Search results for: ASPARTIC PROTEASE
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Inhibiting Activity of HIV-1: Protease, Reverse Transcriptase and Integrase All Together by Novel Compounds Using Computational Approaches
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The LD loop as an important structural element required for transmission of the allosteric signal in the HtrA (DegP) protease from Escherichia coli
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Regulation of the First Committed Step in Lipopolysaccharide Biosynthesis Catalyzed by LpxC Requires the Essential Protein LapC (YejM) and HslVU Protease
PublicationWe previously showed that lipopolysaccharide (LPS) assembly requires the essential LapB protein to regulate FtsH-mediated proteolysis of LpxC protein that catalyzes the first committed step in the LPS synthesis. To further understand the essential function of LapB and its role in LpxC turnover, multicopy suppressors of ΔlapB revealed that overproduction of HslV protease subunit prevents its lethality by proteolytic degradation...
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Bladder cancer detection using a peptide substrate of the 20S proteasome
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An update on medium- and low-abundant blood plasma proteome of horse
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Screening of potential inhibitors for COVID-19 main protease from phytoconstituents of Tectona grandis Linn: application of molecular modeling studies
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Development of potent and effective SARS-CoV-2 main protease inhibitors based on maleimide analogs for the potential treatment of COVID-19
PublicationIn the present work, we report a new series of potent SARS-CoV-2 Main Protease (Mpro) inhibitors based on maleimide derivatives. The inhibitory activities were tested in an enzymatic assay using recombinant Mpro (3CL Protease from coronavirus SARS-CoV-2). Within the set of new Mpro inhibitors, 6e demonstrated the highest activity in the enzymatic assay with an IC50 value of 8.52 ± 0.44 mM. The IC50 value for Nirmatrelvir (PF-07321332,...
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Substrate profiling of Finegoldia magna SufA protease, inhibitor screening and application to prevent human fibrinogen degradation and bacteria growth in vitro
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Effect of chronic mild stress and imipramine on the proteome of the rat dentate gyrus
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Human proteinase 3 resistance to inhibition extends to alpha‐2 macroglobulin
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Design of selective substrates of proteinase 3 using combinatorial chemistry methods
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Proteome changes upon in ovo stimulation with Lactobacillus synbiotic in chicken liver
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Inhibiting activity of HIV-1: protease, reverse transcriptase and integrase all together by novel compounds using computational approaches (flexible and rigid docking)
PublicationAcquired immunodeficiency syndrome (AIDS), caused by human immunodeficiency virus type 1 (HIV-1) infection, is one of the most challenging diseases in recent decades. Nevertheless the shortcomings of chemical drugs such as toxicity, lack of curative effects, the search for more potent anti-HIV agents have been focused in our study. In current study, novel scaffold was designed having a benzyl and imidazole in it which are very...
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A. Computational analysis by molecular docking of thirty alkaloid compounds from medicinal plants as potent inhibitors of SARS-CoV-2 main protease(2020).
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Different Patterns of mRNA Nuclear Retention during Meiotic Prophase in Larch Microsporocytes
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Lupine embryo axes under salinity stress. II. Mitochondrial proteome response
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A Peptidomimetic Fluorescent Probe to Detect the Trypsin β2 Subunit of the Human 20S Proteasome
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Novel internally quenched substrate of the trypsin-like subunit of 20S eukaryotic proteasome
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Inhibition of Human and Yeast 20S Proteasome by Analogues of Trypsin Inhibitor SFTI-1
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The new fluorogenic substrates of neutrophil proteinase 3 optimized in prime site region
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A new proteinase 3 substrate with improved selectivity over human neutrophil elastase
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Urinary Proteome of Newborn Calves—New Potential in Non-Invasive Neonatal Diagnostic
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Changes in enzymatic activity of fish and slaughter animals meat after high pressure treatment at subzero temperatures
PublicationThe aim of this study was to determine changes in the activity of proteolytic enzymes and transglutaminase of fish and mammal meat after pressurization at subzero temperatures. The activity was measured at the optimal pHs determined for enzymes from particular types of tested meat. It was found that increasing the pressure in the range of 60–193 MPa, did not change significantly the activity of acidic proteases of cod flesh, while...
