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Structural changes of bacterial cellulose due to incubation in conditions simulating human plasma in the presence of selected pathogens
Abstract
Bacterial nanocellulose (BNC) is a natural biomaterial with a wide range of medical applications. However, it cannot be used as a biological implant of the circulatory system without checking whether it is biodegradable under human plasma conditions. This work aimed to investigate the BNC biodegradation by selected pathogens under conditions simulating human plasma. The BNC was incubated in simulated biological fluids with or without Staphylococcus aureus, Candida albicans and Aspergillus fumigatus, and its physicochemical properties were studied. The results showed that the incubation of BNC in simulated body fluid with A. fumigatus con-tributes more to its degradation than that under other conditions tested. The rearrangement of the hydrogen- bond network in this case resulted in a more compact structure, with an increased crystallinity index, reduced thermal stability and looser cross-linking. Therefore, although BNC shows great potential as a cardiovascular implant material, before use for this purpose its biodegradability should be limited.
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Authors (3)
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Paulina Dederko-Kantowicz
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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CARBOHYDRATE POLYMERS
no. 266,
ISSN: 0144-8617 - Language:
- English
- Publication year:
- 2021
- Bibliographic description:
- Dederko-Kantowicz P., Sommer A., Staroszczyk H.: Structural changes of bacterial cellulose due to incubation in conditions simulating human plasma in the presence of selected pathogens// CARBOHYDRATE POLYMERS -Vol. 266, (2021), s.118153-
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.carbpol.2021.118153
- Sources of funding:
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- IDUB
- Verified by:
- Gdańsk University of Technology
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