Search results for: liver cell microsomes

• One-tube cell lysis and DNA extraction procedure for PCR based detection of Mycobacterium ulcerans in aquatic insects, molluscs and fish.

  Publication

  • R. Kotlowski
  • A. Martin
  • A. Ablordey
  • K. Chemlal
  • P. Fonteyne
  • F. Portaels

  - Year 2004

  Mycobacterium ulcerans jest bakterią wywołującą choroby skóry u ludzi i zwierząt. W trakcie prowadzonych badań opracowano prostą w wykonaniu metodę ekstrakcji DNA Mycobacterium ulcerans z próbek środowiskowych oraz klinicznych. Opracowana metoda izolacji DNA może być przydatna w badaniu źródeł infekcji oraz dróg szerzenia się Mycobacterium ulcerans.

• Increased susceptibility of PARP-1 KO cells to antitumor triazoloacridone C-1305 is associated with permanent G2 cell cycle arrest.

  Publication

  • J. Węsierska-Gądek
  • D. Schloffer
  • M. Gueorguieva
  • M. Uhl
  • A. Składanowski

  - Year 2004

  Triazoloakrydon C-1305 jest nowym inhibitorem topoizomerazy II wykazującym wysoką aktywność przeciwnowotworową. W tej pracy badaliśmy działanie cytotoksyczne pochodnej C-1305 i jej analogu strukturalnego C-1533 wobec komórek fibroblastów mysich i dwóch mutantów, w których uszkodzono gen PARP-1. Jak wykazaliśmy, komórki z uszkodzonym genem PARP-1 są nadwrażliwe na działanie związku C-1305 w porównaniu z komórkami PARP-1 +/+ podczas...

• The influence of 4-substituted and unsubstituted derivatives of 1-nitroacridine on the cell cycle and induction of apoptosis in human cancer HT29 and HeLa S3.

  Publication

  • A. Moś-Rompa
  • E. Augustin
  • J. Konopa

  - Year 2004

  Zbadano wpływ pochodnych 1-nitroakrydyny C-1748 i C-857, w stężeniach biologicznie istotnych, na cykl życiowy oraz indukcję apoptozy komórek raka jelita grubego HT29 oraz raka szyjki macicy HeLa S3. Metodą cytometrii przepływowej wykazano, że 4-metylo-1-nitroakrydyna C-1748 powoduje akumulację komórek HT29 w fazie S i komórek HeLa S3 w fazie G2 cyklu komórkowego zaś związek C-857 indukuje akumulację komórek HT29 i HeLa S3 w fazie...

• The extended version of restriction analysis approach for the examination of the ability of low-molecular-weight compounds to modify DNA in a cell-free system

  Publication

  • D. Kołodziejski
  • A. Brillowska-Dąbrowska
  • A. Bartoszek-Pączkowska

  - FOOD AND CHEMICAL TOXICOLOGY - Year 2015

  One of the primary requirements in toxicology is the assessment of ability of chemicals to induce DNA covalent modification. There are several well-established methods used for this purpose such as 32P-Postlabeling or HPLC-MS. However, all of these approaches have difficult to overcome limitations, which prevents their use in genotoxin screening. Here, we describe the simple protocol exploiting specificity of restriction enzymes...

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• Osteoblast and bacterial cell response on RGD peptide‐functionalized chitosan coatings electrophoretically deposited from different suspensions on Ti13Nb13Zr alloy

  Publication

  • Ł. Pawłowski
  • S. Mania
  • A. Banach-Kopeć
  • M. Bartmański
  • A. Ronowska
  • K. Jurak
  • A. D. Mielewczyk-Gryń
  • N. Karska
  • S. Rodziewicz-Motowidło
  • A. Zieliński

  - JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS - Year 2023

  Metallic materials for long-term load-bearing implants still do not provide high antimicrobial activity while maintaining strong compatibility with bone cells. This study aimed to modify the surface of Ti13Nb13Zr alloy by electrophoretic deposition of a chitosan coating with a covalently attached Arg-Gly-Asp (RGD) peptide. The suspensions for coating deposition were prepared in two different ways either using hydroxyacetic acid...

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• Imidazoacridinone-dependent lysosomal photodestruction: a pharmacological Trojan horse approach to eradicate multidrug-resistant cancers

  Publication

  • Y. Adar
  • M. Stark
  • E. E. Bram
  • P. Nowak-Sliwinska
  • H. van den Bergh
  • G. Szewczyk
  • T. Sarna
  • A. Skladanowski
  • A. Griffoen
  • Y. G. Assaraf

  - Cell Death and Disease - Year 2012

  Multidrug resistance (MDR) remains a primary hindrance to curative cancer therapy. Thus, introduction of novel strategies to overcome MDR is of paramount therapeutic significance. Sequestration of chemotherapeutics in lysosomes is an established mechanism of drug resistance. Here, we show that MDR cells display a marked increase in lysosome number. We further demonstrate that imidazoacridinones (IAs), which are cytotoxic fluorochromes,...

