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Abstract
The new conjugates of mycophenolic acid (MPA) were obtained in the reaction of N6-(ω-aminoalkyl)adenosines with MPA in the presence of EDCI as a coupling reagent. New compounds 4a–h were evaluated on leukemia cell line (Jurkat) and PBMC from healthy donors. Length of the linker influenced observed activity. The compound 4b possessing 1,3-diamine spacer exhibited the most promising results and can be considered to further investigations.
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Authors (5)
-
Piotr Trzonkowski
- GUMed Zakład Immunologii i Transplantologii
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Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
no. 18,
edition 11,
pages 1057 - 1062,
ISSN: 1028-6020 - Language:
- English
- Publication year:
- 2016
- Bibliographic description:
- Prejs M., Cholewiński G., Siebert A., Trzonkowski P., Dzierzbicka K.: New conjugates of mycophenolic acid and their antiproliferative activity// JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH. -Vol. 18, iss. 11 (2016), s.1057-1062
- DOI:
- Digital Object Identifier (open in new tab) 10.1080/10286020.2016.1184653
- Verified by:
- Gdańsk University of Technology
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