Search results for: dna sensitization - Bridge of Knowledge

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Search results for: dna sensitization

Search results for: dna sensitization

  • Generation and Characterization of a DNA-GCN4 Oligonucleotide-Peptide Conjugate: The Impact DNA/Protein Interactions on the Sensitization of DNA

    Publication

    - MOLECULES - Year 2020

    Radiotherapy, the most common therapy for the treatment of solid tumors, exerts its effects by inducing DNA damage. To fully understand the extent and nature of this damage, DNA models that mimic the in vivo situation should be utilized. In a cellular context, genomic DNA constantly interacts with proteins and these interactions could influence both the primary radical processes (triggered by ionizing radiation) and secondary reactions,...

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  • X-ray and UV Radiation Damage of dsDNA/Protein Complexes

    Publication

    - MOLECULES - Year 2021

    Radiation and photodynamic therapies are used for cancer treatment by targeting DNA. However, efficiency is limited due to physico-chemical processes and the insensitivity of native nucleobases to damage. Thus, incorporation of radio- and photosensitizers into these therapies should increase both efficacy and the yield of DNA damage. To date, studies of sensitization processes have been performed on simple model systems, e.g.,...

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  • Mechanisms of Damage to DNA Labeled with Electrophilic Nucleobases Induced by Ionizing or UV Radiation

    Publication
    • J. Rak
    • L. Chomicz-Mańka
    • J. Wiczk
    • K. Westphal
    • M. Zdrowowicz
    • P. Wityk
    • M. Żyndul
    • S. Makurat
    • Ł. Golon

    - JOURNAL OF PHYSICAL CHEMISTRY B - Year 2015

    Hypoxia—a hallmark of solid tumors—makes hypoxic cells radioresistant. On the other hand, DNA, the main target of anticancer therapy, is not sensitive to the near UV photons and hydrated electrons, one of the major products of water radiolysis under hypoxic conditions. A possible way to overcome these obstacles to the efficient radio- and photodynamic therapy of cancer is to sensitize the cellular DNA to electrons and/or ultraviolet...

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  • Radio- and photosensitization of DNA with compounds containing platinum and bromine atoms

    Publication

    - EUROPEAN PHYSICAL JOURNAL D - Year 2015

    . Irradiations of plasmid DNA by both X-rays and UV light in the presence and absence of compounds containing platinum and bromine atoms were performed in order to asses the sensitization potential of these compounds. Plasmid DNA pBR322 was incubated with platinum (II) bromide, hydrogen hexabromoplatinate (IV), hydrogen hexahydroxyplatinate (IV) and sodium hexahydroxyplatinate (IV). Incubation was followed by X-ray or UV irradiations....

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  • 5-Bromo-2′-deoxycytidine—a potential DNA photosensitizer

    Publication

    - ORGANIC & BIOMOLECULAR CHEMISTRY - Year 2016

    A double-stranded oligonucleotide, 80 base pairs in length, was multiply labeled with 5-bromo-2′-deoxycytidine (BrdC) using polymerase chain reaction (PCR). The modified oligonucleotide was irradiated with 300 nm photons and its damage was assayed by employing DHPLC, LC-MS and denaturing polyacrylamide gel electrophoresis (PAGE). Two types of damage were demonstrated, namely, single strand breaks (SSBs) and intrastrand cross-links...

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