Filters
total: 2462
filtered: 1041
displaying 1000 best results Help
Search results for: targeted cancer therapy
-
The Influence of Antitumor Unsymmetrical Bisacridines on 3D Cancer Spheroids Growth and Viability
PublicationThe culture of 3D spheroids is a promising tool in drug development and testing. Recently, we synthesized a new group of compounds, unsymmetrical bisacridines (UAs), which exhibit high cytotoxicity against various human cell lines and antitumor potency against several xenografts. Here, we describe the ability of four UAs—C-2028, C-2041, C-2045, and C-2053—to influence the growth of HCT116 and H460 spheres and the viability of HCT116...
-
Improved cytotoxicity and preserved level of cell death induced in colon cancer cells by doxorubicin after its conjugation with iron-oxide magnetic nanoparticles
PublicationA promising strategy for overcoming the problem of limited efficacy in antitumor drug delivery and in drug release is the use of a nanoparticle-conjugated drug. Doxorubicin (Dox) anticancer chemotherapeutics has been widely studied in this respect, because of severe cardiotoxic side effects. Here, we investigated the cytotoxic effects, the uptake process, the changes in cell cycle progression and the cell death processes in the...
-
Differential Response of MDA-MB-231 and MCF-7 Breast Cancer Cells to In Vitro Inhibition with CTLA-4 and PD-1 through Cancer-Immune Cells Modified Interactions
Publication -
Association of Hepcidin mRNA Expression With Hepatocyte Iron Accumulation and Effects of Antiviral Therapy in Chronic Hepatitis C Infection
Publication -
Theophylline Therapy for Cheyne-Stokes Respiration During Sleep in a 41-Year-Old Man With Refractory Arterial Hypertension
Publication -
Interferon‐free therapy as the cause of white matter tracts and cerebral perfusion recovery in patients with chronic hepatitis C
Publication -
Physical and Mechanical Evaluation of Silicone-Based Double-Layer Adhesive Patch Intended for Keloids and Scar Treatment Therapy
PublicationGrowing interest in silicone elastomers for pharmaceutical purposes is due to both theirbeneficial material effect for scar treatment and their potential as drug carriers. Regarding their morphological structure, silicone polymers possess unique properties, which enable a wide range of applicability possibilities. The present study focused on developing a double-layer adhesive silicone film (DLASil) by evaluating its physical...
-
Increased Levels of Platelets and Endothelial-Derived Microparticles in Patients With Non-Valvular Atrial Fibrillation During Rivaroxaban Therapy
Publication -
Physical and Mechanical Evaluation of Silicone-Based Double-Layer Adhesive Patch Intended for Keloids and Scar Treatment Therapy
Publication -
Comparison of siRNA-mediated silencing of glycosaminoglycan synthesis genes and enzyme replacement therapy for mucopolysaccharidosis in cell culture studies.
Publication -
Dual-Activity Fluoroquinolone-Transportan 10 Conjugates offer alternative Leukemia therapy during Hematopoietic Cell Transplantation
PublicationHematopoietic cell transplantation (HCT) is often considered a last resort leukemia treatment, fraught with limited success due to microbial infections, a leading cause of mortality in leukemia patients. To address this critical issue, we explored a novel approach by synthesizing antileukemic agents containing antibacterial substances. This innovative strategy involves conjugating fluoroquinolone antibiotics, such as ciprofloxacin...
