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Abstract
6-Sulfo-6-deoxy-D-glucosamine (GlcN6S), 6-sulfo-6-deoxy-D-glucosaminitol (ADGS) and their N-acetyl and methyl ester derivatives have been synthesized and tested as inhibitors of enzymes catalyzing reactions of the UDP-GlcNAc pathway in bacteria and yeasts. GlcN6S and ADGS at micromolar concentrations inhibited glucosamine-6-phosphate (GlcN6P) synthase of microbial origin. The former was also inhibitory towards fungal GlcN6P N-acetyl transferase, but at millimolar concentrations. Both compounds and their N-acetyl derivatives exhibited antimicrobial in vitro activity, with MICs in the 0.125–2.0 mg mL−1 range. Antibacterial but not antifungal activity of GlcN6S was potentiated by D-glucosamine and a synergistic antibacterial effect was observed for combination of ADGP and a dipeptide Nva-FMDP.
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Authors (8)
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Muna Khan
- Department of Microbiology Immunobiology and Genetics
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Görke Boris
- Department of Microbiology Immunobiology and Genetics
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Details
- Category:
- Articles
- Type:
- artykuł w czasopiśmie wyróżnionym w JCR
- Published in:
-
CARBOHYDRATE RESEARCH
no. 448,
pages 79 - 87,
ISSN: 0008-6215 - Language:
- English
- Publication year:
- 2017
- Bibliographic description:
- Skarbek K., Gabriel I., Szweda P., Wojciechowski M., Khan M., Boris G., Milewski S., Milewska M.: Synthesis and antimicrobial activity of 6-sulfo-6-deoxy-D-glucosamine and its derivatives// CARBOHYDRATE RESEARCH. -Vol. 448, (2017), s.79-87
- DOI:
- Digital Object Identifier (open in new tab) 10.1016/j.carres.2017.06.002
- Verified by:
- Gdańsk University of Technology
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