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Search results for: pora dnia a wypadek drogowy
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Wpływ dodatku kwasu deoksyrybonukleinowego (DNA) na właściwości mechaniczne żeli żelatynowych
PublicationKwasy nukleinowe cieszą się coraz większym zainteresowaniem pod względem zastosowania ich w przemyśle farmaceutycznym, kosmetycznym oraz żywnościowym. Określono wpływ dodatku długo- i krótkołańcuchowych kwasów nukleinowych na właściwości mechaniczne żeli żelatynowych. Badania wykazały występowanie specyficznych interakcji pomiędzy żelatyną a kwasami nukleinowymi oraz pozwoliły na ocenę wpływu tych oddziaływań na twardość, kohezyjność,...
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Comparative Analysis of CpG Sites and Islands Distributed in Mitochondrial DNA of Model Organisms
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A Colorimetric Microplate Assay for DNA-Binding Activity of His-Tagged MutS Protein
PublicationA simple microplate method was designed for rapid testing DNA-binding activity of proteins. The principle of the assay involves binding of tested DNA by his-tagged protein immobilized on a nickel-coated ELISA plate, following colorimetric detection of biotinylated DNA with avidin conjugated to horseradish peroxidase. The method was used to compare DNA mismatch binding activities of MutS proteins from three bacterial species. The...
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Methods for Elucidation of DNA-Anticancer Drug Interactions and Their Applications in the Development of New Drugs
PublicationDNA damaging agents including anthracyclines, camptothecins and platinum drugs are among most frequently used drugs in the chemotherapeutic routine. Due to their relatively low selectivity for cancer cells, administration is associated with adverse side effects, whereas the inherent genotoxicity of these drugs is associated with risk of developing secondary cancers. Development of new drugs, which could be spared of these drawbacks...
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The influence of the substrate temperature on the preparation of DNA films for studies under vacuum conditions
PublicationExperiments were carried out to determine the dependence of the physical form of supercoiled DNA films on the initial temperature of the substrate. Such films are often used in irradiation experiments involving low energy particles, like electrons or photons. In order to obtain absolute values for cross sections for such experiments, the spatial distribution of the sample in the film has to be well estimated. These investigations...
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Mechanisms of Damage to DNA Labeled with Electrophilic Nucleobases Induced by Ionizing or UV Radiation
PublicationHypoxia—a hallmark of solid tumors—makes hypoxic cells radioresistant. On the other hand, DNA, the main target of anticancer therapy, is not sensitive to the near UV photons and hydrated electrons, one of the major products of water radiolysis under hypoxic conditions. A possible way to overcome these obstacles to the efficient radio- and photodynamic therapy of cancer is to sensitize the cellular DNA to electrons and/or ultraviolet...
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Ancient mitochondrial DNA and the genetic history of Eurasian beaver (Castor fiber) in Europe
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Photostability pf Cy3 and Cy5-labeled DNA in the presence of metallic silver particles
PublicationZbadano wpływ cząstek metalicznego srebra na fotostabilność oligomerów DNA kowalencyjnie związanych z Cy3 lub Cy5. Zbliżenie fluoroforów do cząstek srebra powodowało zwiększenie intensywności fluorescencji i pojawienie się frakcji emisji bardziej odpornej na wybielanie.
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Confirmative electric DNA array-based test for food poisoning Bacillus cereus
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Theoretical Study of Damage to DNA by 0.2−1.5 eV Electrons Attached to Cytosine
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Single-stranded DNA-binding proteins (SSBs) - sources and applicationsin molecular biology
PublicationBiałka wiążące się do jednoniciowego DNA (SSB) odgrywają ważną rolę w replikacji, rekombinacji i naprawie DNA u bakterii, archea i eukariota. Ostatnio wzrosło zainteresowanie białkami SSB jako przydatnymi narzędziami w metodach badawczych biologii molekularnej, analitycznych i diagnostycznych. Większość znanych prokariotycznych białek SSB zbudowanych jest z czterech podjednostek (homotetramer) z jedną domeną wiążąca (OB) jednoniciowe...
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Isolation and structure of a covalent cross-link adduct between mitomycin C and DNA
PublicationA DNA cross-link adduct of the antitumor agent mitomycin C (MC) to DNA has been isolated and characterized; the results provide direct proof for bifunctional alkylation of DNA by MC. Exposure of MC to Micrococcus luteus DNA under reductive conditions and subsequent nuclease digestion yielded adducts formed between MC and deoxyguanosine residues. In addition to the two known monoadducts, a bisadduct was obtained. Reductive MC activation...
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Decisional-DNA-Based Digital Twin Implementation Architecture for Virtual Engineering Objects
PublicationDigital twin (DT) is an enabling technology that integrates cyber and physical spaces. It is well-fitted for manufacturing setup since it can support digitalized assets and data analytics for product and process control. Conventional manufacturing setups are still widely used all around the world for the fabrication of large-scale production. This article proposes a general DT implementation architecture for engineering objects/artifacts...
