Polymer 2011, 52, 1983-1997. [CrossRef] open in new tab
  38. Datta, J.; Kasprzyk, P.; Błażek, K.; Włoch, M. Synthesis, structure and properties of poly(ester-urethane)s obtained using bio-based and petrochemical 1,3-propanediol and 1,4-butanediol. J. Therm. Anal. Calorim. 2017, 130, 261-276. [CrossRef] open in new tab
  39. Suggs, L.J.; Moore, S.A.; Mikos, A.G. Synthetic Biodegradable Polymers for Medical Applications. In Physical Properties of Polymers Handbook; Springer: New York, NY, USA, 2007; pp. 939-950. open in new tab
  40. Kasprzyk, P.; Datta, J. Effect of molar ratio [NCO]/[OH] groups during prepolymer chains extending step on the morphology and selected mechanical properties of final bio-based thermoplastic poly(ether-urethane) materials. Polym. Eng. Sci. 2018, 58, E199-E206. [CrossRef] open in new tab
  41. Lee, D.-K.; Tsai, H.-B. Properties of segmented polyurethanes derived from different diisocyanates. J. Appl. Polym. Sci. 2000, 75, 167-174. [CrossRef] open in new tab
  42. Guelcher, S.A.; Srinivasan, A.; Dumas, J.E.; Didier, J.E.; McBride, S.; Hollinger, J.O. Synthesis, mechanical properties, biocompatibility, and biodegradation of polyurethane networks from lysine polyisocyanates. Biomaterials 2008, 29, 1762-1775. [CrossRef] [PubMed] open in new tab
  43. Menzies, K.L.; Jones, L. The impact of contact angle on the biocompatibility of biomaterials. Optom. Vis. Sci. 2010, 87, 387-399. [CrossRef] [PubMed] open in new tab
Sources of funding:
  • Część badań była finansowana z projektu Centrum Transferu Wiedzy i Technologii Politechniki Gdańskiej. Projekt nr 26
Verified by:
Gdańsk University of Technology

seen 234 times

Recommended for you

Fabrication and Characterization of Flexible Medical-Grade TPU Filament for Fused Deposition Modeling 3DP Technology

2018

Polyurethanes as a Potential Medical-Grade Filament for Use in Fused Deposition Modeling 3D Printers – a Brief Review

2018

Composite Polyurethane-Polylactide (PUR/PLA) Flexible Filaments for 3D Fused Filament Fabrication (FFF) of Antibacterial Wound Dressings for Skin Regeneration

2021

A comprehensive evaluation of flexible FDM/FFF 3D printing filament as a potential material in medical application

2020
Meta Tags