Search results for: benzeneboronic acid

• AMINO ACIDS

  Journals

  ISSN: 0939-4451 , eISSN: 1438-2199

• NUCLEIC ACIDS RESEARCH

  Journals

  ISSN: 0305-1048 , eISSN: 1362-4962

• Nucleic Acid Therapeutics

  Journals

  ISSN: 2159-3337 , eISSN: 2159-3345

• Arid Ecosystems

  Journals

  ISSN: 2079-0961 , eISSN: 2079-0988

• Synthesis and biological activity of mycophenolic acid-amino acid derivatives

  Publication

  • D. Iwaszkiewicz-Grzes
  • G. Cholewinski
  • A. Kot-Wasik
  • P. Trzonkowski
  • K. Dzierzbicka

  - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - Year 2013

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• Synthesis and biological activity of mycophenolic acid-amino acid derivatives

  Publication

  • D. Iwaszkiewicz-Grześ
  • G. Cholewiński
  • A. Kot-Wasik
  • P. Trzonkowski
  • K. Dzierzbicka

  - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - Year 2013

  In search of new immunosuppressants, mycophenolic acid (MPA) was coupled with amino acid methyl esters followed by hydrolysis to analogs bearing free carboxylic groups. The obtained compunds were tested in vitro as growth inhibitors of lymphoid cell line (Jurkat) and human peripheral blood mononuclear cells (PBMC) from healthy donors. According to obtained results recovering of free carboxylic group increased their activity. Additionally,...

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• Immunosuppressive properties of amino acid and peptide derivatives of mycophenolic acid

  Publication

  • A. Siebert
  • G. Cholewiński
  • P. Trzonkowski
  • J. Rachoń

  - EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - Year 2020

  Mycophenolic acid (MPA) was coupled with amino acids and biologically active peptides including derivatives of tuftsin to modify its immunosuppressive properties. Both amino acid unit in the case of simple MPA amides and modifications within peptide moiety of MPA - tuftsin conjugates influenced the observed activity. Antiproliferative potential of the obtained conjugates was investigated in vitro and MPA amides with threonine methyl...

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• Hyaluronic acid/tannic acid films for wound healing application

  Publication

  • M. Wekwejt
  • M. Małek
  • A. Ronowska
  • A. Michno
  • A. Pałubicka
  • A. Klimek
  • B. Kaczmarek-Szczepańska

  - INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES - Year 2024

  In this study, thin films based on hyaluronic acid (HA) with tannic acid (TA) were investigated in three different weight ratios (80HA/20TA, 50HA/50TA, 20HA/80TA) for their application as materials for wound healing. Surface free energy, as well as their roughness, mechanical properties, water vapor permeability rate, and antioxidant activity were determined. Moreover, their compatibility with blood and osteoblast cells was investigated....

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• Anticancer Properties of Amino Acid and Peptide Derivatives of Mycophenolic Acid

  Publication

  • A. Siebert
  • M. Deptuła
  • M. Cichorek
  • A. Ronowska
  • G. Cholewiński
  • J. Rachoń

  - Anti-Cancer Agents in Medicinal Chemistry - Year 2021

  Background: Although Mycophenolic Acid (MPA) is applied as prodrugs in clinic as an immunosuppressant, it also possesses anticancer activity. MPA acts as Inosine-5’-Monophosphate Dehydrogenase (IMPDH) inhibitor, where the carboxylic group at the end of the side chain interacts with Ser 276 of the enzyme via hydrogen bonds. Therefore, MPA derivatives with other polar groups indicated high inhibition too. On the other hand, potent...

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• ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT

  Journals

  ISSN: 1087-2906