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• Diffuse large B-cell lymphoma, germinal center B-cell subtype - Female, 73 - Tissue image [1230630016183201]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Diffuse large B-cell lymphoma, germinal center B-cell subtype - Female, 73 - Tissue image [1230630016182071]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Diffuse large B-cell lymphoma, germinal center B-cell subtype - Female, 73 - Tissue image [1230630016186761]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Diffuse large B-cell lymphoma, germinal center B-cell subtype - Female, 73 - Tissue image [1230630016187891]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Other and unspecified cirrhosis of liver - Female, 70 - Tissue image [5180730014267871]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of THYROID GLAND tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Diffuse large B-cell lymphoma, germinal center B-cell subtype - Female, 73 - Tissue image [1230630016188311]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Diffuse large B-cell lymphoma, germinal center B-cell subtype - Female, 73 - Tissue image [1230630016185251]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Diffuse large B-cell lymphoma, germinal center B-cell subtype - Female, 73 - Tissue image [1230630016184211]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Diffuse large B-cell lymphoma, germinal center B-cell subtype - Female, 73 - Tissue image [1230630016185761]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Diffuse large B-cell lymphoma, germinal center B-cell subtype - Female, 73 - Tissue image [1230630016184091]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of UNKNOWN PRIMARY SITE tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Other and unspecified cirrhosis of liver - Female, 70 - Tissue image [5180730014265571]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of THYROID GLAND tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Male, 65 - Tissue image [529073002550931]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Male, 65 - Tissue image [5290730025505111]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Male, 65 - Tissue image [5290730025504381]

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Female, 69 - Tissue image [6190730017347681]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Male, 69 - Tissue image [6180730013784871]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Male, 69 - Tissue image [61807300137831]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Female, 69 - Tissue image [6190730017349921]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Male, 69 - Tissue image [6180730013788441]

  Open Research Data

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  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Female, 69 - Tissue image [619073001734801]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Male, 69 - Tissue image [6180730013797321]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Male, 69 - Tissue image [5290730025501971]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Female, 77 - Tissue image [6190730017343501]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Male, 57 - Tissue image [5300730025879481]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Male, 57 - Tissue image [5300730025879381]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Female, 77 - Tissue image [619073001734751]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Male, 57 - Tissue image [530073002587901]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Female, 77 - Tissue image [6190730017347281]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Female, 64 - Tissue image [5290730025513781]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Male, 69 - Tissue image [5290730025509651]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Male, 69 - Tissue image [5290730025501541]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Female, 64 - Tissue image [5290730025514501]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Female, 77 - Tissue image [6190730017349791]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Female, 77 - Tissue image [6190730017344661]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Male, 57 - Tissue image [5300730025873421]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Female, 77 - Tissue image [6190730017344221]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Female, 64 - Tissue image [5290730025517441]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Female, 77 - Tissue image [619073001734791]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Male, 57 - Tissue image [5300730025872711]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Male, 57 - Tissue image [5300730025875421]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 1000 slide scanner (20x magnification) and saved to DICOM format.

• Clear cell renal cell carcinoma, NOS - Female, 77 - Tissue image [6190730017342541]

  Open Research Data

  open access

  • Gdański Uniwersytet Medyczny

  This is the histopathological image of KIDNEY tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.

• Designing efficient A-D-A1-D-A type fullerene free acceptor molecules with enhanced power conversion efficiency for solar cell applications

  Publication

  • M. M. Iqbal Asif
  • M. Arshad
  • M. Y. Mehboob
  • M. S. Khan
  • S. Piracha

  - SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY - Year 2023

  The achievement of highly efficient power conversion efficiency (PCE) is a big concern for non-fullerene organic solar cells (NF-OSCs) because PCE can depend on numerous variables. Here, new five novel acceptor molecules without fullerenes were developed and investigated using DFT (density functional theory) and TD-DFT (time dependent-density functional theory). Compared to the recently synthesized molecule (PZ-dIDTC6), the developed...

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• Triazoloacridone C-1305 abrogates the restriction checkpoint in cells lacking functional p53 and promotes their accumulation in the G2/M phase of the cell cycle

  Publication

  • M. Mauer
  • O. Komina
  • A. Składanowski
  • J. Wesierska-Gadek

  - Journal of Experimental Therapeutis and Oncology - Year 2011

  Triazoloakrydon C-1305, nowy inhibitor topoizomerazy II, wykazuje wysoką aktywość cytotoksyczną wobec komórek wielu typów nowotworów. Komórki mysie pozbawione genu PARP-1 wykazywały nadwrażliwość na działanie tego związku. W pracy testowaliśmy działanie związku wobec dwóch różnych komóek nowotworowych różniących się statusem p53: komórkami białaczki myelocytarnej HL-60 i raka sutka MCF-7. Wykazaliśmy, że inkubacja ze związkiem...

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• Viability and intracellular nitric oxide generation in the umbilical cord blood CD34+CD133– and CD34+CD133+ cell populations exposed to local anaesthetics

  Publication

  • K. Kulińska
  • H. Billert
  • K. Sawiński
  • K. Czerniak
  • M. Kurpisz

  - Central European Journal of Immunology - Year 2020

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