Synthesis and antimicrobial activity of 6-sulfo-6-deoxy-D-glucosamine and its derivatives - Publikacja - MOST Wiedzy

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Synthesis and antimicrobial activity of 6-sulfo-6-deoxy-D-glucosamine and its derivatives

Abstrakt

6-Sulfo-6-deoxy-D-glucosamine (GlcN6S), 6-sulfo-6-deoxy-D-glucosaminitol (ADGS) and their N-acetyl and methyl ester derivatives have been synthesized and tested as inhibitors of enzymes catalyzing reactions of the UDP-GlcNAc pathway in bacteria and yeasts. GlcN6S and ADGS at micromolar concentrations inhibited glucosamine-6-phosphate (GlcN6P) synthase of microbial origin. The former was also inhibitory towards fungal GlcN6P N-acetyl transferase, but at millimolar concentrations. Both compounds and their N-acetyl derivatives exhibited antimicrobial in vitro activity, with MICs in the 0.125–2.0 mg mL−1 range. Antibacterial but not antifungal activity of GlcN6S was potentiated by D-glucosamine and a synergistic antibacterial effect was observed for combination of ADGP and a dipeptide Nva-FMDP.

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Informacje szczegółowe

Kategoria:
Publikacja w czasopiśmie
Typ:
artykuł w czasopiśmie wyróżnionym w JCR
Opublikowano w:
CARBOHYDRATE RESEARCH nr 448, strony 79 - 87,
ISSN: 0008-6215
Język:
angielski
Rok wydania:
2017
Opis bibliograficzny:
Skarbek K., Gabriel I., Szweda P., Wojciechowski M., Khan M., Boris G., Milewski S., Milewska M.: Synthesis and antimicrobial activity of 6-sulfo-6-deoxy-D-glucosamine and its derivatives// CARBOHYDRATE RESEARCH. -Vol. 448, (2017), s.79-87
DOI:
Cyfrowy identyfikator dokumentu elektronicznego (otwiera się w nowej karcie) 10.1016/j.carres.2017.06.002
Weryfikacja:
Politechnika Gdańska

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