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Genome-Wide DNA Methylation and Gene Expression in Patients with Indolent Systemic Mastocytosis
PublicationMastocytosis is a clinically heterogenous, usually acquired disease of the mast cells with a survival time that depends on the time of onset. It ranges from skin-limited to systemic disease, including indolent and more aggressive variants. The presence of the oncogenic KIT p. D816V gene somatic mutation is a crucial element in the pathogenesis. However, further epigenetic regulation may also affect the expression of genes that...
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DNAffinity: a machine-learning approach to predict DNA binding affinities of transcription factors
PublicationWe present a physics-based machine learning approach to predict in vitro transcription factor binding affinities from structural and mechanical DNA properties directly derived from atomistic molecular dynamics simulations. The method is able to predict affinities obtained with techniques as different as uPBM, gcPBM and HT-SELEX with an excellent performance, much better than existing algorithms. Due to its nature, the method can...
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How acidic amino acid residues facilitate DNA target site selection
PublicationDespite the negative charge of the DNA backbone, acidic residues (Asp/Glu) commonly participate in the base readout, with a strong preference for cytosine. In fact, in the solved DNA/protein structures, cytosine is recognized almost exclusively by Asp/Glu through a direct hydrogen bond, while at the same time, adenine, regardless of its amino group, shows no propensity for Asp/Glu. Here, we analyzed the contribution of Asp/Glu...
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Prediction based on integration of Decisional DNA and a feature selection algorithm Relief-F
PublicationThe paper presents prediction model based on Decisional DNA and Set of experienced integrated with Relief_F algorithm for feature selection
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Analysis of magnetic field of Helmholtz's coils
PublicationThe 3-axis fluxgate magnetometer requires conducting a precise calibration in the magnetic field whose value is determined and which is characterized by the high uniformity of the distribution of the field, especially along the axis of the sensors. The generation of the magnetostatic field characterized by the high uniformity, can be achieved by using the Helmholtz's coils. The requirements of the uniformity of distribution of...
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Analysis of magnetic field of Hemholtz's coils and ferromagnetic objects
PublicationThe 3-axis fluxgate magnetometer requires conducting a precise calibration in the magnetic field whose value is determined and which is characterized by the high uniformity of the distribution of the field, especially along the axis of the sensors. The generation of the magnetostatic field characterized by the high uniformity, can be achieved by using the Helmholtz's coils. The requirements of the uniformity of distribution of...
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Nonlinear control of induction motor in field weakning region with consideration of stator flux
PublicationMetody nieliniowgo sterowania mogą poprawić właściwości silnika indukcyjnego w stanach przejściowych wektora strumienia. Badano sterowanie oparte na modelu multiskalarnym silnika indukcyjnego w zakresie osłabiania pola. Dwie nowe zmienne wejściowe pojawiające się w modelu multiskalarnym są równe czynnej i biernej mocy silnika. Pokazano, że te wielkości mogą byc kompensowane, jeżeli rozważane są jako mierzone zakłócenia. Maksymalny...
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Zeszyty Naukowe Wyższej Szkoły Społeczno-Przyrodniczej im. Wincentego Pola w Lublinie
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Arteterapia-Papeles de Arteterapia y Educacion Artistica para la Inclusion Social
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Revista Internacional de Metodos Numericos para Calculo y Diseno en Ingenieria
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Opinia techniczna torów kolejowych Nr 401, 407A i 413 na bocznicy kolejowej Stoczni Gdańskiej S.A. Nawierzchnia kolejowa z szyn S49 (49E1) na płycie żelbetowej z nawierzchnią drogową
PublicationOpinia techniczna torów kolejowych Nr 401, 407A i 413 na bocznicy kolejowej Stoczni Gdańskiej S.A. Nawierzchnia kolejowa z szyn S49 (49E1) na płycie żelbetowej z nawierzchnią drogową
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Reaction of 4-benzylidene-2-methyl-5-oxazolone with amines, Part 2: Influence of substituents in para-position in the phenyl ring and a substituent on amine nitrogen atom on the reaction kinetics
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Systemy przewodów rurowych z tworzyw sztucznych. Systemy poza konstrukcjami budynków do przesyłania wody lub ścieków. Praktyka instalowania nad ziemią i pod ziemią
PublicationZagadnienia prowadzenia rurociągów poza budynkami - posadowienia w gruncie względnie poza gruntem. Szczególne konsekwencje zróżnicowanych warunków posadowienia. Projekt prenormy europejskiej w wersji polskiej. Konsekwencje usterek na poziomie tłumaczenia, różnice w definiowaniu podstawowych zachowań
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Data regarding a new, vector-enzymatic DNA fragment amplification-expression technology for the construction of artificial, concatemeric DNA, RNA and proteins, as well as biological effects of selected polypeptides obtained using this method
PublicationApplications of bioactive peptides and polypeptides are emerging in areas such as drug development and drug delivery systems. These compounds are bioactive, biocompatible and represent a wide range of chemical properties, enabling further adjustments of obtained biomaterials. However, delivering large quantities of peptide derivatives is still challenging. Several methods have been developed for the production of concatemers –...
