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Abstract
The factors enablingCandidaspp. infections are secretion of hydrolytic enzymes, adher-ence to surfaces, biofilm formation or morphological transition, and fitness attributes. The aim of thisstudy was to investigate the correlation between known extracellular virulence factors and survivalofGalleria mellonellalarvae infected with clinicalCandida. The 25 isolates were tested and the activityof proteinases among 24/24, phospholipases among 7/22, esterases among 14/23, hemolysins among18/24, and biofilm formation ability among 18/25 isolates was confirmed. Pathogenicity investiga-tion usingG. mellonellalarvae as host model demonstrated thatC. albicansisolates andC. glabrataisolate were the most virulent andC. kruseiisolates were avirulent.C. parapsilosisvirulence wasidentified as varied,C. inconspicuawere moderately virulent, and oneC. palmioleophilaisolate was oflow virulence and the remaining isolates of this species were moderately virulent. According to ourstudy, virulence ofCandidaisolates is related to the expression of proteases, hemolysins, and esterases.
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- Category:
- Articles
- Type:
- artykuły w czasopismach
- Published in:
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Pathogens
no. 10,
ISSN: 2076-0817 - Language:
- English
- Publication year:
- 2021
- Bibliographic description:
- Mroczyńska M., Brillowska-Dąbrowska A.: Virulence of Clinical Candida Isolates// Pathogens -,iss. 10 (4) (2021), s.1-12
- DOI:
- Digital Object Identifier (open in new tab) 10.3390/pathogens10040466
- Verified by:
- Gdańsk University of Technology
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