-
The Occurrence of Cancer and of Adenomae in the Large Bowel and the Concentration of N -Nitrosamines in the Gastric Juice
Publication -
Advanced Assessment of the Endogenous Hormone Level as a Potential Biomarker of the Urogenital Tract Cancer
Publication -
The Relationship of Purpose in Life and Hope in Shaping Happiness Among Patients with Cancer in Poland
Publication -
Role of Curcumin and (−)-Epigallocatechin-3-O-Gallate in Bladder Cancer Treatment: A Review
Publication -
Delving into the Nutraceutical Benefits of Purple Carrot against Metabolic Syndrome and Cancer: A Review
Publication -
Altered circadian genes expression in breast cancer tissue according to the clinical characteristics
Publication -
The impact of the Polish mass breast cancer screening program on prognosis in the Pomeranian Province
Publication -
Prognostic Significance of TOP2A Gene Dosage in HER-2-Negative Breast Cancer
Publication -
Polymorphisms in nucleotide excision repair genes and susceptibility to colorectal cancer in the Polish population
Publication -
The Role of miRNA in Papillary Thyroid Cancer in the Context of miRNA Let-7 Family
Publication -
Altered levels of circulating nuclear and mitochondrial DNA in patients with Papillary Thyroid Cancer
Publication -
Prognostic value of 5-microRNA based signature in T2-T3N0 colon cancer
Publication -
Synthesis of Usnic Acid Derivatives and Evaluation of Their Antiproliferative Activity against Cancer Cells
Publication -
Saliva as a first-line diagnostic tool: A spectral challenge for identification of cancer biomarkers
Publication -
Application of a three‑dimensional (3D) breast cancer model to study macrophage polarization
Publication -
Tissue Rheology as a Possible Complementary Procedure to Advance Histological Diagnosis of Colon Cancer
Publication -
Bayesian multilevel model of micro RNA levels in ovarian-cancer and healthy subjects
Publication -
Myeloid-derived suppressor cells (MDSCs) in brain cancer: challenges and therapeutic strategies
Publication -
From chemoresistance to cancer stem cells: the case of BRCP/ABCG2 half transporter
PublicationLudzkie białko ABCG2 jest pompą typu ABC tworzącą homodimery i aktywnie transportującą leki i inne substraty naturalne i syntetyczne. Nadekspresja tego białko prowadzi do oporności na leki przeciwnowotworowe. Białko ABCG2 występuje w wielu formach zmutowanych, różniących się własnościami substratowymi, stąd istotne dla oporności na leki jest jaka forma genu i białka ABCG2 ulega nadekspresji w komórce. Ostatnie badania wskazują,...
-
Vimentin immunoexpression and its prognostic activity in colon cancer among Caucasian patients
Publication -
Near-Infrared Fluorescence Image-Guided Surgery in Esophageal and Gastric Cancer Operations
Publication -
Deep Learning-Based, Multiclass Approach to Cancer Classification on Liquid Biopsy Data
Publication -
FGF7 / FGFR2 – JunB signalling counteracts the effect of progesterone in luminal breast cancer
Publication -
Risk factors assessment and risk prediction models in lung cancer screening candidates
Publication -
Can popular films instil carcinophobia? Images of cancer in popular Polish cinema
Publication -
Impacting the Remedial Potential of Nano Delivery-Based Flavonoids for Breast Cancer Treatment
Publication -
Potential plasma biomarkers of bladder cancer identified by proteomic analysis: A pilot study
Publication -
Designing a high-sensitivity dual-band nano-biosensor based on petahertz MTMs to provide a perfect absorber for early-stage non-melanoma skin cancer diagnostic
PublicationThe purpose of this study is development of a novel high-performance low-Petahertz (PHz) biosensor for non-melanoma skin cancer (NMSC) diagnosis. The presented device is designed to work within a microwave imaging regime, which is a promising alternative to conventional diagnostic methods such as visual examination, dermoscopy, and biopsy. The suggested biosensor incorporates a dual-band perfect absorber (operating bands at 0.909...
-
Comparison of the effects of rosuvastatin monotherapy and atorvastatin-ezetimibe combined therapy on the structure of erythrocyte membranes in patients with coronary artery disease
Publication -
Neutrocyte-to-lymphocyte ratio predicts the presence of a replicative hepatitis C virus strand after therapy with direct-acting antivirals
Publication -
Population pharmacokinetics of standard-dose meropenem in critically ill patients on continuous renal replacement therapy: a prospective observational trial
Publication -
Xanthine Oxidoreductase Activity in Platelet-Poor and Rich Plasma As a Oxidative Stress Indicator in Patients Required Renal Replacement Therapy
Publication -
Xanthine oxidoreductase activity in platelet-poor and rich plasma as a oxidative stress indicator in patients required renal replacement therapy
Publication -
Visual and brainstem auditory evoked potentials in HCV-infected patients before and after interferon-free therapy — A pilot study
Publication -
Selective Cytostatic and Cytotoxic Anticancer Effects of Bisfunctional Agents: A Strategy for the Design of DNA Binding Agents
PublicationVarious agents have been synthesized and proved useful for the National Cancer Institute's anticancer testing as potential new drugs, but most agents suffer side effects from their limited selectivity against cancer cells over healthy ones. Therefore, this paper attempts to describe drugs in terms of the level of tumor cell selectivity which they possess to define the features of mols. that are essential for useful cytotoxicity....
-
Patient with metastatic breast cancer presenting as acute cholecystitis with one-year survival on hormonotherapy
Publication -
Altered levels of nucleoside metabolite profiles in urogenital tract cancer measured by capillary electrophoresis
Publication -
Liquid chromatography tandem mass spectrometry study of urinary nucleosides as potential cancer markers
Publication -
Analysis of urinary nucleosides as potential cancer markers determined using LC–MS technique
Publication