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X-ray and UV Radiation Damage of dsDNA/Protein Complexes

Abstract

Radiation and photodynamic therapies are used for cancer treatment by targeting DNA. However, efficiency is limited due to physico-chemical processes and the insensitivity of native nucleobases to damage. Thus, incorporation of radio- and photosensitizers into these therapies should increase both efficacy and the yield of DNA damage. To date, studies of sensitization processes have been performed on simple model systems, e.g., buffered solutions of dsDNA or sensitizers alone. To fully understand the sensitization processes and to be able to develop new efficient sensitizers in the future, well established model systems are necessary. In the cell environment, DNA tightly interacts with proteins and incorporating this interaction is necessary to fully understand the DNA sensitization process. In this work, we used dsDNA/protein complexes labeled with photo- and radiosensitizers and investigated degradation pathways using LC-MS and HPLC after X-ray or UV radiation.

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Category:
Articles
Type:
artykuły w czasopismach
Published in:
MOLECULES no. 26,
ISSN: 1420-3049
Language:
English
Publication year:
2021
Bibliographic description:
Wityk P., Kostrzewa-Nowak, D., Krawczyk B., Michalik M., Nowak R.: X-ray and UV Radiation Damage of dsDNA/Protein Complexes// MOLECULES -Vol. 26,iss. 11 (2021), s.3132-
DOI:
Digital Object Identifier (open in new tab) 10.3390/molecules26113132
Verified by:
Gdańsk University of Technology

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