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Quantum chemical modeling of electrochromism of tungsten oxide films
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Quantum chemical modelling of the process of lithium insertion into WO3 films
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Glosa do uchwały SN z dnia 20 września 2018 r., sygn. I KZP 7/182 (Kumulatywna kwalifikacja prawna a przedawnienie karalności w prawie karnym)
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Polyp of stomach and duodenum - Female, 24 - Tissue image [7110729594544271]
Open Research DataThis is the histopathological image of STOMACH tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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Zachodnioafrykańska Unia Ekonomiczna i Monetarna jako przykład integracji gospodarczej i finansowej w Afryce Zachodniej
PublicationW tekście został przedstawiony jeden z kluczowych elementów procesu integracji gospodarczej zachodniej części kontynentu afrykańskiego, tj. Zachodnioafrykańska Unia Ekonomiczna i Monetarna (franc. Union économique et monétaire ouest-africaine, w skrócie UEMOA). Omówione zostały cele tego ugrupowania w obszarze integracji walutowej oraz ekonomicznej, a także najważniejsze instytucje. Zaprezentowane zostały dotychczasowe osiągnięcia...
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(Vapour + liquid) equilibrium in (n,n-dimethylacetamide + ethanol + water) at the temperature 313.15 K
PublicationW pracy prezentowane są pomiary całkowitej prężności pary dla tytułowego układu trójskładnikowego oraz dla składowych układów binarnych. Uzyskane w pracy wyniki porównane zostały z wcześniejszymi danymi dla podobnych układów. Znaleziono w przybliżeniu liniową zależność pomiędzy wartościami nadmiarowej entalpii swobodnej Gibbsa a objętością molową amidu, spełnianą w układach dwuskładnikowych: amid + alkohol alifatyczny.
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PROJEKTOWANIE NAWIERZCHNI2022-23
e-Learning CoursesKurs przewidziany dla studentów VII semestru studiów inżynierskich kierunku budownictwo specjalności drogowej. Podczas kursu omawiane są podstawowe metody projektowania konstrukcji nawierzchni drogowych, lotniskowych i portowych w technologii asfaltowej, betonu cementowego oraz kostek brukowych. Kurs obejmuje również wstęp i zarys zaawansowanego projektowania mechanistyczno-empirycznego.
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PROJEKTOWANIE NAWIERZCHNI2023-24
e-Learning CoursesKurs przewidziany dla studentów VII semestru studiów inżynierskich kierunku budownictwo specjalności drogowej. Podczas kursu omawiane są podstawowe metody projektowania konstrukcji nawierzchni drogowych, lotniskowych i portowych w technologii asfaltowej, betonu cementowego oraz kostek brukowych. Kurs obejmuje również wstęp i zarys zaawansowanego projektowania mechanistyczno-empirycznego.
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Ageing-Time Dependent Changes of Angiotensin I-Converting Enzyme-Inhibiting Activity of Protein Hydrolysates Obtained from Dry-Cured Pork Loins Inoculated with Probiotic Lactic Acid Bacteria
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LYMPH NODES, Para-aortic lymph node - Female, 62 - Tissue image [3220630024671391]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Para-aortic lymph node - Female, 62 - Tissue image [3220630024676511]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Para-aortic lymph node - Female, 62 - Tissue image [322063002467521]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Para-aortic lymph node - Female, 62 - Tissue image [3220630024673531]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Para-aortic lymph node - Female, 62 - Tissue image [3220630024675741]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Para-aortic lymph node - Female, 62 - Tissue image [3220630024673501]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Para-aortic lymph node - Female, 62 - Tissue image [322063002467321]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Para-aortic lymph node - Female, 62 - Tissue image [3220630024678601]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Para-aortic lymph node - Female, 62 - Tissue image [3220630024676361]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Para-aortic lymph node - Female, 62 - Tissue image [3220630024673551]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Para-aortic lymph node - Female, 62 - Tissue image [3220630024679081]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Para-aortic lymph node - Female, 62 - Tissue image [3220630024671071]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Para-aortic lymph node - Female, 62 - Tissue image [322063002467181]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.
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LYMPH NODES, Para-aortic lymph node - Female, 62 - Tissue image [3220630024679761]
Open Research DataThis is the histopathological image of LYMPH NODES tissue sample obtained in Medical University Gdańsk and deposited in ZMDL-GUMED. The sample image was taken using: Pannoramic 250 3DHistech slide scanner (20x magnification) and saved to DICOM format.