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Molecular modeling study of tectoquinone and acteoside from Tectona grandis linn: a new SARS-CoV-2 main protease inhibitor against COVID-19
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Synthesis of Novel Phosphonic‐Type Activity‐Based Probes for Neutrophil Serine Proteases and Their Application in Spleen Lysates of Different Organisms
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Identification of serum proteome signatures of locally advanced and metastatic gastric cancer: a pilot study
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Nuclear retention of pre-mRNA involving Cajal bodies during meiotic prophase in plants
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An Insight into the Proteome of Uveal Melanoma-Derived Ectosomes Reveals the Presence of Potentially Useful Biomarkers
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Changes in the Cell Wall Proteome of Leaves in Response to High Temperature Stress in Brachypodium distachyon
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The effects of p53 gene inactivation on mutant proteome expression in a human melanoma cell model
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Modification of ileal proteome in growing pigs by dietary supplementation with inulin or dried chicory root
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Dietary Inclusion of Dried Chicory Root Affects Cecal Mucosa Proteome of Nursery Pigs
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Lactose-rich milk replacer modifies the proteome of bloodplasma in 2-week-old calves
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EP-1817: Radiotherapy-related changes in serum proteome patterns of head and neck cancer patients
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Stress-related expression of the chloroplast EGY3 pseudoprotease and its possible impact on chloroplasts’ proteome composition
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Proteome Analysis of PC12 Cells Reveals Alterations in Translation Regulation and Actin Signaling Induced by Clozapine
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Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis
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Effect of Attractants and Micronutrient Biofortification on the Yield and Quality of Red Clover (Trifolium pratense L.) Seeds
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Asiatic-IIUM Journal of English Language and Literature
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Journal of the Malaysian Branch of the Royal Asiatic Society
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Molecular docking studies towards development of novel Gly-Phe analogs for potential inhibition of Cathepsin C (dipeptidyl peptidase I).
PublicationCathepsin C is a cysteine protease required for activation of various pro-inflammatory serine proteases and, essentially, is of interest as a therapeutic target. Cathepsin C coordinate system was employed as a model to study the interaction of some already available inhibitors of Cathepsin C. Compounds containing Gly-Phe fragment with functional groups at its ends were designed by knowledge based approach. Using AutoDock and...
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Ionizing radiation affects the composition of the proteome of extracellular vesicles released by head-and-neck cancer cells in vitro
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Therapy-Related Changes in the Serum Proteome Patterns of Early Stage Breast Cancer Patients with Different Outcomes
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Potential clinical application of serum proteome mass spectrometry analyses in breast cancer patients diagnosis and management
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Mass spectrometry-based serum proteome pattern analysis in molecular diagnostics of early stage breast cancer
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Perturbations of the hepatic proteome behind the onset of metabolic disorders in mouse offspring developed following embryo manipulation
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Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models
PublicationThe proteasome has key roles in neuronal proteostasis, including the removal of misfolded and oxidized proteins, presynaptic protein turnover, and synaptic efficacy and plasticity. Proteasome dysfunction is a prominent feature of Alzheimer’s disease (AD). We show that prevention of proteasome dysfunction by genetic manipulation delays mortality, cell death, and cognitive deficits in fly and cell culture AD models. We developed...
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Inhibitors and Antibody Fragments as Potential Anti-Inflammatory Therapeutics Targeting Neutrophil Proteinase 3 in Human Disease
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Design of serine proteinase inhibitors by combinatorial chemistry using trypsin inhibitor SFTI‐1 as a starting structure
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Hepatic proteome changes induced by dietary supplementation with two levels of native chicory inulin in young pigs
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