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Abstract
Abstract: Five-membered 1,2,4-oxadiazole heterocyclic ring has received considerable attention because of its unique bioisosteric properties and an unusually wide spectrum of biological activities. Thus, it is a perfect framework for the novel drug development. After a century since the 1,2,4-oxadiazole have been discovered, the uncommon potential attracted medicinal chemists’ attention, leading to the discovery of a few presently accessible drugs containing 1,2,4-oxadiazole unit. It is worth noting that the interest in a 1,2,4-oxadiazoles’ biological application has been doubled in the last fifteen years. Herein, after a concise historical introduction, we present a comprehensive overview of the recent achievements in the synthesis of 1,2,4-oxadiazole-based compounds and the major advances in their biological applications in the period of the last five years as well as brief remarks on prospects for further development.
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Authors (6)
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Konrad Kubiński
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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Pharmaceuticals
no. 13,
ISSN: 1424-8247 - Language:
- English
- Publication year:
- 2020
- Bibliographic description:
- Biernacki K., Daśko M., Ciupak O., Kubiński K., Rachoń J., Demkowicz S.: Novel 1,2,4-Oxadiazole Derivatives in Drug Discovery// Pharmaceuticals -Vol. 13,iss. 6 (2020), s.111-
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/ph13060111
- Verified by:
- Gdańsk University of Technology
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